DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG43066 and SLC6A4

DIOPT Version :9

Sequence 1:NP_001246408.1 Gene:CG43066 / 37129 FlyBaseID:FBgn0262476 Length:721 Species:Drosophila melanogaster
Sequence 2:NP_001036.1 Gene:SLC6A4 / 6532 HGNCID:11050 Length:630 Species:Homo sapiens


Alignment Length:674 Identity:219/674 - (32%)
Similarity:340/674 - (50%) Gaps:116/674 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 KIIDAP---------RNGHEMAPLNTRARGDGT-HGVTIVLTAPQRNSVQSVDIPGNEPERAAWS 59
            |::..|         .||:...|  :...||.| |.:      |...:....::  ::.||..|.
Human    29 KVVPTPGDKVESGQISNGYSAVP--SPGAGDDTRHSI------PATTTTLVAEL--HQGERETWG 83

  Fly    60 GKMQFFLSIIGYSVGLGNIWRFPYLCQQNGGGAFLIPFMVMLILEGIPLFLIELGIGQRMRLGAL 124
            .|:.|.||:|||:|.|||:|||||:|.||||||||:|:.:|.|..|||||.:||.:||..|.|.:
Human    84 KKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCI 148

  Fly   125 GVWNTIHPWLGGIGISSCIVTLFVALYYNVIITWVFFYLFNSFRYPLPWSSCPL-----NGTGFE 184
            .:|..|.|...|||.:.||:..::|.|||.|:.|..:||.:||...|||:||..     |.|.:.
Human   149 SIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYF 213

  Fly   185 LEE-----CAKSSETTYFWYRTTLD--AAPSMDEPGGLKWWIVLCLMLSWTIVFFIVMKGIQSSG 242
            .|:     ...:|....|:.|..|.  .:..:.:.||:.|.:.||:||.:|:::|.:.||:::||
Human   214 SEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSG 278

  Fly   243 KVVYFTSLFPYIVLTIFFIRGITLRGAGAGLMHMYTPKVEKLLEPTVWLDAATQVFYSFGLAFGS 307
            |||:.|:.||||:|::..:||.||.||..|::....|..:||||..||:|||.|:|:|.|..||.
Human   279 KVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGV 343

  Fly   308 LIAFGSYNTPKNNCVRDVLLVSVCNAVTAIYASVVIFAILGFKATVNVDRCVASNTEILVKNKLL 372
            |:||.|||...|||.:|.|:.||.|.:|:..:..|||.:||:.|                     
Human   344 LLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMA--------------------- 387

  Fly   373 GLNDTQGYEQAMSLLNGTELLRLQLSECSLAHELDNAAEGTGLAFIVFTQAIVELPGAPFWAVLF 437
                              |:....:||.:       ...|..|.||.:.:||..:|.:.|:|::|
Human   388 ------------------EMRNEDVSEVA-------KDAGPSLLFITYAEAIANMPASTFFAIIF 427

  Fly   438 FTMLLSLGLGSQIGILEGMLCTLFD--IDIIKRVKKQHVTGVVCLFCFIVGFIFCTGAGEYWLKM 500
            |.||::|||.|....|||::..:.|  ..:..:.:::.|..|| :.||....:..|..|.|.:|:
Human   428 FLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVV-ITCFFGSLVTLTFGGAYVVKL 491

  Fly   501 FDSFAGTIGLVVVALMEMIAVIFIYGHERFTEDIFQMTGYRPGRYWQWTWRYIGPVIMVCILVSS 565
            .:.:|....::.|||:|.:||.:.||..:|..|:.:|.|:.||.:|:..|..|.|:.::.|:.| 
Human   492 LEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFIICS- 555

  Fly   566 VVFMVIRNPTYGAWNADLGMIEQKSYPNW--VMG--------------IALSMILAGVLPMPIVF 614
               .::..|..        .:.|.:||.|  ::|              ||..:|:.     |..|
Human   556 ---FLMSPPQL--------RLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIIT-----PGTF 604

  Fly   615 LMRSFQCL--KVDLDIHQGSIRRN 636
            ..|..:.:  :...:|..|.||.|
Human   605 KERIIKSITPETPTEIPCGDIRLN 628

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG43066NP_001246408.1 SLC6sbd-B0AT-like 55..617 CDD:271364 202/591 (34%)
SLC6A4NP_001036.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..59 7/31 (23%)
5HT_transport_N 24..64 CDD:397524 9/42 (21%)
SLC6sbd_SERT 79..615 CDD:271399 203/599 (34%)
Interaction with RAB4A 616..624 1/7 (14%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.