DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43066 and slc6a19a.2

DIOPT Version :9

Sequence 1:	NP_001246408.1	Gene:	CG43066 / 37129	FlyBaseID:	FBgn0262476	Length:	721	Species:	Drosophila melanogaster
Sequence 2:	XP_002665492.2	Gene:	slc6a19a.2 / 100334171	ZFINID:	ZDB-GENE-141210-16	Length:	647	Species:	Danio rerio

Alignment Length:	635	Identity:	279/635 - (43%)
Similarity:	417/635 - (65%)	Gaps:	27/635 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 PQRNSVQSVDIPGNEPERAAWSGKMQFFLSIIGYSVGLGNIWRFPYLCQQNGGGAFLIPFMVMLI 102
            |..:.::.:::. ...||..|..|.|:.|:.:|:.|||||:||||||||.:|||||:|||:::|:
Zfish    17 PSHSELEKLELQ-EAGERPKWDNKAQYMLTCVGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLV 80

  Fly   103 LEGIPLFLIELGIGQRMRLGALGVWNTIHPWLGGIGISSCIVTLFVALYYNVIITWVFFYLFNSF 167
            ||||||..:|..||||:|.|::|||.:|:|:|.|:||:|.:|:..|.:|||.||.||.:|.||||
Zfish    81 LEGIPLLHLEFAIGQRLRRGSVGVWRSINPYLLGVGIASMLVSFIVGMYYNTIIAWVMWYFFNSF 145

  Fly   168 RYPLPWSSCPLNG--TGFELEECAKSSETTYFWYRTTLDAAPSMDEPGGLKWWIVLCLMLSWTIV 230
            :.|||||.||:||  ||| :.||.:||...|||||.||:..|.:::.|||:||:||.|:.:||::
Zfish   146 QDPLPWSQCPINGSRTGF-VSECERSSPVDYFWYRKTLNTTPHIEDSGGLQWWMVLSLLCAWTVL 209

  Fly   231 FFIVMKGIQSSGKVVYFTSLFPYIVLTIFFIRGITLRGAGAGLMHMYTPKVEKLLEPTVWLDAAT 295
            :...::||:::||.||.||..||:|||||.|||:||:|:.:|:..::||.|.:||:|..||||..
Zfish   210 WVCCIRGIETTGKAVYITSTLPYLVLTIFLIRGLTLKGSVSGIKFLFTPDVNELLDPQTWLDAGA 274

  Fly   296 QVFYSFGLAFGSLIAFGSYNTPKNNCVRDVLLVSVCNAVTAIYASVVIFAILGFKATVNVDRCVA 360
            |||:||.||||.||||.|||:..|||.:|.:::|:.|.:|:|||::||::|:||:||...|.|:.
Zfish   275 QVFFSFSLAFGGLIAFSSYNSVHNNCEQDAVIISIINGMTSIYAAIVIYSIIGFRATERFDDCLN 339

  Fly   361 SNTEILV------KNKLLGLNDTQGYEQAMSLLNGTELLRLQLSECSLAHELDNAAEGTGLAFIV 419
            .|...|:      :..::..|.|:..:| :::.....:..|||..|.:...|....|||||||||
Zfish   340 GNILSLLNAFDLPEGSIIEGNYTEAIQQ-LNISRPDIIQELQLKTCDMQTFLSQGVEGTGLAFIV 403

  Fly   420 FTQAIVELPGAPFWAVLFFTMLLSLGLGSQIGILEGMLCTLFDIDII-KRVKKQHVTGVVCLFCF 483
            ||:||.::|.:|.|:||||.||..|||.:..|.:||::..|.|:||: |...|:..|.:||:..|
Zfish   404 FTEAITKMPVSPLWSVLFFIMLFCLGLSTMFGSIEGVVVPLQDLDILPKNWPKEAYTALVCVVSF 468

  Fly   484 IVGFIFCTGAGEYWLKMFDSFAGTIGLVVVALMEMIAVIFIYGHERFTEDIFQMTGYRPGRYWQW 548
            ....||..|:|||||.:||.||.:|.|:::|..||:||.::||.:||.:||..|.|::|..:||.
Zfish   469 AFAIIFAQGSGEYWLALFDGFAVSIPLLIIAFCEMMAVSYVYGIDRFNDDIKFMIGHKPNIFWQA 533

  Fly   549 TWRYIGPVIMVCILVSSVVFMVIRNPTYGAWNAD---LGMIEQKSYPNWVMGIALSMILAG--VL 608
            |||.|.|:|::.|.:...|..|.:..||.||:.:   ...:....||.|:.  |:..||||  ||
Zfish   534 TWRLISPLIVLVIFLFYFVTTVSKKLTYIAWDPESENFPTLSVLPYPGWIS--AIIFILAGIPVL 596

  Fly   609 PMPIVFLMRSF--QCLKVDLDIHQGSIRRNETTASTKEMIDNDDDDDEDD 656
            .:|.|.|:|..  :|.|.: :.|     ..||..|..:.:...::.::::
Zfish   597 VIPTVALVRLIRNRCCKKE-ETH-----ATETPYSISDRVQMMEETEQNN 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43066	NP_001246408.1	SLC6sbd-B0AT-like	55..617	CDD:271364	270/575 (47%)
slc6a19a.2	XP_002665492.2	SLC5-6-like_sbd	33..613	CDD:294310	272/583 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48419
OrthoDB	1	1.010	-	-		D251682at33208
OrthoFinder	1	1.000	-	-		FOG0001784
OrthoInspector	1	1.000	-	-		otm25048
orthoMCL	1	0.900	-	-		OOG6_101967
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	10	9.790