DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43066 and ine

DIOPT Version :9

Sequence 1:	NP_001246408.1	Gene:	CG43066 / 37129	FlyBaseID:	FBgn0262476	Length:	721	Species:	Drosophila melanogaster
Sequence 2:	NP_001162871.1	Gene:	ine / 33659	FlyBaseID:	FBgn0011603	Length:	943	Species:	Drosophila melanogaster

Alignment Length:	592	Identity:	186/592 - (31%)
Similarity:	306/592 - (51%)	Gaps:	89/592 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 EPERAAWSGKMQFFLSIIGYSVGLGNIWRFPYLCQQNGGGAFLIPFMVMLILEGIPLFLIELGIG 116
            :|.:..|:.||||.|:.|||||||||:|||||:|.::|||.||:|:.::|.:..|||..:||.:|
  Fly   334 KPRQQHWANKMQFVLACIGYSVGLGNVWRFPYMCYKSGGGVFLVPYCIILFICSIPLLFMELSVG 398

  Fly   117 QRMRLGALGVWNTIHPWLGGIGISSCIVTLFVALYYNVIITWVFFYLFNSFRYPLPWSSCPLNGT 181
            |....|.:|....:.|...|.|::|.:|:..::.||:|||.:..:|.|.||:..:||..|   ..
  Fly   399 QYTGRGPIGALGQLCPLFKGAGLASVVVSFLMSTYYSVIIGYSIYYFFTSFKTEMPWIDC---NN 460

  Fly   182 GFELEEC---------AKSSETT-----YFWYRTTLDAAPSMDEPGGLKWWIVLCLMLSWTIVFF 232
            .:...:|         |.:.:|:     .|:....|..:..::.||.::|.:..||:.:|.:|:|
  Fly   461 RWNTPDCWVPQRKGINASAPDTSRTPSEEFFENKVLQISGGLEYPGMMRWELFACLICAWLMVYF 525

  Fly   233 IVMKGIQSSGKVVYFTSLFPYIVLTIFFIRGITLRGAGAGLMHMYTPKVEKLLEPTVWLDAATQV 297
            ...|.|:||.||.|||:.||::::.|..:|.:||.||..||...:.||..:|....||::||:|.
  Fly   526 ATWKSIKSSAKVRYFTATFPFVLIIILMVRAVTLDGAAEGLRFFFRPKWSELKNANVWINAASQN 590

  Fly   298 FYSFGLAFGSLIAFGSYNTPKNNCVRDVLLVSVCNAVTAIYASVVIFAILGFKATVNVDRCVASN 362
            |.|.|:.|||:|:|.|||...||.:||.:.||..|.:|::...:..|:.||       :..:..|
  Fly   591 FNSLGITFGSMISFASYNKYNNNILRDTVAVSAVNMITSLLVGIFAFSTLG-------NLALEQN 648

  Fly   363 TEILVKNKLLGLNDTQGYEQAMSLLNGTELLRLQLSECSLAHELDNAAEGTGLAFIVFTQAIVEL 427
            |.:                                        .|...:|.|:.|:|:.||:.::
  Fly   649 TNV----------------------------------------RDVIGDGPGMIFVVYPQAMAKM 673

  Fly   428 PGAPFWAVLFFTMLLSLGLGSQIGILEGMLCTLFDIDIIKRVKKQHV--TGVVCLFCFIVGFIF- 489
            |.|..|||:||.|||.|||.||..|:|.::.::  .|...|..|:|:  ..:|.||..::..:|
  Fly   674 PYAQLWAVMFFFMLLCLGLNSQFAIVEVVVTSI--QDGFPRWIKRHLGYHEIVVLFVCVISCLFG 736

  Fly   490 ---CTGAGEYWLKMFDSFAGTIGLVVVALMEMIAVIFIYGHERFTEDIFQMTGYRPGRYWQWTWR 551
               ....|.|:.::.|.:|.::.::.:|..:|||:.:.||..|.::::.||||..|..|.:..|.
  Fly   737 MPNIIQGGIYYFQLMDHYAASVTIMFLAFCQMIAIAWFYGTGRLSKNVKQMTGKAPSFYLRSCWL 801

  Fly   552 YIGPVIMVCILVSSVVFMVIRNPTY--GAWNADLGMIEQKSYPNWVMGIALSMILAGVLPMP--- 611
            .:||.::..|.|.|::  ....|||  |.:          :||:|..||........::.:|
  Fly   802 VLGPCLLFAIWVLSLI--NYHEPTYHNGRY----------TYPDWAYGIGWMFASFSLICIPGYA 854

  Fly   612 IVFLMRS 618
            ::..:||
  Fly   855 VINFLRS 861

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43066	NP_001246408.1	SLC6sbd-B0AT-like	55..617	CDD:271364	183/586 (31%)
ine	NP_001162871.1	SLC5-6-like_sbd	337..876	CDD:294310	185/589 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440740
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840