Protein Alignment CG43066 and Slc6a5

DIOPT Version :10

• Sequence 1: NP_001246408.1
• Gene: CG43066 / 37129
• FlyBaseID: FBgn0262476
• Length: 721
• Species: Drosophila melanogaster
• Sequence 2: XP_006540608.1
• Gene: Slc6a5 / 104245
• MGIID: 105090
• Length: 831
• Species: Mus musculus
• Alignment Length: 643
• Identity: 237/643 - (36%)
• Similarity: 346/643 - (53%)
• Gaps: 116/643 - (18%)

  Fly    27 GTHGVTIVLTAPQRNSVQSVDIPGNE-----PERAAWSGKMQFFLSIIGYSVGLGNIWRFPYLCQ 86
            ||.|:..||.    .||.:..||.:|     ..|..||.|:.|.||::||:|||||:||||||..
Mouse   196 GTDGIASVLP----GSVATTTIPEDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAF 256

  Fly    87 QNGGGAFLIPFMVMLILEGIPLFLIELGIGQRMRLGALGVWNTIHPWLGGIGISSCIVTLFVALY 151
            ||||||||||:::||.|.|:|:|.:|:.:||....|.:.||..| |.|.|.||:..|:::.:|:|
Mouse   257 QNGGGAFLIPYLMMLALAGLPIFFLEVSLGQFASQGPVSVWKAI-PALQGCGIAMLIISVLIAIY 320

  Fly   152 YNVIITWVFFYLFNSFRYPLPWSSC--PLN------GTGFELEECA------------------- 189
            |||||.:..||||.||...|||.||  |.|      .|...|:.|.
Mouse   321 YNVIICYTLFYLFASFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVIGDHPKIQIKNSTFCMTAY 385

  Fly   190 ----------------KSSETTYFWYRTTLDAAPSMDEPGGLKWWIVLCLMLSWTIVFFIVMKGI 238
                            .|....||.| ..|..:..::.||.::|.:..||.|:|.||:..:.|||
Mouse   386 PNLTMVNFTSQTNKTFVSGSEEYFKY-FVLKISAGIEYPGEIRWPLAFCLFLAWVIVYASLAKGI 449

  Fly   239 QSSGKVVYFTSLFPYIVLTIFFIRGITLRGAGAGLMHMYTPKVEKLLEPTVWLDAATQVFYSFGL 303
            :|||||||||:.|||:||.|..|||:||.|||||:.:..|||.|||.:.|||.|||||:|:|...
Mouse   450 KSSGKVVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSA 514

  Fly   304 AFGSLIAFGSYNTPKNNCVRDVLLVSVCNAVTAIYASVVIFAILGFKATVNVDRCVASNTEILVK 368
            |:|.||...|||...|||.||.|:|:..|:.|:|:|..|||:::||         :|:..::.::
Mouse   515 AWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGF---------MANERKVNIE 570

  Fly   369 NKLLGLNDTQGYEQAMSLLNGTELLRLQLSECSLAHELDNAAEGTGLAFIVFTQAIVELPGAPFW 433
            |.                                      |.:|.|:||:|:.:|:..||.:|||
Mouse   571 NV--------------------------------------ADQGPGIAFVVYPEALTRLPLSPFW 597

  Fly   434 AVLFFTMLLSLGLGSQIGILEGMLCTLFDIDIIK--RVKKQHVTGVVCLFCFIVGFIFCTGAGEY 496
            |::||.|||:|||.:....:|.::.::.| :..|  |..|...|...|:..||:||...|..|.|
Mouse   598 AIIFFLMLLTLGLDTMFATIETIVTSISD-EFPKYLRTHKPVFTLGCCICFFIMGFPMITQGGIY 661

  Fly   497 WLKMFDSFAGTIGLVVVALMEMIAVIFIYGHERFTEDIFQMTGYRPGRYWQWTWRYIGPVIMVCI 561
            ..::.|::|.:..||::|:.|::.:.::||.:||.|||..|.|::|..:|:..|.::.|.|:..|
Mouse   662 MFQLVDTYAASYALVIIAIFELVGISYVYGLQRFCEDIEMMIGFKPNIFWKVCWAFVTPTILTFI 726

  Fly   562 LVSSVVFMVIRNPTYGAWNADLGMIEQKSYPNWVMGIALSMILAGVLPMPIVFLMRSF 619
            |..|  |......|||::.          ||||.|.:...|:...|:.:||:|:::.:
Mouse   727 LCFS--FYQWEPMTYGSYR----------YPNWSMVLGWLMLACSVIWIPIMFVIKMY 772

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43066	NP_001246408.1	SLC6sbd-B0AT-like	55..617	CDD:271364	227/606 (37%)
Slc6a5	XP_006540608.1	SLC6sbd_GlyT2	225..821	CDD:271389	227/610 (37%)