Protein Alignment CG43066 and Slc6a12

DIOPT Version :10

• Sequence 1: NP_001246408.1
• Gene: CG43066 / 37129
• FlyBaseID: FBgn0262476
• Length: 721
• Species: Drosophila melanogaster
• Sequence 2: NP_598422.2
• Gene: Slc6a12 / 14411
• MGIID: 95628
• Length: 628
• Species: Mus musculus
• Alignment Length: 688
• Identity: 219/688 - (31%)
• Similarity: 347/688 - (50%)
• Gaps: 110/688 - (15%)

  Fly    11 RNGHEMAPLNTRARGDGTH--GVTIVLTAPQRNSVQSVDIPGNE--PERAAWSGKMQFFLSIIGY 71
            |...|.|.|::..|....|  |..:|...|:..  :.:|..|.:  .:|..|:.||:|.||:.|.
Mouse     4 RAWEERASLSSMDRKVAVHEDGYPVVSWVPEEG--EMMDQKGKDQVKDRGQWTNKMEFVLSVAGE 66

  Fly    72 SVGLGNIWRFPYLCQQNGGGAFLIPFMVMLILEGIPLFLIELGIGQRMRLGALGVWNTIHPWLGG 136
            .:||||:|||||||.:||||||.||:.:.....|||:|.:|:.:||....|::..|..|.|.|.|
Mouse    67 IIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFSCGIPVFFLEVALGQYSSQGSVTAWRKICPLLQG 131

  Fly   137 IGISSCIVTLFVALYYNVIITWVFFYLFNSFRYPLPWSSCPLNGTGFELEEC-----------AK 190
            ||::|.::..::.:||.:|:.|..||||:||.:.|||::|.   ..:..|.|           ..
Mouse   132 IGMASVVIESYLNIYYIIILAWALFYLFSSFTWELPWTTCT---NSWNTEHCVDFLNHSSARGVS 193

  Fly   191 SSE-----TTYFWYRTTLDAAPSMDEPGGLKWWIVLCLMLSWTIVFFIVMKGIQSSGKVVYFTSL 250
            |||     ...||.|..|.....:.:.|.|:|.:.|||:|:|.|.:|.:.||::|:|||||||:.
Mouse   194 SSENFTSPVMEFWERRVLGITSGIHDLGSLRWELALCLLLAWIICYFCIWKGVKSTGKVVYFTAT 258

  Fly   251 FPYIVLTIFFIRGITLRGAGAGLMHMYTPKVEKLLEPTVWLDAATQVFYSFGLAFGSLIAFGSYN 315
            |||::|.|..|||:||.||..|::....|.:.:|.:|.||:||.||:|:||.:..|.|.|.||||
Mouse   259 FPYLMLIILLIRGVTLPGAYQGIVFYLKPDLLRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYN 323

  Fly   316 TPKNNCVRDVLLVSVCNAVTAIYASVVIFAILGFKATVNVDRCVASNTEILVKNKLLGLNDTQGY 380
            ...|||.||.:.:...|:.|:..|..|:|:||||                        ::..||
Mouse   324 KYHNNCYRDSIALCFLNSATSFVAGFVVFSILGF------------------------MSQEQG- 363

  Fly   381 EQAMSLLNGTELLRLQLSECSLAHELDNAAEGTGLAFIVFTQAIVELPGAPFWAVLFFTMLLSLG 445
                          :.:||.        |..|.|||||.|.:|:..:|.:..|:.|||.|||.||
Mouse   364 --------------IPISEV--------AESGPGLAFIAFPKAVTMMPLSQLWSCLFFIMLLFLG 406

  Fly   446 LGSQIGILEGMLCTLFDI---DIIKRVKKQHVTGVVCLFCFIVGFIFCTGAGEYWLKMFDSFAGT 507
            |.||...:|.::....|:   .:.|..:::.:...:.:.|:::|.:..|..|.|..::||.:|.:
Mouse   407 LDSQFVCMECLVTASMDMFPQQLRKSGRRELLILAISVLCYLMGLLLVTEGGMYIFQLFDYYASS 471

  Fly   508 -IGLVVVALMEMIAVIFIYGHERFTEDIFQMTGYRPGRYWQWTWRYIGPVIMVCILVSSVVFMVI 571
             |.|:.::|.|:|.:.::||.:||.:::..|.||||....:.:|.::.|.:  |:   :..|..:
Mouse   472 GICLLFLSLFEVICIGWVYGADRFYDNVEDMIGYRPWPLVKISWLFLTPGL--CL---ATFFFSL 531

  Fly   572 RNPTYGAWNADLGMIEQKSYPNWVMGIALSMILAGVLPMPIVFLMRSFQCLKVDLDIHQGSIRRN 636
            ...|...:|      ....||:|...|...:..:.:..:|: |::.:|  ||.     |||.::.
Mouse   532 SKYTPLKYN------NVYMYPSWGYSIGWLLAFSSMACVPL-FIIITF--LKT-----QGSFKKR 582

  Fly   637 ETTASTKEMIDND----------DDDDEDDENDFSGPA 664
                 .:.:|..|          ..|....:|..|.||
Mouse   583 -----LRRLITPDPSLPQPGRRPPQDGSSAQNCSSSPA 615

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43066	NP_001246408.1	SLC6sbd-B0AT-like	55..617	CDD:271364	195/581 (34%)
Slc6a12	NP_598422.2	SLC5-6-like_sbd	49..589	CDD:444915	202/613 (33%)