DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43066 and Slc6a14

DIOPT Version :9

Sequence 1:	NP_001246408.1	Gene:	CG43066 / 37129	FlyBaseID:	FBgn0262476	Length:	721	Species:	Drosophila melanogaster
Sequence 2:	NP_064433.3	Gene:	Slc6a14 / 56774	MGIID:	1890216	Length:	638	Species:	Mus musculus

Alignment Length:	680	Identity:	239/680 - (35%)
Similarity:	343/680 - (50%)	Gaps:	137/680 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 ERAAWSGKMQFFLSIIGYSVGLGNIWRFPYLCQQNGGGAFLIPFMVMLILEGIPLFLIELGIGQR 118
            ||..||.|..:.||::||:|||||:||||||...|||||||||:.:||.|.|:|||.:|..:||.
Mouse    35 ERGNWSKKSDYLLSMVGYAVGLGNVWRFPYLTYTNGGGAFLIPYAIMLALAGLPLFFLECSLGQF 99

  Fly   119 MRLGALGVWNTIHPWLGGIGISSCIVTLFVALYYNVIITWVFFYLFNSFRYPLPWSSC------- 176
            ..||.:.||. |.|...|:||:..::::|||:||||||.:..:|||.||:..|||::|
Mouse   100 ASLGPVSVWR-ILPLFQGVGITMVLISVFVAIYYNVIIAYSLYYLFASFQSVLPWANCSSWADEN 163

  Fly   177 ----PLNGTGFELE------------------ECAKSSE--------TTYFWYRTTLDAAPSMDE 211
                |: .||..:.                  .|...||        :..:|.:.||..:..|||
Mouse   164 CSRTPI-VTGCNVSIGAGEMFMNISWVNTNNLTCLNGSEVFRPGQLPSEQYWDKVTLQRSSGMDE 227

  Fly   212 PGGLKWWIVLCLMLSWTIVFFIVMKGIQSSGKVVYFTSLFPYIVLTIFFIRGITLRGAGAGLMHM 276
            .|.:.|::.|||:|:|.||...:.|||:|||||||||:||||:||.|..|||.||.||..|:.:.
Mouse   228 TGVVVWYLALCLLLAWLIVGAALFKGIKSSGKVVYFTALFPYVVLLILLIRGATLEGASKGISYY 292

  Fly   277 Y--TPKVEKLLEPTVWLDAATQVFYSFGLAFGSLIAFGSYNTPKNNCVRDVLLVSVCNAVTAIYA 339
            .  .....||.|..||.|||||:|||..:|:|.|:|..|||...|||..|.::|.:.|.:|:::|
Mouse   293 IGAQSNFTKLREAEVWKDAATQIFYSLSVAWGGLVALSSYNKFNNNCYSDAIIVCLTNCLTSVFA 357

  Fly   340 SVVIFAILGFKATVNVDRCVASNTEILVKNKLLGLNDTQGYEQAMSLLNGTELLRLQLSECSLAH 404
            ...||:|||.                                  |:.::|.|:.::..|
Mouse   358 GFAIFSILGH----------------------------------MAHISGKEVSQVVKS------ 382

  Fly   405 ELDNAAEGTGLAFIVFTQAIVELPGAPFWAVLFFTMLLSLGLGSQIGILEGMLCTLFDIDIIKRV 469
                   |..||||.:.:|:.:||..|||::|||.|||:|||.||...:|.:..|..|: ..|.:
Mouse   383 -------GFDLAFIAYPEALAQLPAGPFWSILFFFMLLTLGLDSQFASIETITTTFQDL-FPKAM 439

  Fly   470 KKQHV--TGVVCLFCFIVGFIFCTGAGEYWLKMFDSFAGTIGLVVVALMEMIAVIFIYGHERFTE 532
            |:..|  |...||..|::|.:..|.||.||:.:.|.|....|:::.|::|:..:|:|||..||.|
Mouse   440 KRMRVPITLGCCLILFLLGLLCVTQAGIYWVHLIDHFCAGWGILIAAILEIAGIIWIYGGNRFIE 504

  Fly   533 DIFQMTGYRPGRYWQW---TWRYIGPVIMVCILVSSVVFMVIRNPTYGAWNADLGMIEQKSYPNW 594
            ||..|.|.:...:|.|   .|..|.|:::..|||.|:|  ....|.|    ||:      .||:|
Mouse   505 DIEMMIGAKRWIFWLWWRACWFVITPILLSAILVWSLV--KFHRPDY----ADI------PYPDW 557

  Fly   595 VMGIALSMILAGVLPMPIV-----------FLMRSFQCLKVD------LDIHQGSIRRNETTAST 642
            .:.:...||:..::.:||:           .|.|...|.:..      |:.|:|...|
Mouse   558 GVALGWCMIIFCIIWIPIMAIIKIVQAEGNILQRIISCCRPASNWGPYLEKHRGERYR------- 615

  Fly   643 KEMIDNDDDDDEDDENDFSGPALGGHVKTQ 672
                   |..:...|.|...|.:.|..|.:
Mouse   616 -------DMAEPAKETDHEIPTISGSTKPE 638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43066	NP_001246408.1	SLC6sbd-B0AT-like	55..617	CDD:271364	226/616 (37%)
Slc6a14	NP_064433.3	SLC5-6-like_sbd	36..637	CDD:294310	237/676 (35%)
Slc6a14	NP_064433.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	618..638		5/19 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810