DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43066 and CG15279

DIOPT Version :9

Sequence 1:	NP_001246408.1	Gene:	CG43066 / 37129	FlyBaseID:	FBgn0262476	Length:	721	Species:	Drosophila melanogaster
Sequence 2:	NP_609726.1	Gene:	CG15279 / 34863	FlyBaseID:	FBgn0028886	Length:	639	Species:	Drosophila melanogaster

Alignment Length:	619	Identity:	191/619 - (30%)
Similarity:	299/619 - (48%)	Gaps:	109/619 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 RNSVQSVDIPGNEP----------------ERAAWSGKMQFFLSIIGYSVGLGNIWRFPYLCQQN 88
            |::..:|:|..|.|                |||.|...::|.:|.|..||||||:||||:....|
  Fly    19 RSTASTVEISTNSPALRDNSDDQEAAKVPEERATWGKGVEFLMSCIAMSVGLGNVWRFPFTALDN 83

  Fly    89 GGGAFLIPFMVMLILEGIPLFLIELGIGQRMRLGALGVWNTIHPWLGGIGISSCIVTLFVALYYN 153
            ||||||||::::|.|.|.|::.:|:.|||....|::.|:: :.|.:.|:|.........::.||.
  Fly    84 GGGAFLIPYLIVLFLIGKPIYYLEMVIGQFSSRGSVKVFD-LCPAMKGVGAGQAFQVFMLSTYYA 147

  Fly   154 VIITWVFFYLFNSFRYPLPWSSC------------PLNGTGFELEE--------CAKSSE----T 194
            .::..:..|...|||.|||||:|            |......:||.        ..||..    |
  Fly   148 ALVAIIGRYFIESFRNPLPWSTCRAEWGIHCINSAPDASNWSQLESNDQRPQNYTMKSQNDRVIT 212

  Fly   195 TYFWY--RTTLDAAPSMDEPGGL-KWWIVLCLMLSWTIVFFIVMKGIQSSGKVVYFTSLFPYIVL 256
            :..||  :..|...|:::|..|| .|.:|:.|.::|:.||||:.:|::||||..||.:||||:::
  Fly   213 SSEWYFVKEVLHEKPNIEEGIGLPNWELVIGLFIAWSCVFFIIRRGVKSSGKASYFLALFPYVIM 277

  Fly   257 TIFFIRGITLRGAGAGLMHMYTPKVEKLLEPTVWLDAATQVFYSFGLAFGSLIAFGSYNTPKNNC 321
            .:..:|.:||.|:..|:.:...|:..|:|:|.||..|.||.|||..:.||::|.:.|:|...:|.
  Fly   278 GVLLVRAVTLPGSIDGIYYFIKPQWGKILDPKVWYAAVTQCFYSLSVCFGNIIMYSSFNKFGHNV 342

  Fly   322 VRDVLLVSVCNAVTAIYASVVIFAILGFKATVNVDRCVASNTEILVKNKLLGLNDTQGYEQAMSL 386
            .||..:|:..:.:|::.|...||.|||..|           .||             |.:...|:
  Fly   343 HRDAAIVTGLDTMTSLLAGFTIFGILGHLA-----------HEI-------------GTDDIGSV 383

  Fly   387 LNGTELLRLQLSECSLAHELDNAAEGTGLAFIVFTQAIVELPGAP-FWAVLFFTMLLSLGLGSQI 450
            :.|                      |.|||||.:..||.:....| .::||||.||..||:||.|
  Fly   384 VKG----------------------GAGLAFISYPDAIAKFKNLPQIFSVLFFLMLFVLGIGSNI 426

  Fly   451 GILEGMLCTLFDI-DIIKRVKKQHVTGVVCLFCFIVGFIFCTGAGEYWLKMFDSFAGTIGLVVVA 514
            .:..   |::..| |......:...:.::.:..|.:|.::.|..|:|.|.:.|.|..::..:|:.
  Fly   427 AMTS---CSVTAIRDRFPNFGQWQCSLLIAVVSFFIGLMYITPGGQYMLTLVDFFGASMIALVLG 488

  Fly   515 LMEMIAVIFIYGHERFTEDIFQMTGYRPGRYWQWTWRYIGPVIMVCILVSSVVFMVIRNP-TYGA 578
            :.|:..:.:|||.:|..:||..|.|.:.|.||:..|..|.|:||..||   :.|.....| ||
  Fly   489 IAELYTIGWIYGTDRLCKDIEFMLGRKVGLYWRLCWSIITPLIMTVIL---IYFYATYQPLTY-- 548

  Fly   579 WNADLGMIEQKSYPNWVMGIALSMILAGVLPMPI 612
                    ....||||...|...:...|:|.:||
  Fly   549 --------NNIVYPNWSYSIGWLITAFGILQLPI 574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43066	NP_001246408.1	SLC6sbd-B0AT-like	55..617	CDD:271364	185/588 (31%)
CG15279	NP_609726.1	SLC5-6-like_sbd	50..598	CDD:294310	185/588 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440725
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840