DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pepck2 and pck2

DIOPT Version :9

Sequence 1:	NP_611341.1	Gene:	Pepck2 / 37130	FlyBaseID:	FBgn0034356	Length:	638	Species:	Drosophila melanogaster
Sequence 2:	NP_998357.1	Gene:	pck2 / 406473	ZFINID:	ZDB-GENE-040426-2266	Length:	636	Species:	Danio rerio

Alignment Length:	615	Identity:	383/615 - (62%)
Similarity:	453/615 - (73%)	Gaps:	25/615 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 LTPAVKQYVEKCVELCQPERVHICDGTEVESKLLQGIMLKKGTIIPLPKYENCWLARTNPADVAR 103
            |.|:|.::|......|:|.:||:..||..|:..|...:.|:|.:..|.||||||||||:|.||||
Zfish    31 LPPSVAEFVSGAAAECKPAKVHVVTGTPEETADLLANLEKEGMVKKLAKYENCWLARTDPKDVAR 95

  Fly   104 VEGKTFISTDSKEQTVPVTEKATPGMLGNWIAEKDMQAAIKERFPGCMKGRTMYVIPFSMGPVGS 168
            ||.||.|.|.::..|:|:........||:|::|:|.|.|.::||||||.||||||||||||||.|
Zfish    96 VESKTVIVTKNQRDTIPIPSGGAKSQLGSWMSEQDFQKAREDRFPGCMAGRTMYVIPFSMGPVNS 160

  Fly   169 PLSKIGIEITDSPYVVESMKIMTRAGNPVLNYLQSGDGQFVKCLHSVGTPKSGVQAMP------- 226
            .|:|.|:::|||||||.||.||||.|.||:..|..| .:||:|.||||.|      :|
Zfish   161 SLAKFGVQVTDSPYVVASMGIMTRMGTPVMEKLAQG-AEFVRCQHSVGRP------LPLKGPLVN 218

  Fly   227 SWPCDPERTIVLHKPAENEIVSYGSGYGGNSLLGKKCLALRIGSTIAKREGWLAEHMLILGITNP 291
            ||||:||:.::.|.|...:|:|:||||||||||||||.||||.|.|||.||||||||||||||||
Zfish   219 SWPCNPEKVLISHLPDTRQILSFGSGYGGNSLLGKKCFALRIASRIAKDEGWLAEHMLILGITNP 283

  Fly   292 QGKKIYIAAAFPSACGKTNLAMMTPTLPGYKVECVGDDIAWMKFDNKGVLRAINPENGFFGVAPG 356
            ||.|.||||||||||||||||||.|:|||:|||||||||||||||::|.||||||||||||||||
Zfish   284 QGVKRYIAAAFPSACGKTNLAMMKPSLPGWKVECVGDDIAWMKFDSQGKLRAINPENGFFGVAPG 348

  Fly   357 TSRATNPIAMDTIFRNSVFTNVASTSDGGVYWEGMEKDQLKGVTVTDWLGKLWSQESGKPAAHPN 421
            ||..|||.||:||.||:|||||..||||||:|||:| ....|:.:|||.||.|........||||
Zfish   349 TSLKTNPHAMETISRNTVFTNVGETSDGGVWWEGLE-PPAPGIKLTDWHGKSWKYGDSTLCAHPN 412

  Fly   422 SRFCTPASQCPIIDPAWEDSEGVPISAILFGGRRPSGVPLVYEARDWKHGVFIGAAMRSEATAAA 486
            ||||.||.|||||||.||..|||||.||:||||||.|||||||:.:|:||||:|||||||:||||
Zfish   413 SRFCAPAGQCPIIDPLWESDEGVPIDAIVFGGRRPEGVPLVYESFNWRHGVFVGAAMRSESTAAA 477

  Fly   487 EFKGKVIMHDPFAMRPFFGYNFGDYLGHWLSMEQR---GQVPKIFHVNWFRKSSE-GKFLWPGFG 547
            |.||||||||||||||||||||||||.||||||.|   .|:|||||||||||..: |.|||||||
Zfish   478 EHKGKVIMHDPFAMRPFFGYNFGDYLSHWLSMETRKGPTQLPKIFHVNWFRKDQKTGSFLWPGFG 542

  Fly   548 ENSRVLDWIFRRV----EGEQCFEDSPIGRLPSKNSLNLDSL-ENIDLDQLFDLPKDFWEQEVAA 607
            ||:|||:|||:|.    |.|...: |.:|.:|...::|.:.| .|||:..||||||.||::|...
Zfish   543 ENARVLEWIFKRCGRTSENEAATK-SIVGWIPQNGAINTEGLGGNIDMGALFDLPKPFWQKETQE 606

  Fly   608 IERYFEEQVGHHLPGAVAEELRELKARVAD 637
            :..||.:|||..||..|..||:.|:.||.|
Zfish   607 LRTYFNQQVGADLPAQVEGELKALEERVRD 636

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pepck2	NP_611341.1	PEPCK	45..635	CDD:279197	377/605 (62%)
pck2	NP_998357.1	PEPCK	37..634	CDD:279197	377/605 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595987
Domainoid	1	1.000	294	1.000	Domainoid score	I1470
eggNOG	1	0.900	-	-		E1_COG1274
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	831	1.000	Inparanoid score	I438
OMA	1	1.010	-	-		QHG61114
OrthoDB	1	1.010	-	-		D135245at33208
OrthoFinder	1	1.000	-	-		FOG0002991
OrthoInspector	1	1.000	-	-		mtm6511
orthoMCL	1	0.900	-	-		OOG6_102518
Panther	1	1.100	-	-	O	PTHR11561
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4022
SonicParanoid	1	1.000	-	-		X1986
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.800