DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pepck2 and Pck1

DIOPT Version :9

Sequence 1:	NP_611341.1	Gene:	Pepck2 / 37130	FlyBaseID:	FBgn0034356	Length:	638	Species:	Drosophila melanogaster
Sequence 2:	NP_942075.1	Gene:	Pck1 / 362282	RGDID:	3267	Length:	622	Species:	Rattus norvegicus

Alignment Length:	614	Identity:	396/614 - (64%)
Similarity:	472/614 - (76%)	Gaps:	18/614 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 GDAKILTPAVKQYVEKCVELCQPERVHICDGTEVESKLLQGIMLKKGTIIPLPKYENCWLARTNP 98
            |....|...|:::||...:|||||.:|||||:|.|...|...|.::|.|..|.||:|||||.|:|
  Rat    18 GSLDSLPQEVRKFVEGNAQLCQPEYIHICDGSEEEYGRLLAHMQEEGVIRKLKKYDNCWLALTDP 82

  Fly    99 ADVARVEGKTFISTDSKEQTVPVTEKATPGMLGNWIAEKDMQAAIKERFPGCMKGRTMYVIPFSM 163
            .||||:|.||.|.|..:..|||: .|:....||.|::|:|.:.|...||||||||||||||||||
  Rat    83 RDVARIESKTVIITQEQRDTVPI-PKSGQSQLGRWMSEEDFEKAFNARFPGCMKGRTMYVIPFSM 146

  Fly   164 GPVGSPLSKIGIEITDSPYVVESMKIMTRAGNPVLNYLQSGDGQFVKCLHSVGTPKSGVQAMP-- 226
            ||:||||:|||||:|||||||.||:||||.|..||..|  |||:|:|||||||.|      :|
  Rat   147 GPLGSPLAKIGIELTDSPYVVASMRIMTRMGTSVLEAL--GDGEFIKCLHSVGCP------LPLK 203

  Fly   227 -----SWPCDPERTIVLHKPAENEIVSYGSGYGGNSLLGKKCLALRIGSTIAKREGWLAEHMLIL 286
                 :|.|:||.|::.|.|...||:|:||||||||||||||.||||.|.:||.|||||||||||
  Rat   204 KPLVNNWACNPELTLIAHLPDRREIISFGSGYGGNSLLGKKCFALRIASRLAKEEGWLAEHMLIL 268

  Fly   287 GITNPQGKKIYIAAAFPSACGKTNLAMMTPTLPGYKVECVGDDIAWMKFDNKGVLRAINPENGFF 351
            |||||:|||.|:||||||||||||||||.|||||:|||||||||||||||.:|.|||||||||||
  Rat   269 GITNPEGKKKYLAAAFPSACGKTNLAMMNPTLPGWKVECVGDDIAWMKFDAQGNLRAINPENGFF 333

  Fly   352 GVAPGTSRATNPIAMDTIFRNSVFTNVASTSDGGVYWEGMEKDQLKGVTVTDWLGKLWSQESGKP 416
            |||||||..|||.|:.||.:|::|||||.||||||||||:::....|||:|.|..|.|..:..:|
  Rat   334 GVAPGTSVKTNPNAIKTIQKNTIFTNVAETSDGGVYWEGIDEPLAPGVTITSWKNKEWRPQDEEP 398

  Fly   417 AAHPNSRFCTPASQCPIIDPAWEDSEGVPISAILFGGRRPSGVPLVYEARDWKHGVFIGAAMRSE 481
            .||||||||||||||||||||||..|||||..|:||||||:||||||||..|:||||:|||||||
  Rat   399 CAHPNSRFCTPASQCPIIDPAWESPEGVPIEGIIFGGRRPAGVPLVYEALSWQHGVFVGAAMRSE 463

  Fly   482 ATAAAEFKGKVIMHDPFAMRPFFGYNFGDYLGHWLSMEQR--GQVPKIFHVNWFRKSSEGKFLWP 544
            ||||||.|||||||||||||||||||||.||.|||||..|  .::|||||||||||...||||||
  Rat   464 ATAAAEHKGKVIMHDPFAMRPFFGYNFGKYLAHWLSMAHRPAAKLPKIFHVNWFRKDKNGKFLWP 528

  Fly   545 GFGENSRVLDWIFRRVEGEQCFEDSPIGRLPSKNSLNLDSLENIDLDQLFDLPKDFWEQEVAAIE 609
            |||||||||:|:|.|:|||...:.:|||.:|.:::|||..|.::::::||.:.|:|||:||..|:
  Rat   529 GFGENSRVLEWMFGRIEGEDSAKLTPIGYVPKEDALNLKGLGDVNVEELFGISKEFWEKEVEEID 593

  Fly   610 RYFEEQVGHHLPGAVAEELRELKARVADM 638
            :|.|:||...||..:..|||.||.|::.|
  Rat   594 KYLEDQVNADLPYEIERELRALKQRISQM 622

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pepck2	NP_611341.1	PEPCK	45..635	CDD:279197	391/598 (65%)
Pck1	NP_942075.1	PEPCK_GTP	27..615	CDD:238417	390/596 (65%)
		Substrate binding. /evidence=ECO:0000269\|PubMed:18197707, ECO:0000269\|PubMed:18772387, ECO:0000269\|PubMed:20476774, ECO:0000269\|PubMed:23127136, ECO:0000269\|PubMed:24863970	235..237		1/1 (100%)
		Substrate binding. /evidence=ECO:0000269\|PubMed:18197707, ECO:0000269\|PubMed:18772387, ECO:0000269\|PubMed:20476774, ECO:0000269\|PubMed:23127136, ECO:0000269\|PubMed:24863970	403..405		1/1 (100%)
		Omega-loop. /evidence=ECO:0000269\|PubMed:28345895	457..487		28/29 (97%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353822
Domainoid	1	1.000	546	1.000	Domainoid score	I250
eggNOG	1	0.900	-	-		E1_COG1274
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1944
Inparanoid	1	1.050	827	1.000	Inparanoid score	I436
OMA	1	1.010	-	-		QHG61114
OrthoDB	1	1.010	-	-		D135245at33208
OrthoFinder	1	1.000	-	-		FOG0002991
OrthoInspector	1	1.000	-	-		otm45437
orthoMCL	1	0.900	-	-		OOG6_102518
Panther	1	1.100	-	-	O	PTHR11561
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1986
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.770