Protein Alignment CG43066 and Slc6a1

DIOPT Version :9

• Sequence 1: NP_001246408.1
• Gene: CG43066 / 37129
• FlyBaseID: FBgn0262476
• Length: 721
• Species: Drosophila melanogaster
• Sequence 2: NP_077347.1
• Gene: Slc6a1 / 79212
• RGDID: 620533
• Length: 599
• Species: Rattus norvegicus
• Alignment Length: 634
• Identity: 217/634 - (34%)
• Similarity: 340/634 - (53%)
• Gaps: 85/634 - (13%)

  Fly    50 GNEPERAAWSGKMQFFLSIIGYSVGLGNIWRFPYLCQQNGGGAFLIPFMVMLILEGIPLFLIELG 114
            |:.|:|..|.|:..|.:|.:||::||||:|||||||.:|||||||||:.:.||..|:||||:|..
  Rat    39 GDLPDRDTWKGRFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECS 103

  Fly   115 IGQRMRLGALGVWNTIHPWLGGIGISSCIVTLFVALYYNVIITWVFFYLFNSFRYPLPWSSC--P 177
            :||...:|.||||. :.|...|:|:::.:::.::.:||.|||:|..:||:|||...|||..|  |
  Rat   104 LGQYTSIGGLGVWK-LAPMFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNP 167

  Fly   178 LNG----TGFELEECAK-SSETTYFWYRTTLDAAPSMDEPGGLKWWIVLCLMLSWTIVFFIVMKG 237
            .|.    :.:.|..... :|....||.|........:|:||.::|.:.:.|.::|.:|:|.:.||
  Rat   168 WNTDRCFSNYSLVNTTNMTSAVVEFWERNMHQMTDGLDKPGQIRWPLAITLAIAWVLVYFCIWKG 232

  Fly   238 IQSSGKVVYFTSLFPYIVLTIFFIRGITLRGAGAGLMHMYTPKVEKLLEPTVWLDAATQVFYSFG 302
            :..:||||||::.:|||:|.|.|.||:||.||..|::...||...||.:..||||||||:|:|:|
  Rat   233 VGWTGKVVYFSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQIFFSYG 297

  Fly   303 LAFGSLIAFGSYNTPKNNCVRDVLLVSVCNAVTAIYASVVIFAILGFKATVNVDRCVASNTEILV 367
            |..|||||.||||:..||..||.::|...|:.|:::|..|||:|:||.|.| ..|.:|
  Rat   298 LGLGSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAHV-TKRSIA------- 354

  Fly   368 KNKLLGLNDTQGYEQAMSLLNGTELLRLQLSECSLAHELDNAAEGTGLAFIVFTQAIVELPGAPF 432
                                                   |.||.|.||||:.:.:|:.:||.:|.
  Rat   355 ---------------------------------------DVAASGPGLAFLAYPEAVTQLPISPL 380

  Fly   433 WAVLFFTMLLSLGLGSQIGILEGMLCTLFD-IDIIKRVKKQHVTGVVCLFCFIVGFIFCTGAGEY 496
            ||:|||:|||.||:.||...:||.:..|.| ...:.|.:::.....||:..:::|....|..|.|
  Rat   381 WAILFFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNRRELFIAAVCIVSYLIGLSNITQGGIY 445

  Fly   497 WLKMFDSF-AGTIGLVVVALMEMIAVIFIYGHERFTEDIFQMTGYRPGRYWQWTWRYIGPVIMVC 560
            ..|:||.: |..:.|:.:...|.:::.:.||..||.::|.:|.|.||..:|:..|.:..|:|:..
  Rat   446 VFKLFDYYSASGMSLLFLVFFECVSISWFYGVNRFYDNIQEMVGSRPCIWWKLCWSFFTPIIVAG 510

  Fly   561 ILVSSVVFMVIRNP-TYGAWNADLGMIEQKSYPNWVMGIALSMILAGVLPMPIVFLMRSFQCLKV 624
            :.:.|.|.|   .| |.|::          .:|.|..|:...|.|:.::.:| .::...|..||
  Rat   511 VFLFSAVQM---TPLTMGSY----------VFPKWGQGVGWLMALSSMVLIP-GYMAYMFLTLK- 560

  Fly   625 DLDIHQGSIRRNETTASTKEMIDNDDDDDEDDENDFSGPALGGHVKTQS 673
                  ||:::.      .:::....:|....||....|..|.....::
  Rat   561 ------GSLKQR------LQVMIQPSEDIVRPENGPEQPQAGSSASKEA 597

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43066	NP_001246408.1	SLC6sbd-B0AT-like	55..617	CDD:271364	205/571 (36%)
Slc6a1	NP_077347.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23
		SLC6sbd_GAT1	2..599	CDD:212075	217/634 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	577..599		4/21 (19%)
		PDZ-binding	597..599		0/1 (0%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810