DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pepck2 and pck1

DIOPT Version :9

Sequence 1:	NP_611341.1	Gene:	Pepck2 / 37130	FlyBaseID:	FBgn0034356	Length:	638	Species:	Drosophila melanogaster
Sequence 2:	NP_999916.1	Gene:	pck1 / 378727	ZFINID:	ZDB-GENE-030909-11	Length:	630	Species:	Danio rerio

Alignment Length:	629	Identity:	385/629 - (61%)
Similarity:	467/629 - (74%)	Gaps:	20/629 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 PHRNSNFRLTCRFLSIQYGDAKILTPAVKQYVEKCVELCQPERVHICDGTEVESKLLQGIMLKKG 80
            |...|..|...|.|.   ||...|:.:|:::::..|.||||:.:|||||:|.|:..:..::.::|
Zfish     3 PQLQSQDRSCPRVLQ---GDLASLSASVREFIDSSVSLCQPDALHICDGSEQENSTILSLLEEQG 64

  Fly    81 TIIPLPKYENCWLARTNPADVARVEGKTFISTDSKEQTVPVTEKATPGMLGNWIAEKDMQAAIKE 145
            .|..|.||.|||||||:|.||||||.||.|.|..:..|||.........||.|:..::...|:..
Zfish    65 AIKRLRKYSNCWLARTDPRDVARVESKTVIVTAEQRDTVPTPTGGGVSQLGRWMCPEEWDKAMNL 129

  Fly   146 RFPGCMKGRTMYVIPFSMGPVGSPLSKIGIEITDSPYVVESMKIMTRAGNPVLNYLQSGDGQFVK 210
            |||||||||.|||||||||||||||||||:|:|||||||.||:||||.|..||:.|  |:|:||:
Zfish   130 RFPGCMKGRVMYVIPFSMGPVGSPLSKIGVELTDSPYVVASMRIMTRMGKTVLSAL--GNGEFVR 192

  Fly   211 CLHSVGTPKSGVQAMP-------SWPCDPERTIVLHKPAENEIVSYGSGYGGNSLLGKKCLALRI 268
            ||||||.|      :|       :|||:||.|:|.|.|.:.:|||:||||||||||||||.||||
Zfish   193 CLHSVGCP------LPLKKPLVNNWPCNPELTLVAHIPDQRKIVSFGSGYGGNSLLGKKCFALRI 251

  Fly   269 GSTIAKREGWLAEHMLILGITNPQGKKIYIAAAFPSACGKTNLAMMTPTLPGYKVECVGDDIAWM 333
            .|.|||.||||||||||||||||.|:|.|.|||||||||||||||:.|:|||:||||||||||||
Zfish   252 ASRIAKEEGWLAEHMLILGITNPAGQKKYFAAAFPSACGKTNLAMLKPSLPGWKVECVGDDIAWM 316

  Fly   334 KFDNKGVLRAINPENGFFGVAPGTSRATNPIAMDTIFRNSVFTNVASTSDGGVYWEGMEKDQLKG 398
            |||.:|.||||||||||||||||||..|||.||.||..|::|||||.:|||||:||||::|..:|
Zfish   317 KFDKEGNLRAINPENGFFGVAPGTSSKTNPNAMSTISCNTLFTNVAESSDGGVFWEGMDEDLPEG 381

  Fly   399 VTVTDWLGKLWSQESGKPAAHPNSRFCTPASQCPIIDPAWEDSEGVPISAILFGGRRPSGVPLVY 463
            ||:|.|..:.|:.|.|:|.|||||||||||:|||||||.||..|||||.||:||||||.||||||
Zfish   382 VTLTSWKNQPWTPEDGEPCAHPNSRFCTPAAQCPIIDPQWESPEGVPIEAIIFGGRRPQGVPLVY 446

  Fly   464 EARDWKHGVFIGAAMRSEATAAAEFKGKVIMHDPFAMRPFFGYNFGDYLGHWLSMEQR--GQVPK 526
            ||.||.||||:||:||||||||||.|||||||||||||||||||||.||.||||||||  .::||
Zfish   447 EAFDWAHGVFVGASMRSEATAAAEHKGKVIMHDPFAMRPFFGYNFGQYLSHWLSMEQRPGAKLPK 511

  Fly   527 IFHVNWFRKSSEGKFLWPGFGENSRVLDWIFRRVEGEQCFEDSPIGRLPSKNSLNLDSLENIDLD 591
            |||||||.:||.|:|||||||||.|||:|:|.|:.|......:.:|.:|:..:|||..|.:::..
Zfish   512 IFHVNWFGRSSSGRFLWPGFGENIRVLEWMFGRLSGGAEARTTAVGLVPADGALNLHGLPDVEPL 576

  Fly   592 QLFDLPKDFWEQEVAAIERYFEEQVGHHLPGAVAEELRELKARV 635
            :||.:.::||.||:..|..||..::...||..:..:|..|:.|:
Zfish   577 ELFRVSQEFWMQELQEIREYFSRELNRDLPQEMQRQLELLEHRL 620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pepck2	NP_611341.1	PEPCK	45..635	CDD:279197	375/598 (63%)
pck1	NP_999916.1	PEPCK_GTP	27..616	CDD:238417	375/596 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595985
Domainoid	1	1.000	527	1.000	Domainoid score	I275
eggNOG	1	0.900	-	-		E1_COG1274
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1944
Inparanoid	1	1.050	831	1.000	Inparanoid score	I438
OMA	1	1.010	-	-		QHG61114
OrthoDB	1	1.010	-	-		D135245at33208
OrthoFinder	1	1.000	-	-		FOG0002991
OrthoInspector	1	1.000	-	-		mtm6511
orthoMCL	1	0.900	-	-		OOG6_102518
Panther	1	1.100	-	-	O	PTHR11561
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1986
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.770