Protein Alignment CG43066 and DAT

DIOPT Version :10

• Sequence 1: NP_001246408.1
• Gene: CG43066 / 37129
• FlyBaseID: FBgn0262476
• Length: 721
• Species: Drosophila melanogaster
• Sequence 2: XP_061499264.1
• Gene: DAT / 1269812
• VectorBaseID: AGAMI1_006978
• Length: 678
• Species: Anopheles gambiae
• Alignment Length: 699
• Identity: 233/699 - (33%)
• Similarity: 339/699 - (48%)
• Gaps: 144/699 - (20%)

  Fly     5 KIIDAPRNGHE------MAPLNTRAR---GDGTHGVTIVLTAPQRNSVQSVDIPGNEP------- 53
            |..|:.::|.:      :..||..|.   |..:.|..:.:|.  ...:::...||..|
Mosquito    19 KCTDSSKSGSDSIEGDALKELNGGAENGVGGDSEGTALAMTT--IGQIKAKGRPGLLPRNGAGGG 81

  Fly    54 ------------ERAAWSGKMQFFLSIIGYSVGLGNIWRFPYLCQQNGGGAFLIPFMVMLILEGI 106
                        ||..||||:.|.||:||::|.|.|:|||||||.:|||||||||:.:||::.||
Mosquito    82 GGGGGGELDDGEERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLIPYGIMLVVGGI 146

  Fly   107 PLFLIELGIGQRMRLGALGVWNTIHPWLGGIGISSCIVTLFVALYYNVIITWVFFYLFNSFRYPL 171
            |||.:||.:||..|.||:..|..:.|...|||.:..::..:|..||||||.|...:.|.||...|
Mosquito   147 PLFYMELALGQFNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFFASFTDSL 211

  Fly   172 PWSSC--------------------------------------PLNGTGFELEECAKSSETTYF- 197
            ||:.|                                      .:|.|.|      .|:.:.||
Mosquito   212 PWTHCSNAWNTVECKPFGYINSTAATVVNRTGVLAANVTGTVSTINDTKF------ASAASEYFN 270

  Fly   198 WYRTTLDAAPSMDEPGGLKWWIVLCLMLSWTIVFFIVMKGIQSSGKVVYFTSLFPYIVLTIFFIR 262
            .|...||.:..:.:.|.:||.:.|||:..:.|.:|.:.|||.:|||||:||:||||.||.|..:|
Mosquito   271 RYILELDKSEGIHDLGAIKWDMALCLLAVYLICYFSLWKGISTSGKVVWFTALFPYAVLLILLVR 335

  Fly   263 GITLRGAGAGLMHMYTPKVEKLLEPTVWLDAATQVFYSFGLAFGSLIAFGSYNTPKNNCVRDVLL 327
            ||||.|:..|:::...|..:.:....||:|||||||:|.|..||.|:|:.|||...||..:|.||
Mosquito   336 GITLPGSAEGILYYLRPNFDVIYNAEVWVDAATQVFFSLGPGFGVLLAYASYNKYHNNVYKDALL 400

  Fly   328 VSVCNAVTAIYASVVIFAILGFKATVNVDRCVASNTEILVKNKLLGLNDTQGYEQAMSLLNGTEL 392
            .|:.|:.|:..|..|||::||:.|.       ||...|
Mosquito   401 TSLINSATSFIAGFVIFSVLGYMAH-------ASGQSI--------------------------- 431

  Fly   393 LRLQLSECSLAHELDNAAEGTGLAFIVFTQAIVELPGAPFWAVLFFTMLLSLGLGSQIGILEGML 457
                         .|.|.||.||.|:|:..||..:||:.|||::||.|||:|||.|..|..|.::
Mosquito   432 -------------QDVATEGPGLVFVVYPAAIATMPGSIFWALIFFMMLLTLGLDSSFGGSEAII 483

  Fly   458 CTLFD-IDIIKRVKKQHVTGVVCLFCFIVGFIFCTGAGEYWLKMFDSFAGTIGLVVVALMEMIAV 521
            ..|.| ...|.|.::..|..:..|: |:||...||..|.|:.::.|.:|....:::....|.|||
Mosquito   484 TALSDEFPKIGRNREIFVAVLFSLY-FVVGLASCTQGGFYFFQLLDRYAAGYSILIAVFFEAIAV 547

  Fly   522 IFIYGHERFTEDIFQMTGYRPGRYWQWTWRYIGPVIMVCILVSSVVFMVIRNPTYGAWNADLGMI 586
            .:|||.|||..||..|.|:.||.||:..|:::.|:.::.|::            ||....:....
Mosquito   548 SWIYGTERFCNDIKDMIGFAPGIYWRVCWKFVAPLFLLFIII------------YGLIGHEPLSY 600

  Fly   587 EQKSYPNWVMGIALSMILAGVLPMPIVFLMRSFQCLKVDLDIHQGSIRR 635
            |...||:|..  .|...:|| ..|.::.||.|::     |.:..||:|:
Mosquito   601 EDYVYPSWAN--VLGWCIAG-SSMIMIPLMASYK-----LIVTPGSLRQ 641

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43066	NP_001246408.1	SLC6sbd-B0AT-like	55..617	CDD:271364	214/601 (36%)
DAT	XP_061499264.1	None