Protein Alignment CG43066 and Slc6a19

DIOPT Version :10

• Sequence 1: NP_001246408.1
• Gene: CG43066 / 37129
• FlyBaseID: FBgn0262476
• Length: 721
• Species: Drosophila melanogaster
• Sequence 2: NP_083154.1
• Gene: Slc6a19 / 74338
• MGIID: 1921588
• Length: 634
• Species: Mus musculus
• Alignment Length: 643
• Identity: 282/643 - (43%)
• Similarity: 412/643 - (64%)
• Gaps: 35/643 - (5%)

  Fly    31 VTIVLTAP----QRNSVQSVDIPGNEP--ERAAWSGKMQFFLSIIGYSVGLGNIWRFPYLCQQNG 89
            |.:||..|    :..|:..:::...|.  .|..|..|.|:.|:.:|:.|||||:||||||||.:|
Mouse     2 VRLVLPNPGLEERIPSLDELEVIEKEEAGSRPKWDNKAQYMLTCVGFCVGLGNVWRFPYLCQSHG 66

  Fly    90 GGAFLIPFMVMLILEGIPLFLIELGIGQRMRLGALGVWNTIHPWLGGIGISSCIVTLFVALYYNV 154
            ||||:|||:::|:.|||||..:|..||||:|.|::|||::|||.|.||||:|..|:..|.||||.
Mouse    67 GGAFMIPFLILLVFEGIPLLYLEFAIGQRLRKGSMGVWSSIHPALKGIGIASMFVSFMVGLYYNT 131

  Fly   155 IITWVFFYLFNSFRYPLPWSSCPL--NGTGFELEECAKSSETTYFWYRTTLDAAPSMDEPGGLKW 217
            ||.||.:|.||||:.|||||.|||  |.||: :|||||||...|||||.||:.:.|:.:.|.::|
Mouse   132 IIAWVMWYFFNSFQEPLPWSECPLNQNQTGY-VEECAKSSSVDYFWYRETLNISTSISDSGSIQW 195

  Fly   218 WIVLCLMLSWTIVFFIVMKGIQSSGKVVYFTSLFPYIVLTIFFIRGITLRGAGAGLMHMYTPKVE 282
            ||:|||..:|::::..:::||:::||.||.||..||:|||||.|||:||:||..|::.::||.:.
Mouse   196 WILLCLTCAWSVLYVCIIRGIETTGKAVYITSTLPYVVLTIFLIRGLTLKGATNGIVFLFTPNIT 260

  Fly   283 KLLEPTVWLDAATQVFYSFGLAFGSLIAFGSYNTPKNNCVRDVLLVSVCNAVTAIYASVVIFAIL 347
            :|..|..||||..||||||.||||.||:|.|||:..|||..|.::|||.|..|::||:.|:::|:
Mouse   261 ELSNPNTWLDAGAQVFYSFSLAFGGLISFSSYNSVHNNCEMDSVIVSVINGFTSVYAATVVYSII 325

  Fly   348 GFKATVNVDRCVASNTEILVKNKLLGLNDTQG---------YEQAMSLLNGTELLRLQLSECSLA 403
            ||:||...|.||.:|...|:.    |.:..:|         |:|..:..|.....:|:...|.:.
Mouse   326 GFRATERFDDCVNTNILTLIN----GFDLPEGNVTSENFEAYQQWCNATNPQAYAQLKFQTCDIN 386

  Fly   404 HELDNAAEGTGLAFIVFTQAIVELPGAPFWAVLFFTMLLSLGLGSQIGILEGMLCTLFDIDII-K 467
            ..|....|||||||||||:||.::|.:|.|:||||.||..|||.|..|.:||::..|.|::|. |
Mouse   387 SFLSEGVEGTGLAFIVFTEAITKMPVSPLWSVLFFIMLFCLGLSSMFGNMEGVVVPLQDLNITPK 451

  Fly   468 RVKKQHVTGVVCLFCFIVGFIFCTGAGEYWLKMFDSFAGTIGLVVVALMEMIAVIFIYGHERFTE 532
            :..|:.:||::||..:::.|||...:|:|||.:.|||||:|.|:::|..||.||:::||.:||.:
Mouse   452 KWPKELLTGLICLGTYLIAFIFTLNSGQYWLSLLDSFAGSIPLLIIAFCEMFAVVYVYGVDRFNK 516

  Fly   533 DIFQMTGYRPGRYWQWTWRYIGPVIMVCILVSSVVFMVIRNPTYGAWN---ADLGMIEQKSYPNW 594
            ||..|.|::|..:||.|||.:.|:||:.|.:...|..|.:...|..|:   .:....::..||||
Mouse   517 DIEFMIGHKPNIFWQVTWRVVSPLIMLVIFLFFFVIEVNKTLMYSIWDPNYEEFPKSQKIPYPNW 581

  Fly   595 VMGIALSMILAGV--LPMPIVFLMRSFQ--CLKVDLDIHQGSIRRNETTASTKEMIDN 648
            |..:.::  :|||  |.:|...:.:..:  |.|  .|.|.|.: ...:|||....:.|
Mouse   582 VYAVVVT--VAGVPCLSIPCFAIYKFIRNCCQK--SDDHHGLV-NTLSTASVNGDLKN 634

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43066	NP_001246408.1	SLC6sbd-B0AT-like	55..617	CDD:271364	267/578 (46%)
Slc6a19	NP_083154.1	SLC5-6-like_sbd	32..612	CDD:444915	268/586 (46%)