DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43066 and SLC6A9

DIOPT Version :9

Sequence 1:	NP_001246408.1	Gene:	CG43066 / 37129	FlyBaseID:	FBgn0262476	Length:	721	Species:	Drosophila melanogaster
Sequence 2:	NP_964012.2	Gene:	SLC6A9 / 6536	HGNCID:	11056	Length:	706	Species:	Homo sapiens

Alignment Length:	677	Identity:	234/677 - (34%)
Similarity:	352/677 - (51%)	Gaps:	137/677 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 ERAAWSGKMQFFLSIIGYSVGLGNIWRFPYLCQQNGGGAFLIPFMVMLILEGIPLFLIELGIGQR 118
            :|..|..:::|.|:.:||:|||||:|||||||.:||||||:.|:.:|||..|||||.:||..||.
Human    99 KRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQF 163

  Fly   119 MRLGALGVWNTIHPWLGGIGISSCIVTLFVALYYNVIITWVFFYLFNSFRYPLPWSSC--PLNGT 181
            ...|.||||. |.|...|:|....:|:.::.:||||:|...|:|.|:|..:.|||:.|  |.|
Human   164 ASQGCLGVWR-ISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWN-- 225

  Fly   182 GFELEECA------------------------------KSSETTYFWYRTTLDAAPSMDEPGGLK 216
               ..:||                              ::|.:..:|....|..:..:...|.::
Human   226 ---THDCAGVLDASNLTNGSRPAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKLSDDIGNFGEVR 287

  Fly   217 WWIVLCLMLSWTIVFFIVMKGIQSSGKVVYFTSLFPYIVLTIFFIRGITLRGAGAGLMHMYTPKV 281
            ..::.||.:||.:||..:::|::|||||||||:.|||:||||.|:||:||.||..|:|:..||:.
Human   288 LPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFDGIMYYLTPQW 352

  Fly   282 EKLLEPTVWLDAATQVFYSFGLAFGSLIAFGSYNTPKNNCVRDVLLVSVCNAVTAIYASVVIFAI 346
            :|:||..||.|||:|:|||.|.|:|.||...|||...|||.||.:::|:.|..|::||..|||:|
Human   353 DKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSI 417

  Fly   347 LGFKATVNVDRCVASNTEILVKNKLLGLNDTQGYEQAMSLLNGTELLRLQLSECSLAHELDNAAE 411
            |||.|                 |.|                 |.::.|:             |..
Human   418 LGFMA-----------------NHL-----------------GVDVSRV-------------ADH 435

  Fly   412 GTGLAFIVFTQAIVELPGAPFWAVLFFTMLLSLGLGSQIGILEGMLCTLFDIDIIKRV------- 469
            |.||||:.:.:|:..||.:|.|::|||.||:.||||:|..:||.::..:.|     .|
Human   436 GPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVD-----EVGNEWILQ 495

  Fly   470 KKQHVTGVVCLFCFIVGFIFCTGAGEYWLKMFDSFAGTIGLVVVALMEMIAVIFIYGHERFTEDI 534
            ||.:||..|.:..|::|....:.||.|||.:.|::|.:..|||::.:..:|:::||||..:.:||
Human   496 KKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDI 560

  Fly   535 FQMTGYRPGRYWQWTWRYIGPVIMVCILVSSVV-FMVIRNPTYGAWNADLGMIEQKSYPNWVMGI 598
            ..|.|:.|..::|..||::.|.|:..|||.:|: :..|   ||..:          .||.|.:.|
Human   561 QMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPI---TYNHY----------QYPGWAVAI 612

  Fly   599 ALSMILAGVLPMPIVFLMRSFQCLKVDLDIHQGSIRRNETTASTKEMIDNDDDDDEDDENDFSGP 663
            ...|.|:.||.:|   |...|:..:.|.|.....: :|.|..|                .|: ||
Human   613 GFLMALSSVLCIP---LYAMFRLCRTDGDTLLQRL-KNATKPS----------------RDW-GP 656

  Fly   664 AL-----GGHVKTQSDFSDDDEEDKPM 685
            ||     |.:..|.:...:|..|.:|:
Human   657 ALLEHRTGRYAPTIAPSPEDGFEVQPL 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43066	NP_001246408.1	SLC6sbd-B0AT-like	55..617	CDD:271364	218/601 (36%)
SLC6A9	NP_964012.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
SLC6A9	NP_964012.2	SLC6sbd_GlyT1	84..667	CDD:212067	230/659 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810