DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43066 and SLC6A20

DIOPT Version :9

Sequence 1:	NP_001246408.1	Gene:	CG43066 / 37129	FlyBaseID:	FBgn0262476	Length:	721	Species:	Drosophila melanogaster
Sequence 2:	NP_001372612.1	Gene:	SLC6A20 / 54716	HGNCID:	30927	Length:	603	Species:	Homo sapiens

Alignment Length:	588	Identity:	258/588 - (43%)
Similarity:	381/588 - (64%)	Gaps:	27/588 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 EPERAAWSGKMQFFLSIIGYSVGLGNIWRFPYLCQQNGGGAFLIPFMVMLILEGIPLFLIELGIG 116
            |..|..|:..:||..:.|.|:|||||:||||||||..|||:||:|:::|||:||:||..:||.:|
Human     2 EKARPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELAVG 66

  Fly   117 QRMRLGALGVWNTIHPWLGGIGISSCIVTLFVALYYNVIITWVFFYLFNSFRYPLPWSSCPLNG- 180
            ||||.|::|.|.||.|:|.|:|::|.:|:.|:::|||||..|.|:|||:||:.|||||.|||||
Human    67 QRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWSVCPLNGN 131

  Fly   181 -TGFELEECAKSSETTYFWYRTTLDAAPSMDEPGGLKWWIVLCLMLSWTIVFFIVMKGIQSSGKV 244
             ||:: |||.|:|.|.|||||.||:.:||:.|.||::|...|||:|:|.:|:..:::|.:|:|||
Human   132 HTGYD-EECEKASSTQYFWYRKTLNISPSLQENGGVQWEPALCLLLAWLVVYLCILRGTESTGKV 195

  Fly   245 VYFTSLFPYIVLTIFFIRGITLRGAGAGLMHMYTPK-----------VEKLLEPTVWLDAATQVF 298
            ||||:..||.||.|:.|||:||.||..|||:|:|||           :|:|..|..|::||||:|
Human   196 VYFTASLPYCVLIIYLIRGLTLHGATNGLMYMFTPKGSSALSLLAFQIEQLANPKAWINAATQIF 260

  Fly   299 YSFGLAFGSLIAFGSYNTPKNNCVRDVLLVSVCNAVTAIYASVVIFAILGFKATVNVDRCVASNT 363
            :|.||.|||||||.|||.|.|||.:..::||:.|:.|:|:||:|.|:|.|||||.|.:.|: ...
Human   261 FSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIFASIVTFSIYGFKATFNYENCL-KKV 324

  Fly   364 EILVKNKL---------LGLNDTQGYEQAMSLLNGTELLRLQLSECSLAHELDNAAEGTGLAFIV 419
            .:|:.|..         ..|...:||..:......:|:.. |:..|||..|||.|.:||||||||
Human   325 SLLLTNTFDLEDGFLTASNLEQVKGYLASAYPSKYSEMFP-QIKNCSLESELDTAVQGTGLAFIV 388

  Fly   420 FTQAIVELPGAPFWAVLFFTMLLSLGLGSQIGILEGMLCTLFDIDII-KRVKKQHVTGVVCLFCF 483
            :|:||..:..:..|:||:|.|||.||:||.:|....:|..|.|..|| ..:.|:.::|:|||...
Human   389 YTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLGNTAAILTPLTDSKIISSHLPKEAISGLVCLVNC 453

  Fly   484 IVGFIFCTGAGEYWLKMFDSFAGTIGLVVVALMEMIAVIFIYGHERFTEDIFQMTGYRPGRYWQW 548
            .:|.:|...||.||..:|:.:|.|:.|:::.|:|.|||.::||..||..|:..|||.....||:.
Human   454 AIGMVFTMEAGNYWFDIFNDYAATLSLLLIVLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKV 518

  Fly   549 TWRYIGPVIMVCILVSSVV-FMVIRNPTYGAWNADLGMIEQKSYPNWVMGIALSMILAGVLPMPI 612
            .|..:.|:::|.:.|..:. :::.....|.||:|..|.:..|.||.:.:.:...::.:..:.:|:
Human   519 MWAGVSPLLIVSLFVFYLSDYILTGTLKYQAWDASQGQLVTKDYPAYALAVIGLLVASSTMCIPL 583

  Fly   613 VFL 615
            ..|
Human   584 AAL 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43066	NP_001246408.1	SLC6sbd-B0AT-like	55..617	CDD:271364	257/585 (44%)
SLC6A20	NP_001372612.1	SLC6sbd_SIT1	2..588	CDD:271401	258/588 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4234
OMA	1	1.010	-	-		QHG48419
OrthoDB	1	1.010	-	-		D251682at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.840