Protein Alignment CG43066 and Slc6a3

DIOPT Version :10

• Sequence 1: NP_001246408.1
• Gene: CG43066 / 37129
• FlyBaseID: FBgn0262476
• Length: 721
• Species: Drosophila melanogaster
• Sequence 2: NP_034150.1
• Gene: Slc6a3 / 13162
• MGIID: 94862
• Length: 619
• Species: Mus musculus
• Alignment Length: 656
• Identity: 217/656 - (33%)
• Similarity: 332/656 - (50%)
• Gaps: 105/656 - (16%)

  Fly    27 GTHGVTIVLTAPQRNSVQSVD--------IPGNEPERAAWSGKMQFFLSIIGYSVGLGNIWRFPY 83
            |...|.::|...| |.||..:        .|....||..||.|:.|.||:||::|.|.|:|||||
Mouse    25 GPREVELILVKEQ-NGVQLTNSTLINPPQTPVEVQERETWSKKIDFLLSVIGFAVDLANVWRFPY 88

  Fly    84 LCQQNGGGAFLIPFMVMLILEGIPLFLIELGIGQRMRLGALGVWNTIHPWLGGIGISSCIVTLFV 148
            ||.:|||||||:|:::.:::.|:|||.:||.:||..|.||.|||. |.|.|.|:|.:..:::.:|
Mouse    89 LCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWK-ICPVLKGVGFTVILISFYV 152

  Fly   149 ALYYNVIITWVFFYLFNSFRYPLPWSSCPLNGT----------------GFELEECAKSSETTYF 197
            ..:|||||.|...|.|:||...|||..|  |.|                |..|.:...::....:
Mouse   153 GFFYNVIIAWALHYFFSSFTMDLPWIHC--NNTWNSPNCSDAHSSNSSDGLGLNDTFGTTPAAEY 215

  Fly   198 WYRTTLDAAPS--MDEPGGLKWWIVLCLMLSWTIVFFIVMKGIQSSGKVVYFTSLFPYIVLTIFF 260
            :.|..|....|  :|:.|..:|.:..||:|...:::|.:.||:::|||||:.|:..||:|||...
Mouse   216 FERGVLHLHQSRGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALL 280

  Fly   261 IRGITLRGAGAGLMHMYTPKVEKLLEPTVWLDAATQVFYSFGLAFGSLIAFGSYNTPKNNCVRDV 325
            :||:||.||..|:....:....:|.|.:||:||||||.:|.|:.||.||||.|||...|||.||.
Mouse   281 LRGVTLPGAMDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDA 345

  Fly   326 LLVSVCNAVTAIYASVVIFAILGFKATVNVDRCVASNTEILVKNKLLGLNDTQGYEQAMSLLNGT 390
            ::.:..|::|:..:..|:|:.||:.|..:       |..|
Mouse   346 IITTSINSLTSFSSGFVVFSFLGYMAQKH-------NVPI------------------------- 378

  Fly   391 ELLRLQLSECSLAHELDNAAEGTGLAFIVFTQAIVELPGAPFWAVLFFTMLLSLGLGSQIGILEG 455
                           .|.|.:|.||.||::.:||..||.:..||.:||.|||:||:.|.:|.:|.
Mouse   379 ---------------RDVATDGPGLIFIIYPEAIATLPLSSAWAAVFFLMLLTLGIDSAMGGMES 428

  Fly   456 MLCTLFD-IDIIKRVKKQHVTGVVCLFCFIVGFIFCTGAGEYWLKMFDSFAGTIGLVVVALMEMI 519
            ::..|.| ..::.|.::....|:| |..|::.....|..|.|...:.|.||....::...|:|.|
Mouse   429 VITGLVDEFQLLHRHRELFTLGIV-LATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAI 492

  Fly   520 AVIFIYGHERFTEDIFQMTGYRPGRYWQWTWRYIGPVIMVCILVSSVVFMVIRNPTYGAWNADLG 584
            .|.:.||.::|::||.||||.||..||:..|:.:.|..::.::|.|:|  ..|.|.|||:
Mouse   493 GVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIV--TFRPPHYGAY----- 550

  Fly   585 MIEQKSYPNWVMGIALSMILA-GVLPMPIVFLMRSFQCLKVDLDIHQGSIRRNETTAST----KE 644
                 .:|:|..  ||..|:| ..:.|..::....|..|       .||.|.....|.|    ::
Mouse   551 -----IFPDWAN--ALGWIIATSSMAMVPIYATYKFCSL-------PGSFREKLAYAITPEKDRQ 601

  Fly   645 MIDNDD 650
            ::|..:
Mouse   602 LVDRGE 607

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43066	NP_001246408.1	SLC6sbd-B0AT-like	55..617	CDD:271364	200/581 (34%)
Slc6a3	NP_034150.1	SLC5-6-like_sbd	60..613	CDD:444915	208/620 (34%)
		Interaction with TGFB1I1. /evidence=ECO:0000250	560..589		8/35 (23%)