Protein Alignment CG43066 and SLC6A12

DIOPT Version :9

• Sequence 1: NP_001246408.1
• Gene: CG43066 / 37129
• FlyBaseID: FBgn0262476
• Length: 721
• Species: Drosophila melanogaster
• Sequence 2: NP_001116319.1
• Gene: SLC6A12 / 6539
• HGNCID: 11045
• Length: 614
• Species: Homo sapiens
• Alignment Length: 632
• Identity: 201/632 - (31%)
• Similarity: 321/632 - (50%)
• Gaps: 104/632 - (16%)

  Fly    54 ERAAWSGKMQFFLSIIGYSVGLGNIWRFPYLCQQNGGGAFLIPFMVMLILEGIPLFLIELGIGQR 118
            :|..|:.||:|.||:.|..:||||:|||||||.:||||||.||:.:...:.|||:|.:|:.:||.
Human    35 DRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFVCGIPVFFLEVALGQY 99

  Fly   119 MRLGALGVWNTIHPWLGGIGISSCIVTLFVALYYNVIITWVFFYLFNSFRYPLPWSSCPLNGTGF 183
            ...|::..|..|.|...|||::|.::..::.:||.:|:.|..||||:||...|||::|   ...:
Human   100 TSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAWALFYLFSSFTSELPWTTC---NNFW 161

  Fly   184 ELEECAK----------------SSETTYFWYRTTLDAAPSMDEPGGLKWWIVLCLMLSWTIVFF 232
            ..|.|..                :|....||.|..|.....:.:.|.|:|.:.|||:|:|.|.:|
Human   162 NTEHCTDFLNHSGAGTVTPFENFTSPVMEFWERRVLGITSGIHDLGSLRWELALCLLLAWVICYF 226

  Fly   233 IVMKGIQSSGKVVYFTSLFPYIVLTIFFIRGITLRGAGAGLMHMYTPKVEKLLEPTVWLDAATQV 297
            .:.||::|:|||||||:.|||::|.|..|||:||.||..|:::...|.:.:|.:|.||:||.||:
Human   227 CIWKGVKSTGKVVYFTATFPYLMLVILLIRGVTLPGAYQGIIYYLKPDLFRLKDPQVWMDAGTQI 291

  Fly   298 FYSFGLAFGSLIAFGSYNTPKNNCVRDVLLVSVCNAVTAIYASVVIFAILGFKATVNVDRCVASN 362
            |:||.:..|.|.|.||||...|||.:|.:.:...|:.|:..|..|:|:||||
Human   292 FFSFAICQGCLTALGSYNKYHNNCYKDCIALCFLNSATSFVAGFVVFSILGF------------- 343

  Fly   363 TEILVKNKLLGLNDTQGYEQAMSLLNGTELLRLQLSECSLAHELDNAAEGTGLAFIVFTQAIVEL 427
                       ::..||               :.:||.        |..|.|||||.|.:|:..:
Human   344 -----------MSQEQG---------------VPISEV--------AESGPGLAFIAFPKAVTMM 374

  Fly   428 PGAPFWAVLFFTMLLSLGLGSQIGILEGMLCTLFDI---DIIKRVKKQHVTGVVCLFCFIVGFIF 489
            |.:..|:.|||.||:.|||.||...:|.::....|:   .:.|..:::.:...:.:.|:::|...
Human   375 PLSQLWSCLFFIMLIFLGLDSQFVCVECLVTASIDMFPRQLRKSGRRELLILTIAVMCYLIGLFL 439

  Fly   490 CTGAGEYWLKMFDSFAGT-IGLVVVALMEMIAVIFIYGHERFTEDIFQMTGYRPGRYWQWTWRYI 553
            .|..|.|..::||.:|.: |.|:.::|.|::.:.::||.:||.::|..|.||||....:.:|.::
Human   440 VTEGGMYIFQLFDYYASSGICLLFLSLFEVVCISWVYGADRFYDNIEDMIGYRPWPLVKISWLFL 504

  Fly   554 GP-VIMVCILVSSVVFMVIR-NPTYGAWNADLGMIEQKSYPNWVMGIALSMILAGVLPMPIV--- 613
            .| :.:...|.|...:..:: |..|             .||.|...|...:.|:.::.:|:.
Human   505 TPGLCLATFLFSLSKYTPLKYNNVY-------------VYPPWGYSIGWFLALSSMVCVPLFVVI 556

  Fly   614 --------FLMRSFQCLKVDLDIHQ--------GSIRRNETTASTKE 644
                    |..|..|.:..|..:.|        ||..||...:.|:|
Human   557 TLLKTRGPFRKRLRQLITPDSSLPQPKQHPCLDGSAGRNFGPSPTRE 603

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43066	NP_001246408.1	SLC6sbd-B0AT-like	55..617	CDD:271364	191/594 (32%)
SLC6A12	NP_001116319.1	SLC6sbd_BGT1	35..575	CDD:212080	193/602 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	576..614		8/28 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810