DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43066 and SLC6A14

DIOPT Version :9

Sequence 1:	NP_001246408.1	Gene:	CG43066 / 37129	FlyBaseID:	FBgn0262476	Length:	721	Species:	Drosophila melanogaster
Sequence 2:	NP_009162.1	Gene:	SLC6A14 / 11254	HGNCID:	11047	Length:	642	Species:	Homo sapiens

Alignment Length:	687	Identity:	231/687 - (33%)
Similarity:	345/687 - (50%)	Gaps:	147/687 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 ERAAWSGKMQFFLSIIGYSVGLGNIWRFPYLCQQNGGGAFLIPFMVMLILEGIPLFLIELGIGQR 118
            :|..||.|..:.||:|||:|||||:||||||...|||||||||:.:||.|.|:|||.:|..:||.
Human    35 DRGNWSKKSDYLLSMIGYAVGLGNVWRFPYLTYSNGGGAFLIPYAIMLALAGLPLFFLECSLGQF 99

  Fly   119 MRLGALGVWNTIHPWLGGIGISSCIVTLFVALYYNVIITWVFFYLFNSFRYPLPWSSCPLNGTGF 183
            ..||.:.||. |.|...|:||:..::::||.:||||||.:..:|:|.||:..|||.:|    :.:
Human   100 ASLGPVSVWR-ILPLFQGVGITMVLISIFVTIYYNVIIAYSLYYMFASFQSELPWKNC----SSW 159

  Fly   184 ELEECAKSSETTY--------------------------------------------FWYRTTLD 204
            ..:.|::|...|:                                            :|.:..|.
Human   160 SDKNCSRSPIVTHCNVSTVNKGIQEIIQMNKSWVDINNFTCINGSEIYQPGQLPSEQYWNKVALQ 224

  Fly   205 AAPSMDEPGGLKWWIVLCLMLSWTIVFFIVMKGIQSSGKVVYFTSLFPYIVLTIFFIRGITLRGA 269
            .:..|:|.|.:.|::.|||:|:|.||...:.|||:|||||||||:||||:||.|..:||.||.||
Human   225 RSSGMNETGVIVWYLALCLLLAWLIVGAALFKGIKSSGKVVYFTALFPYVVLLILLVRGATLEGA 289

  Fly   270 GAGLMHMY--TPKVEKLLEPTVWLDAATQVFYSFGLAFGSLIAFGSYNTPKNNCVRDVLLVSVCN 332
            ..|:.:..  .....||.|..||.|||||:|||..:|:|.|:|..|||..||||..|.::|.:.|
Human   290 SKGISYYIGAQSNFTKLKEAEVWKDAATQIFYSLSVAWGGLVALSSYNKFKNNCFSDAIVVCLTN 354

  Fly   333 AVTAIYASVVIFAILGFKATVNVDRCVASNTEILVKNKLLGLNDTQGYEQAMSLLNGTELLRLQL 397
            .:|:::|...||:|||.                                  |:.::|.|:.::..
Human   355 CLTSVFAGFAIFSILGH----------------------------------MAHISGKEVSQVVK 385

  Fly   398 SECSLAHELDNAAEGTGLAFIVFTQAIVELPGAPFWAVLFFTMLLSLGLGSQIGILEGMLCTLFD 462
            |             |..||||.:.:|:.:|||.|||::|||.|||:|||.||...:|.:..|:.|
Human   386 S-------------GFDLAFIAYPEALAQLPGGPFWSILFFFMLLTLGLDSQFASIETITTTIQD 437

  Fly   463 IDIIKRVKKQHV--TGVVCLFCFIVGFIFCTGAGEYWLKMFDSFAGTIGLVVVALMEMIAVIFIY 525
            : ..|.:||..|  |...||..|::|.:..|.||.||:.:.|.|....|:::.|::|::.:|:||
Human   438 L-FPKVMKKMRVPITLGCCLVLFLLGLVCVTQAGIYWVHLIDHFCAGWGILIAAILELVGIIWIY 501

  Fly   526 GHERFTEDIFQMTGYRPGRYWQW---TWRYIGPVIMVCILVSSVVFMVIRNPTYGAWNADLGMIE 587
            |..||.||...|.|.:...:|.|   .|..|.|::::.|.:.|:|  ....|.|||
Human   502 GGNRFIEDTEMMIGAKRWIFWLWWRACWFVITPILLIAIFIWSLV--QFHRPNYGA--------- 555

  Fly   588 QKSYPNWVMGIALSMILAGVLPMPIVFLMRSFQ------------CLKVD-----LDIHQGSIRR 635
             ..||:|.:.:...||:..::.:||:.:::..|            |....     |:.|:|.
Human   556 -IPYPDWGVALGWCMIVFCIIWIPIMAIIKIIQAKGNIFQRLISCCRPASNWGPYLEQHRGE--- 616

  Fly   636 NETTASTKEMIDNDDDDDEDDENDFSGPALGGHVKTQ 672
                 ..|:|:      |...|.|...|.:.|..|.:
Human   617 -----RYKDMV------DPKKEADHEIPTVSGSRKPE 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43066	NP_001246408.1	SLC6sbd-B0AT-like	55..617	CDD:271364	218/612 (36%)
SLC6A14	NP_009162.1	SLC6sbd_ATB0	36..641	CDD:271391	230/683 (34%)
SLC6A14	NP_009162.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	622..642		6/25 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810