Protein Alignment CG43066 and Slc6a7

DIOPT Version :10

• Sequence 1: NP_001246408.1
• Gene: CG43066 / 37129
• FlyBaseID: FBgn0262476
• Length: 721
• Species: Drosophila melanogaster
• Sequence 2: NP_446448.2
• Gene: Slc6a7 / 117100
• RGDID: 620928
• Length: 637
• Species: Rattus norvegicus
• Alignment Length: 691
• Identity: 238/691 - (34%)
• Similarity: 349/691 - (50%)
• Gaps: 133/691 - (19%)

  Fly    33 IVLTAPQRNSVQ-SVDIPGNEPERAAWSGKMQFFLSIIGYSVGLGNIWRFPYLCQQNGGGAFLIP 96
            :::|...:..|. .||...   :|..|:||:.|.||.|||.|||||:|||||....|||||||:|
  Rat    17 LLMTPSDQGDVDLDVDFAA---DRGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGAFLVP 78

  Fly    97 FMVMLILEGIPLFLIELGIGQRMRLGALGVWNTIHPWLGGIGISSCIVTLFVALYYNVIITWVFF 161
            :.:||.:.|||||.:||.:||...||.|.||. |.|...|.|.:..::...||:|||:||.:|.|
  Rat    79 YFLMLAICGIPLFFLELSLGQFSSLGPLAVWK-ISPLFKGAGAAMLLIVGLVAIYYNMIIAYVLF 142

  Fly   162 YLFNSFRYPLPWSSC--------------PLNGTG---FELEECAKSSETTYFWYRTTLDAAPSM 209
            |||.|....|||..|              |.:|.|   ..|......||..:..|...:..:..:
  Rat   143 YLFASLTSNLPWEHCGNWWNTERCLEHRGPKDGNGALPLNLSSTVSPSEEYWSRYVLHIQGSQGI 207

  Fly   210 DEPGGLKWWIVLCLMLSWTIVFFIVMKGIQSSGKVVYFTSLFPYIVLTIFFIRGITLRGAGAGLM 274
            ..||.::|.:.|||:|:|.|||..::||::|||||||||:.|||::|.:..:||:||.||..|:.
  Rat   208 GRPGEIRWNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLILLMLLVRGVTLPGAWKGIQ 272

  Fly   275 HMYTPKVEKLLEPTVWLDAATQVFYSFGLAFGSLIAFGSYNTPKNNCVRDVLLVSVCNAVTAIYA 339
            ...||:...||...||::||.|:|||.|:.||.|:.|.||||...|..||..:|::.||:|:|.|
  Rat   273 FYLTPQFHHLLSSKVWIEAALQIFYSLGVGFGGLLTFASYNTFHQNIYRDTFIVTLGNAITSILA 337

  Fly   340 SVVIFAILGFKAT---VNVDRCVASNTEILVKNKLLGLNDTQGYEQAMSLLNGTELLRLQLSECS 401
            ...||::||:.:.   |.||:.
  Rat   338 GFAIFSVLGYMSQELGVPVDQV------------------------------------------- 359

  Fly   402 LAHELDNAAEGTGLAFIVFTQAIVELPGAPFWAVLFFTMLLSLGLGSQIGILEGMLCTLFD-IDI 465
                   |..|.||||:|:.||:..||.:|||:.|||.|||:|||.||...||.::..:.| ...
  Rat   360 -------AKAGPGLAFVVYPQAMTMLPLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDEFPY 417

  Fly   466 IKRVKKQHVTGVVCLFCFIVGFIFCTGAGEYWLKMFDSFAGTIGLVVVALMEMIAVIFIYGHERF 530
            ..|.||...:|::|:..:::|.|..|..|.|||.:.|.::.:.||:||.:...:||..:||.:||
  Rat   418 YLRPKKAVFSGLICVAMYLMGLILTTDGGMYWLVLLDDYSASFGLMVVVITTCLAVTRVYGIQRF 482

  Fly   531 TEDIFQMTGYRPGRYWQWTWRYIGPVIMVCILVSSVVFMVIRNPTYGAWNADLGMIEQKSYPNW- 594
            ..||..|.|::||.|::..|.::.|..::.:||.|:|  ..:...||::.          :|.|
  Rat   483 CRDIHMMLGFKPGLYFRACWLFLSPATLLALLVYSIV--KYQPSEYGSYR----------FPAWA 535

  Fly   595 -VMGIALS-----MILAGVLPMPIVFLMRSFQCLKVDLDIHQGSIRRNETTASTKEMIDNDDDDD 653
             ::||.:.     ||.||:|    |.::|           .:||:......|| :..||
  Rat   536 ELLGILMGLLSCLMIPAGML----VAVLR-----------EEGSLWERLQQAS-RPAID------ 578

  Fly   654 EDDENDFSGPAL-----GGHVKTQSDFSDDDEEDKPMTMRM 689
                   .||:|     |.:|.|.:    ..:..||:.:.|
  Rat   579 -------WGPSLEENRTGMYVATLA----GSQSPKPLMVHM 608

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43066	NP_001246408.1	SLC6sbd-B0AT-like	55..617	CDD:271364	218/589 (37%)
Slc6a7	NP_446448.2	SLC5-6-like_sbd	37..581	CDD:444915	225/635 (35%)