Protein Alignment CG43066 and SLC6A18

DIOPT Version :9

• Sequence 1: NP_001246408.1
• Gene: CG43066 / 37129
• FlyBaseID: FBgn0262476
• Length: 721
• Species: Drosophila melanogaster
• Sequence 2: NP_872438.2
• Gene: SLC6A18 / 348932
• HGNCID: 26441
• Length: 628
• Species: Homo sapiens
• Alignment Length: 624
• Identity: 273/624 - (43%)
• Similarity: 400/624 - (64%)
• Gaps: 40/624 - (6%)

  Fly    54 ERAAWSGKMQFFLSIIGYSVGLGNIWRFPYLCQQNGGGAFLIPFMVMLILEGIPLFLIELGIGQR 118
            ||..|..|.|:.||..|::||||||||||||||..||||||||:::.|:.||||:|.:||.||||
Human    17 ERPKWDNKAQYLLSCTGFAVGLGNIWRFPYLCQTYGGGAFLIPYVIALVFEGIPIFHVELAIGQR 81

  Fly   119 MRLGALGVWNTIHPWLGGIGISSCIVTLFVALYYNVIITWVFFYLFNSFRYPLPWSSCP--LNGT 181
            :|.|::|||..|.|:|.|:|:....::..::||||.|:.||.:||.|||::||||||||  ||.|
Human    82 LRKGSVGVWTAISPYLSGVGLGCVTLSFLISLYYNTIVAWVLWYLLNSFQHPLPWSSCPPDLNRT 146

  Fly   182 GFELEECAKSSETTYFWYRTTLDAAPSMDEPGGLKWWIVLCLMLSWTIVFFIVMKGIQSSGKVVY 246
            || :|||..||..:|||||.||:....:::.|.::||:::||..||.:|:..|::||:::|||:|
Human   147 GF-VEECQGSSAVSYFWYRQTLNITADINDSGSIQWWLLICLAASWAVVYMCVIRGIETTGKVIY 210

  Fly   247 FTSLFPYIVLTIFFIRGITLRGAGAGLMHMYTPKVEKLLEPTVWLDAATQVFYSFGLAFGSLIAF 311
            ||:||||:|||||.|||:||.||..||::::||.:..|..|.||||||||:|:|..||||..|||
Human   211 FTALFPYLVLTIFLIRGLTLPGATKGLIYLFTPNMHILQNPRVWLDAATQIFFSLSLAFGGHIAF 275

  Fly   312 GSYNTPKNNCVRDVLLVSVCNAVTAIYASVVIFAILGFKATVNVDRCVASNTEILVKNKLLGLND 376
            .|||:|:|:|.:|.:::::.|.:|::|||:.:|::||||||.:.:.|       |.:|.|..:||
Human   276 ASYNSPRNDCQKDAVVIALVNRMTSLYASIAVFSVLGFKATNDYEHC-------LDRNILSLIND 333

  Fly   377 TQGYEQAMSL---------LNGT---ELLRLQLSECSLAHELDNAAEGTGLAFIVFTQAIVELPG 429
            ....||::|.         ||.|   .:.:|.|..|.|...||.:|.|.||||:|||:..:.:||
Human   334 FDFPEQSISRDDYPAVLMHLNATWPKRVAQLPLKACLLEDFLDKSASGPGLAFVVFTETDLHMPG 398

  Fly   430 APFWAVLFFTMLLSLGLGSQIGILEGMLCTLFDIDIIKR-VKKQHVTGVVCLFCFIVGFIFCTGA 493
            ||.||:|||.||.:|||.:..|.:|.::..|.|:.::.| |.|:.:||:|||.||:....|...:
Human   399 APVWAMLFFGMLFTLGLSTMFGTVEAVITPLLDVGVLPRWVPKEALTGLVCLVCFLSATCFTLQS 463

  Fly   494 GEYWLKMFDSFAGTIGLVVVALMEMIAVIFIYGHERFTEDIFQMTGYRPGRYWQWTWRYIGPVIM 558
            |.|||::||:||.:..|:::|.:|::.|:::||.:||.:||..|||.||..||:.|||.:.|:::
Human   464 GNYWLEIFDNFAASPNLLMLAFLEVVGVVYVYGMKRFCDDIAWMTGRRPSPYWRLTWRVVSPLLL 528

  Fly   559 VCILVSSVVFMVIRNPTYGAWNADLGMI---EQKSYPNWVMGIALSMILAGVLPMPIVFLMRSFQ 620
            . |.|:.::.:..:...|.|||....:.   ::|.||.|.....:.:.|..||.:|:..|.
Human   529 T-IFVAYIILLFWKPLRYKAWNPKYELFPSRQEKLYPGWARAACVLLSLLPVLWVPVAALA---- 588

  Fly   621 CLKVDLDIHQGSIRRNETTASTKEMIDNDDDDDEDDEND 659
                     |...||..|........|.|...|.|...|
Human   589 ---------QLLTRRRRTWRDRDARPDTDMRPDTDTRPD 618

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43066	NP_001246408.1	SLC6sbd-B0AT-like	55..617	CDD:271364	263/579 (45%)
SLC6A18	NP_872438.2	SLC6sbd_B0AT3	17..591	CDD:212086	265/595 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	602..628		5/17 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48419
OrthoDB	1	1.010	-	-		D251682at33208
OrthoFinder	1	1.000	-	-		FOG0001784
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101967
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4904
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.820