Protein Alignment CG43066 and Slc6a7

DIOPT Version :10

• Sequence 1: NP_001246408.1
• Gene: CG43066 / 37129
• FlyBaseID: FBgn0262476
• Length: 721
• Species: Drosophila melanogaster
• Sequence 2: XP_006525992.1
• Gene: Slc6a7 / 240332
• MGIID: 2147363
• Length: 684
• Species: Mus musculus
• Alignment Length: 691
• Identity: 238/691 - (34%)
• Similarity: 349/691 - (50%)
• Gaps: 133/691 - (19%)

  Fly    33 IVLTAPQRNSVQ-SVDIPGNEPERAAWSGKMQFFLSIIGYSVGLGNIWRFPYLCQQNGGGAFLIP 96
            :::|...:..|. .||...   :|..|:||:.|.||.|||.|||||:|||||....|||||||:|
Mouse    64 LLMTPSDQGDVDLDVDFAA---DRGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGAFLVP 125

  Fly    97 FMVMLILEGIPLFLIELGIGQRMRLGALGVWNTIHPWLGGIGISSCIVTLFVALYYNVIITWVFF 161
            :.:||.:.|||||.:||.:||...||.|.||. |.|...|.|.:..::...||:|||:||.:|.|
Mouse   126 YFLMLAICGIPLFFLELSLGQFSSLGPLAVWK-ISPLFKGAGAAMLLIVGLVAIYYNMIIAYVLF 189

  Fly   162 YLFNSFRYPLPWSSC--------------PLNGTG---FELEECAKSSETTYFWYRTTLDAAPSM 209
            |||.|....|||..|              |.:|.|   ..|......||..:..|...:..:..:
Mouse   190 YLFASLTSNLPWEHCGNWWNTELCLEHRGPKSGNGVLPLNLSSTVSPSEEYWSRYVLHIQGSQGI 254

  Fly   210 DEPGGLKWWIVLCLMLSWTIVFFIVMKGIQSSGKVVYFTSLFPYIVLTIFFIRGITLRGAGAGLM 274
            ..||.::|.:.|||:|:|.|||..::||::|||||||||:.|||::|.:..:||:||.||..|:.
Mouse   255 GRPGEIRWNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLILLMLLVRGVTLPGAWKGIQ 319

  Fly   275 HMYTPKVEKLLEPTVWLDAATQVFYSFGLAFGSLIAFGSYNTPKNNCVRDVLLVSVCNAVTAIYA 339
            ...||:...||...||::||.|:|||.|:.||.|:.|.||||...|..||..:|::.||:|:|.|
Mouse   320 FYLTPQFHHLLSSKVWIEAALQIFYSLGVGFGGLLTFASYNTFHQNIYRDTFIVTLGNAITSILA 384

  Fly   340 SVVIFAILGFKAT---VNVDRCVASNTEILVKNKLLGLNDTQGYEQAMSLLNGTELLRLQLSECS 401
            ...||::||:.:.   |.||:.
Mouse   385 GFAIFSVLGYMSQELGVPVDQV------------------------------------------- 406

  Fly   402 LAHELDNAAEGTGLAFIVFTQAIVELPGAPFWAVLFFTMLLSLGLGSQIGILEGMLCTLFD-IDI 465
                   |..|.||||:|:.||:..||.:|||:.|||.|||:|||.||...||.::..:.| ...
Mouse   407 -------AKAGPGLAFVVYPQAMTMLPLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDEFPY 464

  Fly   466 IKRVKKQHVTGVVCLFCFIVGFIFCTGAGEYWLKMFDSFAGTIGLVVVALMEMIAVIFIYGHERF 530
            ..|.||...:|::|:..:::|.|..|..|.|||.:.|.::.:.||:||.:...:||..:||.:||
Mouse   465 YLRPKKAVFSGLICVAMYLMGLILTTDGGMYWLVLLDDYSASFGLMVVVITTCLAVTRVYGIQRF 529

  Fly   531 TEDIFQMTGYRPGRYWQWTWRYIGPVIMVCILVSSVVFMVIRNPTYGAWNADLGMIEQKSYPNW- 594
            ..||..|.|::||.|::..|.::.|..::.:||.|:|  ..:...||::.          :|.|
Mouse   530 CRDIHMMLGFKPGLYFRACWLFLSPATLLALLVYSIV--KYQPSEYGSYR----------FPAWA 582

  Fly   595 -VMGIALS-----MILAGVLPMPIVFLMRSFQCLKVDLDIHQGSIRRNETTASTKEMIDNDDDDD 653
             ::||.:.     ||.||:|    |.::|           .:||:......||...|
Mouse   583 ELLGILMGLLSCLMIPAGML----VAVLR-----------EEGSLWERLQQASRPAM-------- 624

  Fly   654 EDDENDFSGPAL-----GGHVKTQSDFSDDDEEDKPMTMRM 689
                 |: ||:|     |.:|.|.:    ..:..||:.:.|
Mouse   625 -----DW-GPSLEENRTGMYVATLA----GSQSPKPLMVHM 655

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43066	NP_001246408.1	SLC6sbd-B0AT-like	55..617	CDD:271364	218/589 (37%)
Slc6a7	XP_006525992.1	SLC5-6-like_sbd	84..628	CDD:444915	225/635 (35%)