Protein Alignment CG43066 and SLC6A3

DIOPT Version :9

• Sequence 1: NP_001246408.1
• Gene: CG43066 / 37129
• FlyBaseID: FBgn0262476
• Length: 721
• Species: Drosophila melanogaster
• Sequence 2: NP_001035.1
• Gene: SLC6A3 / 6531
• HGNCID: 11049
• Length: 620
• Species: Homo sapiens
• Alignment Length: 646
• Identity: 210/646 - (32%)
• Similarity: 329/646 - (50%)
• Gaps: 96/646 - (14%)

  Fly    26 DGTHGVTIVLTAPQRNSVQSVDIPGNEPERAAWSGKMQFFLSIIGYSVGLGNIWRFPYLCQQNGG 90
            :|....:..||.|:::.|::.|       |..|..|:.|.||:||::|.|.|:|||||||.:|||
Human    38 NGVQLTSSTLTNPRQSPVEAQD-------RETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGG 95

  Fly    91 GAFLIPFMVMLILEGIPLFLIELGIGQRMRLGALGVWNTIHPWLGGIGISSCIVTLFVALYYNVI 155
            ||||:|:::.:::.|:|||.:||.:||..|.||.|||. |.|.|.|:|.:..:::|:|..:||||
Human    96 GAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWK-ICPILKGVGFTVILISLYVGFFYNVI 159

  Fly   156 ITWVFFYLFNSFRYPLPWSSC---------------PLNGTGFELEECAKSSETTYFWYRTTLDA 205
            |.|...|||:||...|||..|               ..:|....|.:...::....::.|..|..
Human   160 IAWALHYLFSSFTTELPWIHCNNSWNSPNCSDAHPGDSSGDSSGLNDTFGTTPAAEYFERGVLHL 224

  Fly   206 APS--MDEPGGLKWWIVLCLMLSWTIVFFIVMKGIQSSGKVVYFTSLFPYIVLTIFFIRGITLRG 268
            ..|  :|:.|..:|.:..||:|...:::|.:.||:::|||||:.|:..||:|||...:||:||.|
Human   225 HQSHGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPG 289

  Fly   269 AGAGLMHMYTPKVEKLLEPTVWLDAATQVFYSFGLAFGSLIAFGSYNTPKNNCVRDVLLVSVCNA 333
            |..|:....:....:|.|.:||:||||||.:|.|:.||.||||.|||...|||.||.::.:..|:
Human   290 AIDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINS 354

  Fly   334 VTAIYASVVIFAILGFKATVNVDRCVASNTEILVKNKLLGLNDTQGYEQAMSLLNGTELLRLQLS 398
            :|:..:..|:|:.||:.|                              |..|:..|
Human   355 LTSFSSGFVVFSFLGYMA------------------------------QKHSVPIG--------- 380

  Fly   399 ECSLAHELDNAAEGTGLAFIVFTQAIVELPGAPFWAVLFFTMLLSLGLGSQIGILEGMLCTLFDI 463
                    |.|.:|.||.||::.:||..||.:..|||:||.|||:||:.|.:|.:|.::..|.|.
Human   381 --------DVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDE 437

  Fly   464 DIIKRVKKQHVTGVVCLFCFIVGFIFCTGAGEYWLKMFDSFAGTIGLVVVALMEMIAVIFIYGHE 528
            ..:....::..|..:.|..|::.....|..|.|...:.|.||....::...|:|.|.|.:.||..
Human   438 FQLLHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVG 502

  Fly   529 RFTEDIFQMTGYRPGRYWQWTWRYIGPVIMVCILVSSVVFMVIRNPTYGAWNADLGMIEQKSYPN 593
            :|::||.||||.||..||:..|:.:.|..::.::|.|:|  ..|.|.|||:          .:|:
Human   503 QFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSIV--TFRPPHYGAY----------IFPD 555

  Fly   594 WVMGIALSMILAGVLPMPIVFLMRSFQCLKVDLDIHQGSIRRNETTA----STKEMIDNDD 650
            |...:...:..:.:..:|| :....|..|       .||.|.....|    ..:|::|..:
Human   556 WANALGWVIATSSMAMVPI-YAAYKFCSL-------PGSFREKLAYAIAPEKDRELVDRGE 608

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43066	NP_001246408.1	SLC6sbd-B0AT-like	55..617	CDD:271364	196/578 (34%)
SLC6A3	NP_001035.1	SLC6sbd_DAT1	60..614	CDD:212083	204/617 (33%)
		Interaction with TGFB1I1. /evidence=ECO:0000269|PubMed:12177201	561..590		7/36 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810