Protein Alignment CG43066 and SLC6A17

DIOPT Version :9

• Sequence 1: NP_001246408.1
• Gene: CG43066 / 37129
• FlyBaseID: FBgn0262476
• Length: 721
• Species: Drosophila melanogaster
• Sequence 2: NP_001010898.1
• Gene: SLC6A17 / 388662
• HGNCID: 31399
• Length: 727
• Species: Homo sapiens
• Alignment Length: 634
• Identity: 292/634 - (46%)
• Similarity: 420/634 - (66%)
• Gaps: 44/634 - (6%)

  Fly    54 ERAAWSGKMQFFLSIIGYSVGLGNIWRFPYLCQQNGGGAFLIPFMVMLILEGIPLFLIELGIGQR 118
            :|.||:.|:|:.|:.||:|||||||||||||||:|||||:|:|::|:||:.|||||.:||.:|||
Human    59 DRPAWNSKLQYILAQIGFSVGLGNIWRFPYLCQKNGGGAYLVPYLVLLIIIGIPLFFLELAVGQR 123

  Fly   119 MRLGALGVWNTIHPWLGGIGISSCIVTLFVALYYNVIITWVFFYLFNSFRYPLPWSSCPL--NGT 181
            :|.|::|||:.|.|.|||||.|||||.|||.|||||||.|..||.|.||:||||||.||:  ||:
Human   124 IRRGSIGVWHYICPRLGGIGFSSCIVCLFVGLYYNVIIGWSIFYFFKSFQYPLPWSECPVVRNGS 188

  Fly   182 GFELE-ECAKSSETTYFWYRTTLDAAPSMDEPGGLKWWIVLCLMLSWTIVFFIVMKGIQSSGKVV 245
            ...:| ||.|||.|||||||..||.:.|:.|.|||.|.:.|||:::|:||...|:|||||||||:
Human   189 VAVVEAECEKSSATTYFWYREALDISDSISESGGLNWKMTLCLLVAWSIVGMAVVKGIQSSGKVM 253

  Fly   246 YFTSLFPYIVLTIFFIRGITLRGAGAGLMHMYTPKVEKLLEPTVWLDAATQVFYSFGLAFGSLIA 310
            ||:|||||:||..|.:||:.||||..|::||:|||::|:|:|.||.:||||||::.||.||.:||
Human   254 YFSSLFPYVVLACFLVRGLLLRGAVDGILHMFTPKLDKMLDPQVWREAATQVFFALGLGFGGVIA 318

  Fly   311 FGSYNTPKNNCVRDVLLVSVCNAVTAIYASVVIFAILGFKATVNVDRCVASNTEILVKNKLLG-L 374
            |.|||...|||..|..|||..|..|::.|::|:||:|||||.:..::||..|.|     |:|| |
Human   319 FSSYNKQDNNCHFDAALVSFINFFTSVLATLVVFAVLGFKANIMNEKCVVENAE-----KILGYL 378

  Fly   375 N------------------DTQGYEQAMSLL---NGTELLRLQLSECSLAHELDNAAEGTGLAFI 418
            |                  .|:.|.:..:::   ...:...|.|..|.|..|||.:.:|||||||
Human   379 NTNVLSRDLIPPHVNFSHLTTKDYMEMYNVIMTVKEDQFSALGLDPCLLEDELDKSVQGTGLAFI 443

  Fly   419 VFTQAIVELPGAPFWAVLFFTMLLSLGLGSQIGILEGMLCTLFDIDIIKRVKKQHVTGVVCLFCF 483
            .||:|:...|.:|||:|:||.||::|||||.||.:.|:...:  ||..| |.|:..|...|:|.|
Human   444 AFTEAMTHFPASPFWSVMFFLMLINLGLGSMIGTMAGITTPI--IDTFK-VPKEMFTVGCCVFAF 505

  Fly   484 IVGFIFCTGAGEYWLKMFDSFAGTIGLVVVALMEMIAVIFIYGHERFTEDIFQMTGYRPGRYWQW 548
            :||.:|...:|.|::.|||.::.|:.|.::.::|.|||.:|||.::|.:::.:|.|:||.|::.:
Human   506 LVGLLFVQRSGNYFVTMFDDYSATLPLTLIVILENIAVAWIYGTKKFMQELTEMLGFRPYRFYFY 570

  Fly   549 TWRYIGPVIMVCILVSSVVFMVIRNPTYGAWNADLGMIEQKSYPNWVMGIALSMILAGVLPMPIV 613
            .|:::.|:.|..:..:|::.:.:..|.|.||..:........:|||.|.:.:::|:...||:|:|
Human   571 MWKFVSPLCMAVLTTASIIQLGVTPPGYSAWIKEEAAERYLYFPNWAMALLITLIVVATLPIPVV 635

  Fly   614 FLMRSFQCLKVDLDIHQGSIRRNETTASTKE--MIDNDDDDDEDDENDF 660
            |::|.|..|.      .||   |..:.|.|:  |:.:..:.:|:||..|
Human   636 FVLRHFHLLS------DGS---NTLSVSYKKGRMMKDISNLEENDETRF 675

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43066	NP_001246408.1	SLC6sbd-B0AT-like	55..617	CDD:271364	279/586 (48%)
SLC6A17	NP_001010898.1	SLC6sbd_NTT4	60..648	CDD:271403	282/601 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	680..727

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	581	1.000	Domainoid score	I212
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H27775
Inparanoid	1	1.050	585	1.000	Inparanoid score	I1008
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48419
OrthoDB	1	1.010	-	-		D251682at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41353
orthoMCL	1	0.900	-	-		OOG6_101967
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1148
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.880