Protein Alignment CG43066 and slc6a5

DIOPT Version :10

• Sequence 1: NP_001246408.1
• Gene: CG43066 / 37129
• FlyBaseID: FBgn0262476
• Length: 721
• Species: Drosophila melanogaster
• Sequence 2: NP_001009557.1
• Gene: slc6a5 / 494450
• ZFINID: ZDB-GENE-050105-2
• Length: 786
• Species: Danio rerio
• Alignment Length: 654
• Identity: 239/654 - (36%)
• Similarity: 349/654 - (53%)
• Gaps: 130/654 - (19%)

  Fly    27 GTHGVTIVL----TAPQRNSVQSV------DIPGNEPE-RAAWSGKMQFFLSIIGYSVGLGNIWR 80
            ||.|.|.||    |.|..:....:      |..|:|.: |..||.|:.|.||::||:|||||:||
Zfish   138 GTDGNTSVLPGTVTGPPTDDTGRLFQDDDDDDGGDENKARGNWSNKLDFILSMVGYAVGLGNVWR 202

  Fly    81 FPYLCQQNGGGAFLIPFMVMLILEGIPLFLIELGIGQRMRLGALGVWNTIHPWLGGIGISSCIVT 145
            ||||..||||||||||:::||.|.|||:||:|:.:||....|.:.||..| |.|.|.||:..|::
Zfish   203 FPYLAFQNGGGAFLIPYLIMLGLAGIPIFLLEVSLGQFASQGPVSVWKAI-PALQGCGIAMLIIS 266

  Fly   146 LFVALYYNVIITWVFFYLFNSFRYPLPWSSCPLNGTGFE--------LEEC-------AKSSETT 195
            :.:|:|||:|:.|..:|||.|.:..|||::|.......|        |:.|       .....||
Zfish   267 VLIAIYYNIIMCWTLYYLFASLKETLPWATCKNEWNTVECKDKDMLLLDTCILRDRNITSIKNTT 331

  Fly   196 ------------------------------YFWYRTTLDAAPSMDEPGGLKWWIVLCLMLSWTIV 230
                                          ||.| ..|..:..::.||.::|.:..||.|:|.||
Zfish   332 FCLSANVVGNLSKLLNVTVDNKTYVSPSEEYFKY-NVLHISKGIEYPGDIRWPLAACLFLAWLIV 395

  Fly   231 FFIVMKGIQSSGKVVYFTSLFPYIVLTIFFIRGITLRGAGAGLMHMYTPKVEKLLEPTVWLDAAT 295
            :..:.|||:|||||||||:.|||:||.|..|||:||.|||:|:::..|||.|||.:..||.||||
Zfish   396 YASLAKGIKSSGKVVYFTATFPYVVLVILLIRGVTLPGAGSGILYFITPKWEKLNDAKVWKDAAT 460

  Fly   296 QVFYSFGLAFGSLIAFGSYNTPKNNCVRDVLLVSVCNAVTAIYASVVIFAILGFKATVNVDRCVA 360
            |:|:|...|:|.||...|||...|||.||.|:|:..|:.|:|:|..|||:::||
Zfish   461 QIFFSLSAAWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGF----------- 514

  Fly   361 SNTEILVKNKLLGLNDTQGYEQAMSLLNGTELLRLQLSECSLAHEL-----DNAAEGTGLAFIVF 420
                                                     :||||     ..|.||.|:||:|:
Zfish   515 -----------------------------------------MAHELKVPIESVADEGPGIAFVVY 538

  Fly   421 TQAIVELPGAPFWAVLFFTMLLSLGLGSQIGILEGMLCTLFDIDIIK--RVKKQHVTGVVCLFCF 483
            .:|:..||.:||||::||.|||:|||.:....:|.::.::.| :..|  |..|...|.|.||..|
Zfish   539 PEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSVSD-EFPKYLRKHKPQFTLVCCLSFF 602

  Fly   484 IVGFIFCTGAGEYWLKMFDSFAGTIGLVVVALMEMIAVIFIYGHERFTEDIFQMTGYRPGRYWQW 548
            ::||...|.:|.|.|::.|:||.:..||::|:.|::.:.:|||.:||.|||..|.|::|.::|:.
Zfish   603 VLGFPMITESGMYMLQLVDTFAASYSLVIIAIFELVGISYIYGLQRFCEDIEMMIGFQPNKFWRV 667

  Fly   549 TWRYIGPVIMVCILVSSVVFMVIRNPTYGAWNADLGMIEQKSYPNWVMGIALSMILAGVLPMPIV 613
            .|.::.|.|:..||..|:....:.  ||          |..:||||.|.:...|::..|:.:||:
Zfish   668 CWAFVTPTILTFILALSLYQWKVM--TY----------EDYTYPNWSMVLGWLMVICSVIWIPIM 720

  Fly   614 FLMR 617
            |.::
Zfish   721 FAIK 724

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43066	NP_001246408.1	SLC6sbd-B0AT-like	55..617	CDD:271364	228/613 (37%)
slc6a5	NP_001009557.1	SLC5-6-like_sbd	177..775	CDD:444915	228/615 (37%)