DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43066 and Slc6a2

DIOPT Version :9

Sequence 1:	NP_001246408.1	Gene:	CG43066 / 37129	FlyBaseID:	FBgn0262476	Length:	721	Species:	Drosophila melanogaster
Sequence 2:	NP_112633.2	Gene:	Slc6a2 / 83511	RGDID:	621822	Length:	617	Species:	Rattus norvegicus

Alignment Length:	617	Identity:	222/617 - (35%)
Similarity:	321/617 - (52%)	Gaps:	110/617 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 VLTAPQRNSVQ----SVDIPGNEPERAAWSGKMQFFLSIIGYSVGLGNIWRFPYLCQQNGGGAFL 94
            :|...:.|.||    |.|  |:...|..|..|:.|.||::|::|.|.|:|||||||.:|||||||
  Rat    33 LLVVKEHNGVQCLLASQD--GDAQPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFL 95

  Fly    95 IPFMVMLILEGIPLFLIELGIGQRMRLGALGVWNTIHPWLGGIGISSCIVTLFVALYYNVIITWV 159
            ||:.:.||:.|:|||.:||.:||..|.||..||. |.|:..|:|.:..::.|:|..||||||.|.
  Rat    96 IPYTLFLIIAGMPLFYMELALGQFNREGAATVWK-ICPFFKGVGYAVILIALYVGFYYNVIIAWS 159

  Fly   160 FFYLFNSFRYPLPWSSCPLNGTGFELEECAK---------SSETTYFWYRTT------------L 203
            .:|||.||...|||::|   |..:....|..         ...|.|..|:.|            |
  Rat   160 LYYLFASFTLNLPWTNC---GHAWNSPNCTDPKLLNASVLGDHTKYSKYKFTPAAEFYERGVLHL 221

  Fly   204 DAAPSMDEPGGLKWWIVLCLMLSWTIVFFIVMKGIQSSGKVVYFTSLFPYIVLTIFFIRGITLRG 268
            ..:..:.:.|..:|.::||||:...:::|.:.||:::|||||:.|:..||.||.:..:.|:||.|
  Rat   222 HESSGIHDIGLPQWQLLLCLMVVIVVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPG 286

  Fly   269 AGAGLMHMYTPKVEKLLEPTVWLDAATQVFYSFGLAFGSLIAFGSYNTPKNNCVRDVLLVSVCNA 333
            |..|:.........:|.|.|||:|||||:|:|.|..||.||||.|||...|||.||.||.|..|.
  Rat   287 ASNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSTINC 351

  Fly   334 VTAIYASVVIFAILGFKATVNVDRCVASNTEILVKNKLLGLNDTQGYEQAMSLLNGTELLRLQLS 398
            ||:..:...||:|||:
  Rat   352 VTSFISGFAIFSILGY------------------------------------------------- 367

  Fly   399 ECSLAHE-----LDNAAEGTGLAFIVFTQAIVELPGAPFWAVLFFTMLLSLGLGSQIGILEGMLC 458
               :|||     .|.|.||.||.|:::.:||..|.|:.|||||||.|||:|||.|.:|.:|.::.
  Rat   368 ---MAHEHKVKIEDVATEGAGLVFVLYPEAISTLSGSTFWAVLFFLMLLALGLDSSMGGMEAVIT 429

  Fly   459 TLF-DIDIIKRVKKQHVTGVVCLFCFIVGFIFCTGAGEYWLKMFDSFAGTIGLVVVALMEMIAVI 522
            .|. |..::||.:|. .|..|.|..|::.....|..|.|.|.:.|:||....::...|||.|.|.
  Rat   430 GLADDFQVLKRHRKL-FTCAVTLGTFLLAMFCITKGGIYVLTLLDTFAAGTSILFAVLMEAIGVS 493

  Fly   523 FIYGHERFTEDIFQMTGYRPGRYWQWTWRYIGPVIMVCILVSSVV-FMVIRNPTYGAWNADLGMI 586
            :.||.:||:.||.||.|::||.||:..|:::.|..::.::|.|:: |..:   ||
  Rat   494 WFYGVDRFSNDIQQMMGFKPGLYWRLCWKFVSPAFLLFVVVVSIINFKPL---TY---------- 545

  Fly   587 EQKSYP---NWV-MGIALSMILAGVLPMPIVF 614
            :...||   ||| .|||||.::  ::|..:::
  Rat   546 DDYVYPPWANWVGWGIALSSMI--LVPAYVIY 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43066	NP_001246408.1	SLC6sbd-B0AT-like	55..617	CDD:271364	215/592 (36%)
Slc6a2	NP_112633.2	SLC5-6-like_sbd	56..615	CDD:382020	215/592 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810