DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43066 and snf-12

DIOPT Version :9

Sequence 1:	NP_001246408.1	Gene:	CG43066 / 37129	FlyBaseID:	FBgn0262476	Length:	721	Species:	Drosophila melanogaster
Sequence 2:	NP_509527.1	Gene:	snf-12 / 181143	WormBaseID:	WBGene00004911	Length:	1022	Species:	Caenorhabditis elegans

Alignment Length:	752	Identity:	182/752 - (24%)
Similarity:	304/752 - (40%)	Gaps:	188/752 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 VQSVDIPGNE---PERAAWSGKMQ-------------------------FFLSIIGYSVGLGNIW 79
            :|::|:...|   |:|..|..:.|                         ||||.:|:.||:|:..
Worm   117 IQTIDVSALEDQTPQRPHWWDQFQLYRRTDLLRFSKQNDRRELWRTQKDFFLSCLGFMVGVGHTM 181

  Fly    80 RFPYLCQQNGGGAFLIPFMVMLILEGIPLFLIELGIGQRMRLGALGVWNTIHPWLGGIGISSCIV 144
            |||....|:|||.|.||::..||..|:||..:.|.:||.....|...:..:.|...|:|.:..::
Worm   182 RFPAKVYQHGGGVFFIPYLFSLIFFGLPLVFLHLSLGQYTGQAANTAFQRLMPIGSGVGWALVVI 246

  Fly   145 TLFVALYYNVIITWVFFYLFNSFR-----YPLPWSSC----PLNG---TGFELEECAKSSET--- 194
            .:.||:|||:|:.|...|.|.|.:     ..|||.:|    .|:.   ....|..|..|:.:
Worm   247 AIPVAVYYNIIVAWAIHYFFQSAKGLLLGDELPWETCRDEWQLDNRCCNLHNLHSCFNSTNSITA 311

  Fly   195 -TYFWYRTTLDAAPSMD-EPGGLKWWIVLCLMLSWTIVFFIVMKGIQSSGKVVYFTSLFPYIVLT 257
             ..|::...|..:...| ..|.|:..:||.|..:|.:|||.|.||:.|..:.:..|:..||::|:
Worm   312 PEAFFHSEVLSLSTFGDFALGPLQSHLVLSLAAAWLLVFFGVFKGLGSIAQTMNVTATVPYLLLS 376

  Fly   258 IFFIRGITLRGAGAGLMHMYTPKVEKLLEPTVWLDAATQVFYSFGLAFGSLIAFGSYNTPKNNCV 322
            |..:|||:|.||..||..::|....||.:..:|..||.||||..|:..|.||:..:::..:||..
Worm   377 ILLLRGISLPGANKGLTFLFTVDSTKLWKWQIWKSAAEQVFYELGIDAGPLISMAAFSRYRNNIY 441

  Fly   323 RDVLLVSVCNAVTAIYASVVIFAILGFKATVNVDRCVASNTEILVKNKLLGLNDTQGYEQAMSLL 387
            ||.:|:.:.:|:|:..:.:|||:.:||.|:       .||:.:         ||.
Worm   442 RDSVLLVIMDALTSCLSGMVIFSFVGFIAS-------ESNSNV---------NDV---------- 480

  Fly   388 NGTELLRLQLSECSLAHELDNAAEGTGLAFIVFTQAIVELPGAPFWAVLFFTMLLSLGLGSQIGI 452
                          |.|      :...|:|.|:......:.....||.|||.||:...:.::...
Worm   481 --------------LKH------DPLYLSFTVYPGVTSFMYWGGLWATLFFGMLVLAAIDAEFAW 525

  Fly   453 LEGMLCTLF--DIDIIKRVKKQHVTGVVCLFCFIVGFIFCTGAGEYWLKMFDSFAGTIGLVVVAL 515
            || |:.:.|  ...:..:..:..:...:||..|.:|...|...|.:.....::.........:||
Worm   526 LE-MIASAFMNHFSMKNKAVENRLLAFLCLAGFFLGLPLCAQGGIFVFHAIENLNANWNSFSLAL 589

  Fly   516 MEMIAVIFIYGHERFTEDIFQMTG-------------------YRPGR-YWQWTWRYIGPVIMVC 560
            :.:..|.::||.:.:..||..|..                   :.||. |.:::..:|.|||:..
Worm   590 LSVAIVCYVYGIDNYLTDISAMLRVPRIQISKATRLKEKLIYFFGPGGIYIKFSLCFICPVILTV 654

  Fly   561 ILVSSVVFMVIRNPTYGAWNADLGMIEQKSYPN-----------WVMGIALSMILAGVLPMPIVF 614
            :||:||                || .::.|:..           |:      :::..:|.:|:|.
Worm   655 LLVASV----------------LG-YQRISFAGRPIPIDYEIVAWI------VMIGPLLVVPLVA 696

  Fly   615 LMRSFQCLKVDLDIHQGSIRRNETTASTKEMIDNDDDDDEDDENDFSGPALGGHVKTQSDFSDDD 679
            .|:..|.             |||... .|.:.|..:                     ..:..||.
Worm   697 FMQIRQI-------------RNEGKL-LKSLFDTSE---------------------WRESQDDS 726

  Fly   680 EEDKPMTMRM--MMMRPTTTTKTSNVLNVPTSRKNNY 714
            .|.|.:.||.  ....|....:|..:.   |.|:|.|
Worm   727 LEPKDLYMRQSGKFESPPNRRRTPTIF---THRENTY 760

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43066	NP_001246408.1	SLC6sbd-B0AT-like	55..617	CDD:271364	159/636 (25%)
snf-12	NP_509527.1	SLC6sbd	158..660	CDD:271359	147/548 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810