DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pepck2 and Pepck1

DIOPT Version :9

Sequence 1:	NP_611341.1	Gene:	Pepck2 / 37130	FlyBaseID:	FBgn0034356	Length:	638	Species:	Drosophila melanogaster
Sequence 2:	NP_523784.2	Gene:	Pepck1 / 37131	FlyBaseID:	FBgn0003067	Length:	647	Species:	Drosophila melanogaster

Alignment Length:	633	Identity:	443/633 - (69%)
Similarity:	525/633 - (82%)	Gaps:	6/633 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 CGLVSPHR----NSNFRLTCRFLSIQYGDAKILTPAVKQYVEKCVELCQPERVHICDGTEVESKL 71
            |||...|:    |.......|.:.|.||:..:||..|:.:||:.:.||||::||||||:|.|:|:
  Fly    16 CGLPQLHKLRQDNCGLYSHIRGIPISYGNVDLLTTGVRAFVEEGIALCQPDQVHICDGSEQENKV 80

  Fly    72 LQGIMLKKGTIIPLPKYENCWLARTNPADVARVEGKTFISTDSKEQTVPVTEKATPGMLGNWIAE 136
            |...:|:.|||:|||||:||||||||||||||||.:|||.|:.:|:|:|...:...|.|||||:.
  Fly    81 LIKSLLEAGTIVPLPKYDNCWLARTNPADVARVESRTFICTERREETIPTPVEGVKGTLGNWISP 145

  Fly   137 KDMQAAIKERFPGCMKGRTMYVIPFSMGPVGSPLSKIGIEITDSPYVVESMKIMTRAGNPVLNYL 201
            .||.||:::|||||||||||||:|||||||||||||||||:|||.|||.||:||||.|..||..|
  Fly   146 SDMDAAVQQRFPGCMKGRTMYVVPFSMGPVGSPLSKIGIELTDSAYVVASMRIMTRMGAAVLRQL 210

  Fly   202 QSGDGQFVKCLHSVGTPKSGVQAMPSWPCDPERTIVLHKPAENEIVSYGSGYGGNSLLGKKCLAL 266
            ...: :||:.|||||.|.:|....|||||||||||:|||||||.||||||||||||||||||.||
  Fly   211 AKKE-EFVRALHSVGAPANGQVEQPSWPCDPERTIILHKPAENLIVSYGSGYGGNSLLGKKCFAL 274

  Fly   267 RIGSTIAKREGWLAEHMLILGITNPQGKKIYIAAAFPSACGKTNLAMMTPTLPGYKVECVGDDIA 331
            ||||||||:||||||||||||||:|:|:|.||.||||||||||||||:.|:|..|||||||||||
  Fly   275 RIGSTIAKQEGWLAEHMLILGITDPKGEKKYITAAFPSACGKTNLAMLNPSLANYKVECVGDDIA 339

  Fly   332 WMKFDNKGVLRAINPENGFFGVAPGTSRATNPIAMDTIFRNSVFTNVASTSDGGVYWEGMEKDQL 396
            |||||::||||||||||||||||||||..||||||:|:|:|::||||||||||||:|||||....
  Fly   340 WMKFDSQGVLRAINPENGFFGVAPGTSMETNPIAMNTVFKNTIFTNVASTSDGGVFWEGMESSLA 404

  Fly   397 KGVTVTDWLGKLWSQESGKPAAHPNSRFCTPASQCPIIDPAWEDSEGVPISAILFGGRRPSGVPL 461
            ..|.:||||||.|:::||||||||||||||||:||||||.||||..||||||:|||||||:||||
  Fly   405 PNVQITDWLGKPWTKDSGKPAAHPNSRFCTPAAQCPIIDEAWEDPAGVPISAMLFGGRRPAGVPL 469

  Fly   462 VYEARDWKHGVFIGAAMRSEATAAAEFKGKVIMHDPFAMRPFFGYNFGDYLGHWLSMEQRGQVPK 526
            :||||||.||||||||||||||||||.|||||||||||||||||||||||:.||||||:||||||
  Fly   470 IYEARDWTHGVFIGAAMRSEATAAAEHKGKVIMHDPFAMRPFFGYNFGDYVAHWLSMEKRGQVPK 534

  Fly   527 IFHVNWFRKSSEGKFLWPGFGENSRVLDWIFRRVEGEQCFEDSPIGRLPSKNSLNLDSL-ENIDL 590
            ||||||||||:||||:|||:|||||||:||.|||.||.|:.||.||.:|::.:||||.: :.:|:
  Fly   535 IFHVNWFRKSAEGKFMWPGYGENSRVLEWILRRVNGESCYVDSAIGHIPAEGALNLDGMKDKVDV 599

  Fly   591 DQLFDLPKDFWEQEVAAIERYFEEQVGHHLPGAVAEELRELKARVADM 638
            .::|.|||:||.|||..|..|||.|||..||.::.::|.||.:||.::
  Fly   600 KEIFSLPKEFWSQEVKDIRTYFESQVGADLPASIYQQLDELSSRVDNL 647

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pepck2	NP_611341.1	PEPCK	45..635	CDD:279197	429/590 (73%)
Pepck1	NP_523784.2	PEPCK	54..644	CDD:279197	429/590 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45470296
Domainoid	1	1.000	527	1.000	Domainoid score	I275
eggNOG	1	0.900	-	-		E1_COG1274
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	831	1.000	Inparanoid score	I438
Isobase	1	0.950	-	0	Normalized mean entropy	S2278
OMA	1	1.010	-	-		QHG61114
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002991
OrthoInspector	1	1.000	-	-		mtm6511
orthoMCL	1	0.900	-	-		OOG6_102518
Panther	1	1.100	-	-	P	PTHR11561
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1986
	12	11.750