DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43066 and Slc6a17

DIOPT Version :9

Sequence 1:	NP_001246408.1	Gene:	CG43066 / 37129	FlyBaseID:	FBgn0262476	Length:	721	Species:	Drosophila melanogaster
Sequence 2:	NP_001028251.1	Gene:	Slc6a17 / 613226	RGDID:	1587185	Length:	727	Species:	Rattus norvegicus

Alignment Length:	634	Identity:	292/634 - (46%)
Similarity:	418/634 - (65%)	Gaps:	44/634 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 ERAAWSGKMQFFLSIIGYSVGLGNIWRFPYLCQQNGGGAFLIPFMVMLILEGIPLFLIELGIGQR 118
            :|.||:.|:|:.|:.||:|||||||||||||||:|||||:|:|::|:||:.|||||.:||.:|||
  Rat    59 DRPAWNSKLQYILAQIGFSVGLGNIWRFPYLCQKNGGGAYLVPYLVLLIIIGIPLFFLELAVGQR 123

  Fly   119 MRLGALGVWNTIHPWLGGIGISSCIVTLFVALYYNVIITWVFFYLFNSFRYPLPWSSCPL--NGT 181
            :|.|::|||:.:.|.|||||.|||||.|||.|||||||.|..||.|.||:||||||.||:  |||
  Rat   124 IRRGSIGVWHYVCPRLGGIGFSSCIVCLFVGLYYNVIIGWSVFYFFKSFQYPLPWSECPVIRNGT 188

  Fly   182 GFELE-ECAKSSETTYFWYRTTLDAAPSMDEPGGLKWWIVLCLMLSWTIVFFIVMKGIQSSGKVV 245
            ...:| ||.|||.|||||||..||.:.|:.|.|||.|.:.:||:::|:||...|:|||||||||:
  Rat   189 VAVVEPECEKSSATTYFWYREALDISNSISESGGLNWKMTVCLLVAWSIVGMAVVKGIQSSGKVM 253

  Fly   246 YFTSLFPYIVLTIFFIRGITLRGAGAGLMHMYTPKVEKLLEPTVWLDAATQVFYSFGLAFGSLIA 310
            ||:|||||:||..|.:||:.||||..|::||:|||::|:|:|.||.:||||||::.||.||.:||
  Rat   254 YFSSLFPYVVLACFLVRGLLLRGAVDGILHMFTPKLDKMLDPQVWREAATQVFFALGLGFGGVIA 318

  Fly   311 FGSYNTPKNNCVRDVLLVSVCNAVTAIYASVVIFAILGFKATVNVDRCVASNTEILVKNKLLG-L 374
            |.|||...|||..|..|||..|..|::.|::|:||:|||||.:..::||..|.|     |:|| |
  Rat   319 FSSYNKQDNNCHFDAALVSFINFFTSVLATLVVFAVLGFKANIMNEKCVVENAE-----KILGYL 378

  Fly   375 ND------------------TQGYEQAMSLL---NGTELLRLQLSECSLAHELDNAAEGTGLAFI 418
            |.                  |:.|.:..:::   ...:...|.|..|.|..|||.:.:|||||||
  Rat   379 NSNVLSRDLIPPHVNFSHLTTKDYSEMYNVIMTVKEKQFSALGLDPCLLEDELDKSVQGTGLAFI 443

  Fly   419 VFTQAIVELPGAPFWAVLFFTMLLSLGLGSQIGILEGMLCTLFDIDIIKRVKKQHVTGVVCLFCF 483
            .||:|:...|.:|||:|:||.||::|||||.||.:.|:...:  ||..| |.|:..|...|:|.|
  Rat   444 AFTEAMTHFPASPFWSVMFFLMLINLGLGSMIGTMAGITTPI--IDTFK-VPKEMFTVGCCVFAF 505

  Fly   484 IVGFIFCTGAGEYWLKMFDSFAGTIGLVVVALMEMIAVIFIYGHERFTEDIFQMTGYRPGRYWQW 548
            .||.:|...:|.|::.|||.::.|:.|.|:.::|.|||.:|||.::|.:::.:|.|:||.|::.:
  Rat   506 FVGLLFVQRSGNYFVTMFDDYSATLPLTVIVILENIAVAWIYGTKKFMQELTEMLGFRPYRFYFY 570

  Fly   549 TWRYIGPVIMVCILVSSVVFMVIRNPTYGAWNADLGMIEQKSYPNWVMGIALSMILAGVLPMPIV 613
            .|:::.|:.|..:..:|::.:.:..|.|.||..:........:|||.|.:.:::|....||:|:|
  Rat   571 MWKFVSPLCMAVLTTASIIQLGVSPPGYSAWIKEEAAERYLYFPNWAMALLITLIAVATLPIPVV 635

  Fly   614 FLMRSFQCLKVDLDIHQGSIRRNETTASTKE--MIDNDDDDDEDDENDF 660
            |::|.|..|.      .||   |..:.|.|:  |:.:..:.:|:||..|
  Rat   636 FILRHFHLLS------DGS---NTLSVSYKKGRMMKDISNLEENDETRF 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43066	NP_001246408.1	SLC6sbd-B0AT-like	55..617	CDD:271364	279/586 (48%)
Slc6a17	NP_001028251.1	SLC6sbd_NTT4	60..648	CDD:271403	282/601 (47%)
Slc6a17	NP_001028251.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	680..727
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	580	1.000	Domainoid score	I204
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H27775
Inparanoid	1	1.050	586	1.000	Inparanoid score	I966
OMA	1	1.010	-	-		QHG48419
OrthoDB	1	1.010	-	-		D251682at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm45479
orthoMCL	1	0.900	-	-		OOG6_101967
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1148
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.880