Protein Alignment CG43066 and slc6a4b

DIOPT Version :10

• Sequence 1: NP_001246408.1
• Gene: CG43066 / 37129
• FlyBaseID: FBgn0262476
• Length: 721
• Species: Drosophila melanogaster
• Sequence 2: NP_001170930.1
• Gene: slc6a4b / 664770
• ZFINID: ZDB-GENE-060314-2
• Length: 591
• Species: Danio rerio
• Alignment Length: 657
• Identity: 219/657 - (33%)
• Similarity: 332/657 - (50%)
• Gaps: 124/657 - (18%)

  Fly    12 NGHEMAPLNTRARGDGTHGVTIVLTAPQRNSVQSVDIPGNEPERAAWSGKMQFFLSIIGYSVGLG 76
            :|:..||......|..::.|.:::....|:.               ||.||.|.||:||::|.||
Zfish    10 HGNLCAPGPPNNAGYNSNPVPVIIQTESRDK---------------WSKKMDFLLSVIGFAVDLG 59

  Fly    77 NIWRFPYLCQQNGGGAFLIPFMVMLILEGIPLFLIELGIGQRMRLGALGVWNTIHPWLGGIGISS 141
            |:|||||:|.||||||||||:::|.:..|:|||.:||.:||..|.||:.:|..|.|...|||.:.
Zfish    60 NVWRFPYICYQNGGGAFLIPYVLMAVFGGVPLFYMELALGQFHRTGAISIWKHICPIFKGIGFAI 124

  Fly   142 CIVTLFVALYYNVIITWVFFYLFNSFRYPLPWSSCPLNGTGFELEECAKSSETTYF------WYR 200
            ||:.|:|:.|||.||.|..||.::||...|||:||   ...:..|.|     |.||      |
Zfish   125 CIIALYVSFYYNTIIAWALFYFYSSFSSTLPWTSC---DNDWNTENC-----TNYFGKDNVTW-- 179

  Fly   201 TTLDAAP----------SMDEPGGL------KWWIVLCLMLSWTIVFFIVMKGIQSSGKVVYFTS 249
            |....:|          ::.|..||      :|.::|||.|.:|||:|.:.||:::|||||:.|:
Zfish   180 TNYSRSPAEEFYTRNVLAVHESSGLGNVGYIRWQLMLCLFLIFTIVYFSLWKGVKTSGKVVWVTA 244

  Fly   250 LFPYIVLTIFFIRGITLRGAGAGLMHMYTPKVEKLLEPTVWLDAATQVFYSFGLAFGSLIAFGSY 314
            ..||:||.|..|||.||.||..|::....||.|||.|.:||:|||.|:|:|.|..||.|:|..||
Zfish   245 TLPYVVLLILMIRGATLPGAWKGVVFYLNPKWEKLKETSVWVDAAAQIFFSLGPGFGVLLALSSY 309

  Fly   315 NTPKNNCVRDVLLVSVCNAVTAIYASVVIFAILGFKATV-NVDRCVASNTEILVKNKLLGLNDTQ 378
            |...|||.||.::.|:.|.:|:..:..|||.:||:.|.. ||      |.|.:.::|
Zfish   310 NPFTNNCYRDAIVTSLVNCLTSFVSGFVIFTVLGYMAEQRNV------NVEDVARDK-------- 360

  Fly   379 GYEQAMSLLNGTELLRLQLSECSLAHELDNAAEGTGLAFIVFTQAIVELPGAPFWAVLFFTMLLS 443
                                             |..|.||.:.:||..:.|:.|:|::||.|:::
Zfish   361 ---------------------------------GPSLLFITYPEAIANMVGSTFFAIIFFVMMIT 392

  Fly   444 LGLGSQIGILEGMLCTLFD--IDIIKRVKKQHVTGVVCLFCFIVGFIFCTGAGEYWLKMFDSFAG 506
            |||.|..|.||.::..:.|  .|::...::..|.|:| :.||:......|..|.|.:|:.:.|..
Zfish   393 LGLDSTFGGLEAIITAVMDEYPDVLSHRRELFVLGLV-VVCFLGSLSTLTKGGAYVVKLLEEFGV 456

  Fly   507 TIGLVVVALMEMIAVIFIYGHERFTEDIFQMTGYRPGRYWQWTWRYIGPVIMVCILVSSVVFMVI 571
            ...::.:..:|..||.:.||..||:.||..|.||.||.:|:..|..|.|..:..|::||::
Zfish   457 GSSIIAIVFLEATAVSWFYGINRFSNDIKSMLGYTPGLFWKVCWVAISPAFLAYIIISSLL---- 517

  Fly   572 RNPTYGAWNADLGMIEQKSYPNWVMGIALSMILAGVLPMPIVFL-----------MRSFQCLKVD 625
             ||      ..|.:.:.: :|:|.:.:...:..:..:.:||..:           .|...||:.:
Zfish   518 -NP------QTLTLFDYE-FPDWSITVGYIIGASSFIWIPIYMVYKLVWTPGSLKQRLAVCLRPE 574

  Fly   626 L---DIH 629
            .   |||
Zfish   575 RTLPDIH 581

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43066	NP_001246408.1	SLC6sbd-B0AT-like	55..617	CDD:271364	207/597 (35%)
slc6a4b	NP_001170930.1	SLC6sbd_SERT	38..574	CDD:271399	211/620 (34%)