Protein Alignment CG43066 and SLC6A19

DIOPT Version :10

• Sequence 1: NP_001246408.1
• Gene: CG43066 / 37129
• FlyBaseID: FBgn0262476
• Length: 721
• Species: Drosophila melanogaster
• Sequence 2: NP_001003841.1
• Gene: SLC6A19 / 340024
• HGNCID: 27960
• Length: 634
• Species: Homo sapiens
• Alignment Length: 614
• Identity: 280/614 - (45%)
• Similarity: 409/614 - (66%)
• Gaps: 32/614 - (5%)

  Fly    55 RAAWSGKMQFFLSIIGYSVGLGNIWRFPYLCQQNGGGAFLIPFMVMLILEGIPLFLIELGIGQRM 119
            |..|..|.|:.|:.:|:.|||||:||||||||.:|||||:|||:::|:||||||..:|..||||:
Human    32 RPKWDNKAQYMLTCLGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVLEGIPLLYLEFAIGQRL 96

  Fly   120 RLGALGVWNTIHPWLGGIGISSCIVTLFVALYYNVIITWVFFYLFNSFRYPLPWSSCPL--NGTG 182
            |.|:||||::|||.|.|:|::|.:.:..|.||||.||:|:.:||||||:.|||||.|||  |.||
Human    97 RRGSLGVWSSIHPALKGLGLASMLTSFMVGLYYNTIISWIMWYLFNSFQEPLPWSDCPLNENQTG 161

  Fly   183 FELEECAKSSETTYFWYRTTLDAAPSMDEPGGLKWWIVLCLMLSWTIVFFIVMKGIQSSGKVVYF 247
            : ::|||:||...|||||.||:.:.|:.:.|.::||::|||..:|::::...::||:::||.||.
Human   162 Y-VDECARSSPVDYFWYRETLNISTSISDSGSIQWWMLLCLACAWSVLYMCTIRGIETTGKAVYI 225

  Fly   248 TSLFPYIVLTIFFIRGITLRGAGAGLMHMYTPKVEKLLEPTVWLDAATQVFYSFGLAFGSLIAFG 312
            ||..||:|||||.|||:||:||..|::.::||.|.:|.:|..||||..|||:||.||||.||:|.
Human   226 TSTLPYVVLTIFLIRGLTLKGATNGIVFLFTPNVTELAQPDTWLDAGAQVFFSFSLAFGGLISFS 290

  Fly   313 SYNTPKNNCVRDVLLVSVCNAVTAIYASVVIFAILGFKATVNVDRCVASNTEILVKN-KLLGLND 376
            |||:..|||.:|.::||:.|..|::|.::|:::::||:||...|.|.::|...|:.. .|...|.
Human   291 SYNSVHNNCEKDSVIVSIINGFTSVYVAIVVYSVIGFRATQRYDDCFSTNILTLINGFDLPEGNV 355

  Fly   377 TQ----GYEQAMSLLNGTELLRLQLSECSLAHELDNAAEGTGLAFIVFTQAIVELPGAPFWAVLF 437
            ||    ..:|..:..:.....:|....|.:...|..|.|||||||||||:||.::|.:|.|:|||
Human   356 TQENFVDMQQRCNASDPAAYAQLVFQTCDINAFLSEAVEGTGLAFIVFTEAITKMPLSPLWSVLF 420

  Fly   438 FTMLLSLGLGSQIGILEGMLCTLFDIDII-KRVKKQHVTGVVCLFCFIVGFIFCTGAGEYWLKMF 501
            |.||..|||.|..|.:||::..|.|:.:| .:..|:.:||::||..|::||||...:|:|||.:.
Human   421 FIMLFCLGLSSMFGNMEGVVVPLQDLRVIPPKWPKEVLTGLICLGTFLIGFIFTLNSGQYWLSLL 485

  Fly   502 DSFAGTIGLVVVALMEMIAVIFIYGHERFTEDIFQMTGYRPGRYWQWTWRYIGPVIMVCILVSSV 566
            ||:||:|.|:::|..||.:|:::||.:||.:||..|.|::|..:||.|||.:.|::|:.|.:...
Human   486 DSYAGSIPLLIIAFCEMFSVVYVYGVDRFNKDIEFMIGHKPNIFWQVTWRVVSPLLMLIIFLFFF 550

  Fly   567 VFMVIRNPTYGAWNADLGMIE----QK-SYPNWVMGIALSMILAGV--LPMP---IVFLMRSFQC 621
            |..|.:..||..|  |.|..|    || ||||||..:.  :|:|||  |.:|   |..|:|: .|
Human   551 VVEVSQELTYSIW--DPGYEEFPKSQKISYPNWVYVVV--VIVAGVPSLTIPGYAIYKLIRN-HC 610

  Fly   622 LKVDLDIHQGSIRRNETTASTKEMIDNDD 650
            .|.  ..|||.:    :|.||..|  |.|
Human   611 QKP--GDHQGLV----STLSTASM--NGD 631

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43066	NP_001246408.1	SLC6sbd-B0AT-like	55..617	CDD:271364	268/579 (46%)
SLC6A19	NP_001003841.1	SLC5-6-like_sbd	32..612	CDD:444915	270/585 (46%)