DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43066 and slc6a11a

DIOPT Version :9

Sequence 1:	NP_001246408.1	Gene:	CG43066 / 37129	FlyBaseID:	FBgn0262476	Length:	721	Species:	Drosophila melanogaster
Sequence 2:	NP_001091857.1	Gene:	slc6a11a / 558960	ZFINID:	ZDB-GENE-030131-3729	Length:	590	Species:	Danio rerio

Alignment Length:	614	Identity:	201/614 - (32%)
Similarity:	326/614 - (53%)	Gaps:	89/614 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 TAPQRNSVQSVDIPGNEPERAAWSGKMQFFLSIIGYSVGLGNIWRFPYLCQQNGGGAFLIPFMVM 100
            ::.:|...|..||  ...||..|:.|::|.|::.|..:||||:|||||||.:||||||.||:::.
Zfish     4 SSTRRTGNQQADI--TPEERGQWANKIEFLLTVAGAIIGLGNVWRFPYLCYKNGGGAFFIPYVLY 66

  Fly   101 LILEGIPLFLIELGIGQRMRLGALGVWNTIHPWLGGIGISSCIVTLFVALYYNVIITWVFFYLFN 165
            |:..|||||::|..:||....|.:..|..:.|...|:|.:|.::.::.::.|.:||.|.|.|||:
Zfish    67 LVTCGIPLFVLETSLGQYTSQGGIMCWRKVCPLFEGMGYASQLIIVYGSITYIIIIAWAFLYLFS 131

  Fly   166 SFRYPLPWSSC--PLN----------GTGFELEECAKSSETTY-FWYRTTLDAAPSMDEPGGLKW 217
            ||...|||:||  |.|          .:..||.....||.:.. ||:...|..:..::..|.::|
Zfish   132 SFNVELPWASCNNPWNTDTCIVLSGRNSSSELASPLNSSSSVMEFWHHRVLRLSSGVEHLGTVRW 196

  Fly   218 WIVLCLMLSWTIVFFIVMKGIQSSGKVVYFTSLFPYIVLTIFFIRGITLRGAGAGLMHMYTPKVE 282
            .:.|.|:|.|.:|:|.:.||::|:||.||||:.|||::|.|..:||:||.||..|:.:...|.:.
Zfish   197 DLALILLLVWILVYFCIWKGVKSTGKAVYFTATFPYVMLLILLLRGVTLPGALNGIYYYMYPDLT 261

  Fly   283 KLLEPTVWLDAATQVFYSFGLAFGSLIAFGSYNTPKNNCVRDVLLVSVCNAVTAIYASVVIFAIL 347
            :|.:|.||:||.||:|||:.:..|.|.:.||||...|||.||...:.:.|:.|:......||::|
Zfish   262 RLADPQVWMDAGTQIFYSYAICLGYLSSLGSYNQYNNNCYRDSFYLCLLNSGTSFLGGFAIFSVL 326

  Fly   348 GFKATVNVDRCVASNTEILVKNKLLGLNDTQGYEQAMSLLNGTELLRLQLSECSLAHELDNAAEG 412
            |..|                        ..||.:  :||:                     |..|
Zfish   327 GHMA------------------------QEQGVD--ISLV---------------------AESG 344

  Fly   413 TGLAFIVFTQAIVELPGAPFWAVLFFTMLLSLGLGSQIGILEGMLCTLFDI--DIIKR-VKKQHV 474
            .||.|||:.||:..||.:.||||.||.|::.|||.||...||.::.::.||  .:::| .:::.:
Zfish   345 PGLVFIVYPQAVTMLPLSQFWAVCFFIMIILLGLDSQFVGLESIMTSVTDIFPTVLRRGFRREML 409

  Fly   475 TGVVCLFCFIVGFIFCTGAGEYWLKMFDSF--AGTIGLVVVALMEMIAVIFIYGHERFTEDIFQM 537
            ...:||.|:.:|.:..|..|.|.:::||.:  :||. |:.:|..:.:|:.::||.:||.|:|..|
Zfish   410 LLGICLVCYFMGLLMITEGGLYIIQLFDHYVCSGTT-LLFLATCQSVAIGWVYGADRFYENIQDM 473

  Fly   538 TGYRPGRYWQWTWRYIGPVIMVCILVSSVVFMVIRNPTYGAWNADLGMIEQKSYPNWVMGIALSM 602
            .||:|....::.|.|:.|  .||  |.:.:|.:::       .:.|....:..||.|..||...:
Zfish   474 IGYKPWPMVKYCWLYVTP--SVC--VGTFIFSLVK-------YSPLKFNNKYMYPWWAYGIGWFL 527

  Fly   603 ILAGVLPMPIVFLMRSFQCLKVDLDIHQG 631
            .::.:..:||..:.:          :|:|
Zfish   528 AVSSLSLIPINMIYK----------LHKG 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43066	NP_001246408.1	SLC6sbd-B0AT-like	55..617	CDD:271364	194/579 (34%)
slc6a11a	NP_001091857.1	SLC6sbd-TauT-like	21..560	CDD:271387	196/595 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810