Protein Alignment CG43066 and SLC6A1

DIOPT Version :9

• Sequence 1: NP_001246408.1
• Gene: CG43066 / 37129
• FlyBaseID: FBgn0262476
• Length: 721
• Species: Drosophila melanogaster
• Sequence 2: NP_001335179.1
• Gene: SLC6A1 / 6529
• HGNCID: 11042
• Length: 599
• Species: Homo sapiens
• Alignment Length: 631
• Identity: 219/631 - (34%)
• Similarity: 335/631 - (53%)
• Gaps: 104/631 - (16%)

  Fly    12 NGHEMAPLNTRARGDGTHGVTIVLTAPQRN--------SVQ--SVDIPGNEPERAAWSGKMQFFL 66
            ||.::|        ||... |.|..||..|        .||  :.|:    |:|..|.|:..|.:
Human     4 NGSKVA--------DGQIS-TEVSEAPVANDKPKTLVVKVQKKAADL----PDRDTWKGRFDFLM 55

  Fly    67 SIIGYSVGLGNIWRFPYLCQQNGGGAFLIPFMVMLILEGIPLFLIELGIGQRMRLGALGVWNTIH 131
            |.:||::||||:|||||||.:|||||||||:.:.||..|:||||:|..:||...:|.||||. :.
Human    56 SCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWK-LA 119

  Fly   132 PWLGGIGISSCIVTLFVALYYNVIITWVFFYLFNSFRYPLPWSSC--PLNGTGFELEECAK---- 190
            |...|:|:::.:::.::.:||.|||:|..:||:|||...|||..|  |.|     .:.|..
Human   120 PMFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWN-----TDRCFSNYSM 179

  Fly   191 ------SSETTYFWYRTTLDAAPSMDEPGGLKWWIVLCLMLSWTIVFFIVMKGIQSSGKVVYFTS 249
                  :|....||.|........:|:||.::|.:.:.|.::|.:|:|.:.||:..:||||||::
Human   180 VNTTNMTSAVVEFWERNMHQMTDGLDKPGQIRWPLAITLAIAWILVYFCIWKGVGWTGKVVYFSA 244

  Fly   250 LFPYIVLTIFFIRGITLRGAGAGLMHMYTPKVEKLLEPTVWLDAATQVFYSFGLAFGSLIAFGSY 314
            .:|||:|.|.|.||:||.||..|::...||...||.:..||||||||:|:|:||..|||||.|||
Human   245 TYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGLGSLIALGSY 309

  Fly   315 NTPKNNCVRDVLLVSVCNAVTAIYASVVIFAILGFKATVNVDRCVASNTEILVKNKLLGLNDTQG 379
            |:..||..||.::|...|:.|:::|..|||:|:||.|.| ..|.:|
Human   310 NSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAHV-TKRSIA------------------- 354

  Fly   380 YEQAMSLLNGTELLRLQLSECSLAHELDNAAEGTGLAFIVFTQAIVELPGAPFWAVLFFTMLLSL 444
                                       |.||.|.||||:.:.:|:.:||.:|.||:|||:|||.|
Human   355 ---------------------------DVAASGPGLAFLAYPEAVTQLPISPLWAILFFSMLLML 392

  Fly   445 GLGSQIGILEGMLCTLFD-IDIIKRVKKQHVTGVVCLFCFIVGFIFCTGAGEYWLKMFDSF-AGT 507
            |:.||...:||.:..|.| ...:.|.:::.....||:..:::|....|..|.|..|:||.: |..
Human   393 GIDSQFCTVEGFITALVDEYPRLLRNRRELFIAAVCIISYLIGLSNITQGGIYVFKLFDYYSASG 457

  Fly   508 IGLVVVALMEMIAVIFIYGHERFTEDIFQMTGYRPGRYWQWTWRYIGPVIMVCILVSSVVFM--- 569
            :.|:.:...|.:::.:.||..||.::|.:|.|.||..:|:..|.:..|:|:..:.:.|.|.|
Human   458 MSLLFLVFFECVSISWFYGVNRFYDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFIFSAVQMTPL 522

  Fly   570 VIRNPTYGAWNADLGMIEQKSYPNWVMGIALSMILAGVLPMPIVFL 615
            .:.|..:..|...:|         |:|.::..:::.|.  |..:||
Human   523 TMGNYVFPKWGQGVG---------WLMALSSMVLIPGY--MAYMFL 557

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43066	NP_001246408.1	SLC6sbd-B0AT-like	55..617	CDD:271364	205/578 (35%)
SLC6A1	NP_001335179.1	SLC6sbd_GAT1	2..599	CDD:212075	219/631 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	577..599
		PDZ-binding	597..599

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810