Protein Alignment CG43066 and slc6a2

DIOPT Version :10

• Sequence 1: NP_001246408.1
• Gene: CG43066 / 37129
• FlyBaseID: FBgn0262476
• Length: 721
• Species: Drosophila melanogaster
• Sequence 2: XP_017948962.2
• Gene: slc6a2 / 100486589
• XenbaseID: XB-GENE-486549
• Length: 624
• Species: Xenopus tropicalis
• Alignment Length: 675
• Identity: 226/675 - (33%)
• Similarity: 342/675 - (50%)
• Gaps: 133/675 - (19%)

  Fly    25 GDGTHGVTIVLTAPQRNSVQSV------------------------DIPG-NEPERAAWSGKMQF 64
            |...|.::.|  ||::..|:.:                        ::|| .:.||..|..|:.|
 Frog    10 GQSDHKLSAV--APEKKDVELILVKEQNGVQYTSSTVIVPDLSPQYEVPGEGQQEREQWGKKIDF 72

  Fly    65 FLSIIGYSVGLGNIWRFPYLCQQNGGGAFLIPFMVMLILEGIPLFLIELGIGQRMRLGALGVWNT 129
            .||::|:||.|.|:||||:||.:|||||||||:.:.||:.|:|||.:||.:||..|.||..||.
 Frog    73 LLSVVGFSVDLANVWRFPFLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYNREGAATVWK- 136

  Fly   130 IHPWLGGIGISSCIVTLFVALYYNVIITWVFFYLFNSFRYPLPWSSCPLNGTGFELEECAK---- 190
            |.|...|:|.:..::.|:|..||||||.|..:||.:||...|||..|   |..:....|..
 Frog   137 ICPLFKGVGYTVILIALYVGFYYNVIIAWSLYYLVSSFTSELPWIKC---GNEWNSLNCTDPMLL 198

  Fly   191 -----SSETTYFWYRTT------------LDAAPSMDEPGGLKWWIVLCLMLSWTIVFFIVMKGI 238
                 |..|.|..::||            |..:..:.:.|..:|.:.:||::...::||.:.||:
 Frog   199 NMSMISYNTKYSKFKTTPAAEFYERGVLHLHESNGIHDLGQPRWQLTICLIVVLIVLFFSLWKGV 263

  Fly   239 QSSGKVVYFTSLFPYIVLTIFFIRGITLRGAGAGLMHMYTPKVEKLLEPTVWLDAATQVFYSFGL 303
            ::|||||:.|:..||:||.:..||||||.|:..|:.......:::|.:.:||:|||||:|||.|.
 Frog   264 KTSGKVVWITATLPYVVLFVLLIRGITLPGSSKGISAYLHIDIKRLTDASVWIDAATQIFYSLGA 328

  Fly   304 AFGSLIAFGSYNTPKNNCVRDVLLVSVCNAVTAIYASVVIFAILGF---KATVNVDRCVASNTEI 365
            .||.||||.|||...|||.||.|:.|..|.||:..:...||:|||:   |..||::
 Frog   329 GFGVLIAFASYNKFDNNCYRDALMTSTINCVTSFISGFAIFSILGYMAHKHNVNIE--------- 384

  Fly   366 LVKNKLLGLNDTQGYEQAMSLLNGTELLRLQLSECSLAHELDNAAEGTGLAFIVFTQAIVELPGA 430
                                                     |.|.||.||.||::.:||..|.|:
 Frog   385 -----------------------------------------DVATEGAGLVFIIYPEAISTLAGS 408

  Fly   431 PFWAVLFFTMLLSLGLGSQIGILEGMLCTLF-DIDIIKRVKKQHVTGVVCLFCFIVGFIFCTGAG 494
            .||||:||.|||:||:.|.:|.:|.::..|. ||.|:||.:|. .|.:|....||...:..|..|
 Frog   409 TFWAVVFFIMLLTLGIDSAMGGMEAVITGLADDISILKRHRKL-FTLLVAFITFIFALLCITNGG 472

  Fly   495 EYWLKMFDSFAGTIGLVVVALMEMIAVIFIYGHERFTEDIFQMTGYRPGRYWQWTWRYIGPVIMV 559
            .|.|.:.|:||....::...|:|.|.|.:.||.:||:|||.:|.|:|||.||:..|:::.|..::
 Frog   473 IYVLTLLDTFAAGTSILFAVLIEAIGVSWFYGVDRFSEDIHRMLGFRPGLYWRLCWKFVSPAFLL 537

  Fly   560 CILVSSVVFMVIRNPTYGAWNADLGMIEQKSYPNWV--MGIALSMILAGVLPMPIVFLM------ 616
            .:::.|:|       ||...     |.::..:|.|.  .|.|:::....::|:.|::..
 Frog   538 FVVIVSIV-------TYKPL-----MYDEYKFPPWANRTGWAIALSSMTLVPIYIIYKFLTMRGS 590

  Fly   617 ---RSFQCLKVDLDIH---QGSIRR 635
               |...|:..:.:.|   ||.||:
 Frog   591 LRERLAYCITPENEHHLVAQGDIRQ 615

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43066	NP_001246408.1	SLC6sbd-B0AT-like	55..617	CDD:271364	210/597 (35%)
slc6a2	XP_017948962.2	SLC5-6-like_sbd	63..622	CDD:444915	217/620 (35%)