DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pepck2 and PCK1

DIOPT Version :9

Sequence 1:	NP_611341.1	Gene:	Pepck2 / 37130	FlyBaseID:	FBgn0034356	Length:	638	Species:	Drosophila melanogaster
Sequence 2:	NP_002582.3	Gene:	PCK1 / 5105	HGNCID:	8724	Length:	622	Species:	Homo sapiens

Alignment Length:	632	Identity:	398/632 - (62%)
Similarity:	482/632 - (76%)	Gaps:	21/632 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 PHRNSNFRLTCRFLSIQYGDAKILTPAVKQYVEKCVELCQPERVHICDGTEVESKLLQGIMLKKG 80
            |...:...|:.:   :..|....|..||::::|...|||||:.:|||||:|.|:..|.|.|.::|
Human     3 PQLQNGLNLSAK---VVQGSLDSLPQAVREFLENNAELCQPDHIHICDGSEEENGRLLGQMEEEG 64

  Fly    81 TIIPLPKYENCWLARTNPADVARVEGKTFISTDSKEQTVPVTEKATPGMLGNWIAEKDMQAAIKE 145
            .:..|.||:|||||.|:|.||||:|.||.|.|..:..|||: .|.....||.|::|:|.:.|...
Human    65 ILRRLKKYDNCWLALTDPRDVARIESKTVIVTQEQRDTVPI-PKTGLSQLGRWMSEEDFEKAFNA 128

  Fly   146 RFPGCMKGRTMYVIPFSMGPVGSPLSKIGIEITDSPYVVESMKIMTRAGNPVLNYLQSGDGQFVK 210
            ||||||||||||||||||||:||||||||||:|||||||.||:||||.|.|||..:  |||:|||
Human   129 RFPGCMKGRTMYVIPFSMGPLGSPLSKIGIELTDSPYVVASMRIMTRMGTPVLEAV--GDGEFVK 191

  Fly   211 CLHSVGTPKSGVQAMP-------SWPCDPERTIVLHKPAENEIVSYGSGYGGNSLLGKKCLALRI 268
            ||||||.|      :|       :|||:||.|::.|.|...||:|:||||||||||||||.|||:
Human   192 CLHSVGCP------LPLQKPLVNNWPCNPELTLIAHLPDRREIISFGSGYGGNSLLGKKCFALRM 250

  Fly   269 GSTIAKREGWLAEHMLILGITNPQGKKIYIAAAFPSACGKTNLAMMTPTLPGYKVECVGDDIAWM 333
            .|.:||.||||||||||||||||:|:|.|:||||||||||||||||.|:|||:||||||||||||
Human   251 ASRLAKEEGWLAEHMLILGITNPEGEKKYLAAAFPSACGKTNLAMMNPSLPGWKVECVGDDIAWM 315

  Fly   334 KFDNKGVLRAINPENGFFGVAPGTSRATNPIAMDTIFRNSVFTNVASTSDGGVYWEGMEKDQLKG 398
            |||.:|.||||||||||||||||||..|||.|:.||.:|::|||||.||||||||||:::....|
Human   316 KFDAQGHLRAINPENGFFGVAPGTSVKTNPNAIKTIQKNTIFTNVAETSDGGVYWEGIDEPLASG 380

  Fly   399 VTVTDWLGKLWSQESGKPAAHPNSRFCTPASQCPIIDPAWEDSEGVPISAILFGGRRPSGVPLVY 463
            ||:|.|..|.||.|.|:|.||||||||||||||||||.|||..|||||..|:||||||:||||||
Human   381 VTITSWKNKEWSSEDGEPCAHPNSRFCTPASQCPIIDAAWESPEGVPIEGIIFGGRRPAGVPLVY 445

  Fly   464 EARDWKHGVFIGAAMRSEATAAAEFKGKVIMHDPFAMRPFFGYNFGDYLGHWLSMEQR--GQVPK 526
            ||..|:||||:|||||||||||||.|||:|||||||||||||||||.||.|||||.|.  .::||
Human   446 EALSWQHGVFVGAAMRSEATAAAEHKGKIIMHDPFAMRPFFGYNFGKYLAHWLSMAQHPAAKLPK 510

  Fly   527 IFHVNWFRKSSEGKFLWPGFGENSRVLDWIFRRVEGEQCFEDSPIGRLPSKNSLNLDSLENIDLD 591
            |||||||||..||||||||||||||||:|:|.|::|:...:.:|||.:|.:::|||..|.:|::.
Human   511 IFHVNWFRKDKEGKFLWPGFGENSRVLEWMFNRIDGKASTKLTPIGYIPKEDALNLKGLGHINMM 575

  Fly   592 QLFDLPKDFWEQEVAAIERYFEEQVGHHLPGAVAEELRELKARVADM 638
            :||.:.|:|||:||..||:|.|:||...||..:..|:..||.|::.|
Human   576 ELFSISKEFWEKEVEDIEKYLEDQVNADLPCEIEREILALKQRISQM 622

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pepck2	NP_611341.1	PEPCK	45..635	CDD:279197	390/598 (65%)
PCK1	NP_002582.3	PEPCK_GTP	27..615	CDD:238417	389/596 (65%)
		Substrate binding. /evidence=ECO:0000269\|PubMed:11851336, ECO:0000269\|PubMed:14552798, ECO:0000269\|PubMed:17532214	235..237		1/1 (100%)
		Substrate binding. /evidence=ECO:0000269\|PubMed:11851336, ECO:0000269\|PubMed:14552798, ECO:0000269\|PubMed:17532214	403..405		1/1 (100%)
		Omega-loop. /evidence=ECO:0000250\|UniProtKB:P07379	457..487		27/29 (93%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159754
Domainoid	1	1.000	544	1.000	Domainoid score	I259
eggNOG	1	0.900	-	-		E1_COG1274
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1944
Inparanoid	1	1.050	841	1.000	Inparanoid score	I448
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61114
OrthoDB	1	1.010	-	-		D135245at33208
OrthoFinder	1	1.000	-	-		FOG0002991
OrthoInspector	1	1.000	-	-		mtm8610
orthoMCL	1	0.900	-	-		OOG6_102518
Panther	1	1.100	-	-	O	PTHR11561
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1986
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.770