Protein Alignment CG43066 and SLC6A2

DIOPT Version :10

• Sequence 1: NP_001246408.1
• Gene: CG43066 / 37129
• FlyBaseID: FBgn0262476
• Length: 721
• Species: Drosophila melanogaster
• Sequence 2: NP_001165975.1
• Gene: SLC6A2 / 6530
• HGNCID: 11048
• Length: 628
• Species: Homo sapiens
• Alignment Length: 660
• Identity: 232/660 - (35%)
• Similarity: 338/660 - (51%)
• Gaps: 134/660 - (20%)

  Fly     7 IDAPRNGHEMA---PLNTRARGDGTHGVTIVLTAPQRNSVQSVDIP--GNEPERAAWSGKMQFFL 66
            :....||.:..   ||..|...:       :|...:||.||.:..|  |:...|..|..|:.|.|
Human    10 VQPENNGADTGPEQPLRARKTAE-------LLVVKERNGVQCLLAPRDGDAQPRETWGKKIDFLL 67

  Fly    67 SIIGYSVGLGNIWRFPYLCQQNGGGAFLIPFMVMLILEGIPLFLIELGIGQRMRLGALGVWNTIH 131
            |::|::|.|.|:|||||||.:|||||||||:.:.||:.|:|||.:||.:||..|.||..||. |.
Human    68 SVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYNREGAATVWK-IC 131

  Fly   132 PWLGGIGISSCIVTLFVALYYNVIITWVFFYLFNSFRYPLPWSSCP-------------LNGTGF 183
            |:..|:|.:..::.|:|..||||||.|..:|||:||...|||:.|.             |||:
Human   132 PFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTWNSPNCTDPKLLNGS-- 194

  Fly   184 ELEECAKSSETTYFWYRTT------------LDAAPSMDEPGGLKWWIVLCLMLSWTIVFFIVMK 236
                 ...:.|.|..|:.|            |..:..:.:.|..:|.::||||:...:::|.:.|
Human   195 -----VLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLCLMVVVIVLYFSLWK 254

  Fly   237 GIQSSGKVVYFTSLFPYIVLTIFFIRGITLRGAGAGLMHMYTPKVEKLLEPTVWLDAATQVFYSF 301
            |:::|||||:.|:..||.||.:..:.|:||.||..|:.........:|.|.|||:|||||:|:|.
Human   255 GVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAATQIFFSL 319

  Fly   302 GLAFGSLIAFGSYNTPKNNCVRDVLLVSVCNAVTAIYASVVIFAILGFKA---TVNVDRCVASNT 363
            |..||.||||.|||...|||.||.||.|..|.:|:..:...||:|||:.|   .||::
Human   320 GAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFAIFSILGYMAHEHKVNIE------- 377

  Fly   364 EILVKNKLLGLNDTQGYEQAMSLLNGTELLRLQLSECSLAHELDNAAEGTGLAFIVFTQAIVELP 428
                                                       |.|.||.||.||::.:||..|.
Human   378 -------------------------------------------DVATEGAGLVFILYPEAISTLS 399

  Fly   429 GAPFWAVLFFTMLLSLGLGSQIGILEGMLCTLF-DIDIIKRVKKQHVTGVVCLFCFIVGF----- 487
            |:.||||:||.|||:|||.|.:|.:|.::..|. |..::||.:|        ||.|.|.|
Human   400 GSTFWAVVFFVMLLALGLDSSMGGMEAVITGLADDFQVLKRHRK--------LFTFGVTFSTFLL 456

  Fly   488 -IFC-TGAGEYWLKMFDSFAGTIGLVVVALMEMIAVIFIYGHERFTEDIFQMTGYRPGRYWQWTW 550
             :|| |..|.|.|.:.|:||....::...|||.|.|.:.||.:||:.||.||.|:|||.||:..|
Human   457 ALFCITKGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCW 521

  Fly   551 RYIGPVIMVCILVSSVV-FMVIRNPTYGAWNADLGMIEQKSYP---NWV-MGIALSMILAGVLPM 610
            :::.|..::.::|.|:: |..:   ||          :...:|   ||| .|||||.::  ::|:
Human   522 KFVSPAFLLFVVVVSIINFKPL---TY----------DDYIFPPWANWVGWGIALSSMV--LVPI 571

  Fly   611 PIVFLMRSFQ 620
            .:::...|.|
Human   572 YVIYKFLSTQ 581

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43066	NP_001246408.1	SLC6sbd-B0AT-like	55..617	CDD:271364	218/602 (36%)
SLC6A2	NP_001165975.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23		2/12 (17%)
		SLC6sbd_NET	56..612	CDD:212081	220/607 (36%)