DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43066 and Slc6a20a

DIOPT Version :9

Sequence 1:	NP_001246408.1	Gene:	CG43066 / 37129	FlyBaseID:	FBgn0262476	Length:	721	Species:	Drosophila melanogaster
Sequence 2:	NP_631881.1	Gene:	Slc6a20a / 102680	MGIID:	2143217	Length:	592	Species:	Mus musculus

Alignment Length:	578	Identity:	258/578 - (44%)
Similarity:	380/578 - (65%)	Gaps:	18/578 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 EPERAAWSGKMQFFLSIIGYSVGLGNIWRFPYLCQQNGGGAFLIPFMVMLILEGIPLFLIELGIG 116
            |..|..|...:||..:.|.|:|||||:||||||||..|||:||:|:::|||:||:||..:||.:|
Mouse     2 EKARPQWGHPLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELAVG 66

  Fly   117 QRMRLGALGVWNTIHPWLGGIGISSCIVTLFVALYYNVIITWVFFYLFNSFRYPLPWSSCPLNG- 180
            ||||.|::|.|.||.|:|.|:|::|.:|:.|:::|||||..|.|:|||:||:.|||||.||||.
Mouse    67 QRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWGFWYLFHSFQDPLPWSVCPLNSN 131

  Fly   181 -TGFELEECAKSSETTYFWYRTTLDAAPSMDEPGGLKWWIVLCLMLSWTIVFFIVMKGIQSSGKV 244
             ||:: |||.|:|.|.|||||.||:.:||:.|.||::|...|||.|:|.:|:..:::|.:|:|||
Mouse   132 HTGYD-EECEKASSTQYFWYRKTLNISPSIQENGGVQWEPALCLTLAWLMVYLCILRGTESTGKV 195

  Fly   245 VYFTSLFPYIVLTIFFIRGITLRGAGAGLMHMYTPKVEKLLEPTVWLDAATQVFYSFGLAFGSLI 309
            ||||:..||.||.|:.:||:||.||..|||:|:|||:|:|..|..|::||||:|:|.||.|||||
Mouse   196 VYFTASMPYCVLIIYLVRGLTLHGATNGLMYMFTPKMEQLANPKAWINAATQIFFSLGLGFGSLI 260

  Fly   310 AFGSYNTPKNNCVRDVLLVSVCNAVTAIYASVVIFAILGFKATVNVDRCVASNTEILVKNKLLGL 374
            ||.|||.|.|||.:..::||:.|:.|:|:||:|.|:|.|||||.|.:.|:  |..||:......|
Mouse   261 AFASYNEPSNNCQKHAIIVSIINSSTSIFASIVTFSIYGFKATFNYENCL--NKVILLLTNSFDL 323

  Fly   375 ND----TQGYEQAMSLLNGT------ELLRLQLSECSLAHELDNAAEGTGLAFIVFTQAIVELPG 429
            .|    ....|:..:.|..|      |:.. .:..|||..|||.|.:||||||||:|:||..:..
Mouse   324 EDGFLTVSNLEEVKNYLASTYPNKYSEVFP-HIRNCSLESELDTAVQGTGLAFIVYTEAIKNMEV 387

  Fly   430 APFWAVLFFTMLLSLGLGSQIGILEGMLCTLFDIDIIKR-VKKQHVTGVVCLFCFIVGFIFCTGA 493
            :..|:||:|.|||.||:||.:|....:|..|.|..:|.. :.|:.::|:|||....||.:|...|
Mouse   388 SQLWSVLYFFMLLMLGIGSMLGNTAAILTPLTDSKVISSYLPKEAISGLVCLINCAVGMVFTMEA 452

  Fly   494 GEYWLKMFDSFAGTIGLVVVALMEMIAVIFIYGHERFTEDIFQMTGYRPGRYWQWTWRYIGPVIM 558
            |.||..:|:.:|.|:.|:::.|:|.|||.::||.:||..|:..|||.....||:..|.::.|:::
Mouse   453 GNYWFDIFNDYAATLSLLLIVLVETIAVCYVYGLKRFESDLRAMTGRTLSWYWKVMWAFVSPLLI 517

  Fly   559 VCILVSSVV-FMVIRNPTYGAWNADLGMIEQKSYPNWVMGIALSMILAGVLPMPIVFL 615
            |.:.:..:. :::.....|.||:|..|.:..|.||...:.:...::.:..:.:|:|.|
Mouse   518 VGLFIFYLSDYILTGTLQYQAWDATQGQLVTKDYPPHALAVIGLLVASSTMCIPLVAL 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43066	NP_001246408.1	SLC6sbd-B0AT-like	55..617	CDD:271364	257/575 (45%)
Slc6a20a	NP_631881.1	SLC5-6-like_sbd	2..577	CDD:294310	258/578 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4234
OMA	1	1.010	-	-		QHG48419
OrthoDB	1	1.010	-	-		D251682at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.840