Protein Alignment CG43066 and Slc6a5

DIOPT Version :9

• Sequence 1: NP_001246408.1
• Gene: CG43066 / 37129
• FlyBaseID: FBgn0262476
• Length: 721
• Species: Drosophila melanogaster
• Sequence 2: NP_976079.1
• Gene: Slc6a5 / 171148
• RGDID: 621824
• Length: 799
• Species: Rattus norvegicus
• Alignment Length: 643
• Identity: 236/643 - (36%)
• Similarity: 346/643 - (53%)
• Gaps: 116/643 - (18%)

  Fly    27 GTHGVTIVLTAPQRNSVQSVDIPGNE-----PERAAWSGKMQFFLSIIGYSVGLGNIWRFPYLCQ 86
            ||.|:..||.    .||.:..||.:|     ..|..||.|:.|.||::||:|||||:||||||..
  Rat   164 GTDGIASVLP----GSVATTTIPEDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAF 224

  Fly    87 QNGGGAFLIPFMVMLILEGIPLFLIELGIGQRMRLGALGVWNTIHPWLGGIGISSCIVTLFVALY 151
            ||||||||||:::||.|.|:|:|.:|:.:||....|.:.||..| |.|.|.||:..|:::.:|:|
  Rat   225 QNGGGAFLIPYLMMLALAGLPIFFLEVSLGQFASQGPVSVWKAI-PALQGCGIAMLIISVLIAIY 288

  Fly   152 YNVIITWVFFYLFNSFRYPLPWSSC--PLN------GTGFELEECA------------------- 189
            |||||.:..||||.||...|||.||  |.|      .|...|:.|.
  Rat   289 YNVIICYTLFYLFASFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVIGDHPKIQIKNSTFCMTAY 353

  Fly   190 ----------------KSSETTYFWYRTTLDAAPSMDEPGGLKWWIVLCLMLSWTIVFFIVMKGI 238
                            .|....||.| ..|..:..::.||.::|.:..||.|:|.||:..:.|||
  Rat   354 PNLTMVNFTSQANKTFVSGSEEYFKY-FVLKISAGIEYPGEIRWPLPFCLFLAWVIVYASLAKGI 417

  Fly   239 QSSGKVVYFTSLFPYIVLTIFFIRGITLRGAGAGLMHMYTPKVEKLLEPTVWLDAATQVFYSFGL 303
            ::||||||||:.|||:||.|..|||:||.|||||:.:..|||.|||.:.|||.|||||:|:|...
  Rat   418 KTSGKVVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSA 482

  Fly   304 AFGSLIAFGSYNTPKNNCVRDVLLVSVCNAVTAIYASVVIFAILGFKATVNVDRCVASNTEILVK 368
            |:|.||...|||...|||.||.|:|:..|:.|:|:|..|||:::||         :|:..::.::
  Rat   483 AWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGF---------MANERKVNIE 538

  Fly   369 NKLLGLNDTQGYEQAMSLLNGTELLRLQLSECSLAHELDNAAEGTGLAFIVFTQAIVELPGAPFW 433
            |.                                      |.:|.|:||:|:.:|:..||.:|||
  Rat   539 NV--------------------------------------ADQGPGIAFVVYPEALTRLPLSPFW 565

  Fly   434 AVLFFTMLLSLGLGSQIGILEGMLCTLFDIDIIK--RVKKQHVTGVVCLFCFIVGFIFCTGAGEY 496
            |::||.|||:|||.:....:|.::.::.| :..|  |..|...|...|:..||:||...|..|.|
  Rat   566 AIIFFLMLLTLGLDTMFATIETIVTSISD-EFPKYLRTHKPVFTLGCCICFFIMGFPMITQGGIY 629

  Fly   497 WLKMFDSFAGTIGLVVVALMEMIAVIFIYGHERFTEDIFQMTGYRPGRYWQWTWRYIGPVIMVCI 561
            ..::.|::|.:..||::|:.|::.:.::||.:||.|||..|.|::|..:|:..|.::.|.|:..|
  Rat   630 MFQLVDTYAASYALVIIAIFELVGISYVYGLQRFCEDIEMMIGFQPNIFWKVCWAFVTPTILTFI 694

  Fly   562 LVSSVVFMVIRNPTYGAWNADLGMIEQKSYPNWVMGIALSMILAGVLPMPIVFLMRSF 619
            |..|  |......|||::.          ||||.|.:...|:...|:.:||:|:::.:
  Rat   695 LCFS--FYQWEPMTYGSYR----------YPNWSMVLGWLMLACSVIWIPIMFVIKMY 740

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43066	NP_001246408.1	SLC6sbd-B0AT-like	55..617	CDD:271364	226/606 (37%)
Slc6a5	NP_976079.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..64
		SLC6sbd_GlyT2	193..789	CDD:271389	226/610 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810