DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43066 and Slc6a20

DIOPT Version :9

Sequence 1:	NP_001246408.1	Gene:	CG43066 / 37129	FlyBaseID:	FBgn0262476	Length:	721	Species:	Drosophila melanogaster
Sequence 2:	NP_579830.1	Gene:	Slc6a20 / 113918	RGDID:	621651	Length:	616	Species:	Rattus norvegicus

Alignment Length:	590	Identity:	258/590 - (43%)
Similarity:	383/590 - (64%)	Gaps:	28/590 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 PGNEPERA--------AWSGKMQFFLSIIGYSVGLGNIWRFPYLCQQNGGGAFLIPFMVMLILEG 105
            ||.:.:||        .|...:||..:.|.|:|||||:||||||||..|||:||:|:::|||:||
  Rat    15 PGPDEKRARDMEKARPQWGNPLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYLIMLIVEG 79

  Fly   106 IPLFLIELGIGQRMRLGALGVWNTIHPWLGGIGISSCIVTLFVALYYNVIITWVFFYLFNSFRYP 170
            :||..:||.:|||||.|::|.|.||.|:|.|:|::|.:|:.|:::|||||..|.|:|||:||:.|
  Rat    80 MPLLYLELAVGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWGFWYLFHSFQDP 144

  Fly   171 LPWSSCPLNG--TGFELEECAKSSETTYFWYRTTLDAAPSMDEPGGLKWWIVLCLMLSWTIVFFI 233
            ||||.||||.  ||:: |||.|:|.|.|||||.||:.:||:.|.||::|...|||.|:|.:|:..
  Rat   145 LPWSVCPLNSNRTGYD-EECEKASSTQYFWYRKTLNISPSIQENGGVQWEPALCLTLAWLMVYLC 208

  Fly   234 VMKGIQSSGKVVYFTSLFPYIVLTIFFIRGITLRGAGAGLMHMYTPKVEKLLEPTVWLDAATQVF 298
            :::|.:|:|||||||:|.||.||.|:.:||:||.||..|||:|:|||:|:|..|..|::||||:|
  Rat   209 ILRGTESTGKVVYFTALMPYCVLIIYLVRGLTLHGATNGLMYMFTPKIEQLANPKAWINAATQIF 273

  Fly   299 YSFGLAFGSLIAFGSYNTPKNNCVRDVLLVSVCNAVTAIYASVVIFAILGFKATVNVDRCVASNT 363
            :|.||.|||||||.|||.|.|:|.:..::|||.|:.|:|:||:|.|:|.|||||.|.:.|:  |.
  Rat   274 FSLGLGFGSLIAFASYNEPSNDCQKHAVIVSVINSSTSIFASIVTFSIYGFKATFNYENCL--NK 336

  Fly   364 EILVKNKLLGLNDTQGYEQAMSLLNGTELLRL-----------QLSECSLAHELDNAAEGTGLAF 417
            .||:......|.|  |:..|.:|....:.|..           .:..|||..||:.|.:||||||
  Rat   337 VILLLTNSFDLED--GFLTASNLEEVKDYLASTYPNKYSEVFPHIRNCSLESELNTAVQGTGLAF 399

  Fly   418 IVFTQAIVELPGAPFWAVLFFTMLLSLGLGSQIGILEGMLCTLFDIDIIKR-VKKQHVTGVVCLF 481
            ||:.:||..:..:..|:||:|.|||.||:||.:|....:|..|.|..:|.. :.|:.::|:|||.
  Rat   400 IVYAEAIKNMEVSQLWSVLYFFMLLMLGMGSMLGNTAAILTPLTDSKVISSYLPKEAISGLVCLI 464

  Fly   482 CFIVGFIFCTGAGEYWLKMFDSFAGTIGLVVVALMEMIAVIFIYGHERFTEDIFQMTGYRPGRYW 546
            ...||.:|...||.||..:|:.:|.|:.|:::.|:|.|||.::||..||..|:..|||.....||
  Rat   465 NCAVGMVFTMEAGNYWFDIFNDYAATLSLLLIVLVETIAVCYVYGLRRFESDLRAMTGRPLNWYW 529

  Fly   547 QWTWRYIGPVIMVCILVSSVV-FMVIRNPTYGAWNADLGMIEQKSYPNWVMGIALSMILAGVLPM 610
            :..|.::.|::::.:.:..:. :::.....|.||:|..|.:..|.||...:.:...::.:..:.:
  Rat   530 KAMWAFVSPLLIIGLFIFYLSDYILTGTLQYQAWDATQGQLVTKDYPPHALAVIGLLVASSTMCI 594

  Fly   611 PIVFL 615
            |:|.|
  Rat   595 PLVAL 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43066	NP_001246408.1	SLC6sbd-B0AT-like	55..617	CDD:271364	256/584 (44%)
Slc6a20	NP_579830.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26		4/10 (40%)
Slc6a20	NP_579830.1	SLC5-6-like_sbd	26..601	CDD:294310	254/579 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48419
OrthoDB	1	1.010	-	-		D251682at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.890