Protein Alignment Pepck2 and Pck1

DIOPT Version :9

• Sequence 1: NP_611341.1
• Gene: Pepck2 / 37130
• FlyBaseID: FBgn0034356
• Length: 638
• Species: Drosophila melanogaster
• Sequence 2: NP_035174.1
• Gene: Pck1 / 18534
• MGIID: 97501
• Length: 622
• Species: Mus musculus
• Alignment Length: 614
• Identity: 397/614 - (64%)
• Similarity: 471/614 - (76%)
• Gaps: 18/614 - (2%)

  Fly    34 GDAKILTPAVKQYVEKCVELCQPERVHICDGTEVESKLLQGIMLKKGTIIPLPKYENCWLARTNP 98
            |....|..||:::||...:|||||.:|||||:|.|...|...|.::|.|..|.||:|||||.|:|
Mouse    18 GSLDSLPQAVRKFVEGNAQLCQPEYIHICDGSEEEYGQLLAHMQEEGVIRKLKKYDNCWLALTDP 82

  Fly    99 ADVARVEGKTFISTDSKEQTVPVTEKATPGMLGNWIAEKDMQAAIKERFPGCMKGRTMYVIPFSM 163
            .||||:|.||.|.|..:..|||: .|.....||.|::|:|.:.|...||||||||||||||||||
Mouse    83 RDVARIESKTVIITQEQRDTVPI-PKTGLSQLGRWMSEEDFEKAFNARFPGCMKGRTMYVIPFSM 146

  Fly   164 GPVGSPLSKIGIEITDSPYVVESMKIMTRAGNPVLNYLQSGDGQFVKCLHSVGTPKSGVQAMP-- 226
            ||:||||:|||||:|||||||.||:||||.|..||..|  |||:|:|||||||.|      :|
Mouse   147 GPLGSPLAKIGIELTDSPYVVASMRIMTRMGISVLEAL--GDGEFIKCLHSVGCP------LPLK 203

  Fly   227 -----SWPCDPERTIVLHKPAENEIVSYGSGYGGNSLLGKKCLALRIGSTIAKREGWLAEHMLIL 286
                 :|.|:||.|::.|.|...||:|:||||||||||||||.||||.|.:||.|||||||||||
Mouse   204 KPLVNNWACNPELTLIAHLPDRREIISFGSGYGGNSLLGKKCFALRIASRLAKEEGWLAEHMLIL 268

  Fly   287 GITNPQGKKIYIAAAFPSACGKTNLAMMTPTLPGYKVECVGDDIAWMKFDNKGVLRAINPENGFF 351
            |||||:|||.|:||||||||||||||||.|:|||:|||||||||||||||.:|.|||||||||||
Mouse   269 GITNPEGKKKYLAAAFPSACGKTNLAMMNPSLPGWKVECVGDDIAWMKFDAQGNLRAINPENGFF 333

  Fly   352 GVAPGTSRATNPIAMDTIFRNSVFTNVASTSDGGVYWEGMEKDQLKGVTVTDWLGKLWSQESGKP 416
            |||||||..|||.|:.||.:|::|||||.||||||||||:::....|||:|.|..|.|..:..:|
Mouse   334 GVAPGTSVKTNPNAIKTIQKNTIFTNVAETSDGGVYWEGIDEPLAPGVTITSWKNKEWRPQDAEP 398

  Fly   417 AAHPNSRFCTPASQCPIIDPAWEDSEGVPISAILFGGRRPSGVPLVYEARDWKHGVFIGAAMRSE 481
            .||||||||||||||||||||||..|||||..|:||||||.||||||||..|:||||:|||||||
Mouse   399 CAHPNSRFCTPASQCPIIDPAWESPEGVPIEGIIFGGRRPEGVPLVYEALSWQHGVFVGAAMRSE 463

  Fly   482 ATAAAEFKGKVIMHDPFAMRPFFGYNFGDYLGHWLSMEQR--GQVPKIFHVNWFRKSSEGKFLWP 544
            ||||||.|||:|||||||||||||||||.||.|||||..|  .::|||||||||||..:||||||
Mouse   464 ATAAAEHKGKIIMHDPFAMRPFFGYNFGKYLAHWLSMAHRPAAKLPKIFHVNWFRKDKDGKFLWP 528

  Fly   545 GFGENSRVLDWIFRRVEGEQCFEDSPIGRLPSKNSLNLDSLENIDLDQLFDLPKDFWEQEVAAIE 609
            |||||||||:|:|.|:|||...:.:|||.:|.:|:|||..|..:::::||.:.|:|||:||..|:
Mouse   529 GFGENSRVLEWMFGRIEGEDSAKLTPIGYIPKENALNLKGLGGVNVEELFGISKEFWEKEVEEID 593

  Fly   610 RYFEEQVGHHLPGAVAEELRELKARVADM 638
            ||.|:||...||..:..|||.||.|::.|
Mouse   594 RYLEDQVNTDLPYEIERELRALKQRISQM 622

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pepck2	NP_611341.1	PEPCK	45..635	CDD:279197	391/598 (65%)
Pck1	NP_035174.1	PEPCK_GTP	27..615	CDD:238417	390/596 (65%)
		Substrate binding. /evidence=ECO:0000250|UniProtKB:P07379	235..237		1/1 (100%)
		Substrate binding. /evidence=ECO:0000250|UniProtKB:P07379	403..405		1/1 (100%)
		Omega-loop. /evidence=ECO:0000250|UniProtKB:P07379	457..487		27/29 (93%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850125
Domainoid	1	1.000	549	1.000	Domainoid score	I256
eggNOG	1	0.900	-	-		E1_COG1274
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1944
Inparanoid	1	1.050	839	1.000	Inparanoid score	I445
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61114
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002991
OrthoInspector	1	1.000	-	-		mtm8845
orthoMCL	1	0.900	-	-		OOG6_102518
Panther	1	1.100	-	-	O	PTHR11561
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1986
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.760