Protein Alignment CG43066 and Slc6a8

DIOPT Version :10

• Sequence 1: NP_001246408.1
• Gene: CG43066 / 37129
• FlyBaseID: FBgn0262476
• Length: 721
• Species: Drosophila melanogaster
• Sequence 2: NP_059044.1
• Gene: Slc6a8 / 50690
• RGDID: 619711
• Length: 635
• Species: Rattus norvegicus
• Alignment Length: 632
• Identity: 216/632 - (34%)
• Similarity: 331/632 - (52%)
• Gaps: 107/632 - (16%)

  Fly    12 NGHEMAPLNTRARGDGTHGVTIVLTAP-QRNSVQSVDIPGNEPERAAWSGKMQFFLSIIGYSVGL 75
            :|.:.||    ::|||..|    |.|| .|.:|         |.|..|:.:|.|.:|.:|::|||
  Rat    25 SGPDGAP----SKGDGPAG----LGAPSSRLAV---------PPRETWTRQMDFIMSCVGFAVGL 72

  Fly    76 GNIWRFPYLCQQNGGGAFLIPFMVMLILEGIPLFLIELGIGQRMRLGALGVWNTIHPWLGGIGIS 140
            ||:|||||||.:||||.||||::::.::.|||:|.:|:.:||.|:.|::.||| |.|...|:|.:
  Rat    73 GNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEISLGQFMKAGSINVWN-ICPLFKGLGYA 136

  Fly   141 SCIVTLFVALYYNVIITWVFFYLFNSFRYPLPWSSC------PLNGTGFELEECA---------- 189
            |.::..:...||.:::.|.|:||..||...|||::|      |.....|..|:||
  Rat   137 SMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNTPDCVEIFRHEDCANASLANLTCD 201

  Fly   190 ----KSSETTYFWYRTTLDAAPSMDEPGGLKWWIVLCLMLSWTIVFFIVMKGIQSSGKVVYFTSL 250
                :.|....||....|..:..::.||.|.|.:.|||:..|.:|:|.|.||::|:||:||||:.
  Rat   202 QLADRRSPVIEFWENKVLRLSTGLEVPGALNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTAT 266

  Fly   251 FPYIVLTIFFIRGITLRGAGAGLMHMYTPKVEKLLEPTVWLDAATQVFYSFGLAFGSLIAFGSYN 315
            |||:||.:..:||:.|.||..|:::...|...||..|.||:||.||:|:|:.:..|:|.|.||||
  Rat   267 FPYVVLVVLLVRGVLLPGALDGIIYYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYN 331

  Fly   316 TPKNNCVRDVLLVSVCNAVTAIYASVVIFAILGFKATVNVDRCVASNTEILVKNKLLGLNDTQGY 380
            ...|||.:|.:::::.|:.|:.:|..|:|:||||.||
  Rat   332 RFNNNCYKDAIILALINSGTSFFAGFVVFSILGFMAT---------------------------- 368

  Fly   381 EQAMSLLNGTELLRLQLSECSLAHELDNAAEGTGLAFIVFTQAIVELPGAPFWAVLFFTMLLSLG 445
            ||.:                   |....|..|.|||||.:.:|:..:|.||.||.|||.|||.||
  Rat   369 EQGV-------------------HISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLG 414

  Fly   446 LGSQIGILEGMLCTLFDI---DIIKRVKKQHVTGVVCLFCFIVGFIFCTGAGEYWLKMFD--SFA 505
            |.||...:||.:..|.|:   ....|.:::....:.|..||::.....|..|.|..::||  |.:
  Rat   415 LDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYSAS 479

  Fly   506 GTIGLVVVALMEMIAVIFIYGHERFTEDIFQMTGYRPGRYWQWTWRYIGPVIMVCILVSSVVFM- 569
            ||. |:..|..|.:.|.::||.:||.:||..|.||||..:.:|.|.:..|::.:.|.:.:||:.
  Rat   480 GTT-LLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIFNVVYYK 543

  Fly   570 -VIRNPTYGAWNADLGMIEQKSYPNWVMGIALSMILAGVLPMPIVFL 615
             ::.|.||             .||.|...:..:..|:.:|.:|:..|
  Rat   544 PLVYNNTY-------------VYPWWGEAMGWAFALSSMLCVPLHLL 577

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43066	NP_001246408.1	SLC6sbd-B0AT-like	55..617	CDD:271364	203/588 (35%)
Slc6a8	NP_059044.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..47		10/29 (34%)
		SLC6sbd_CT1	52..621	CDD:271397	203/588 (35%)