DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43066 and slc6a18

DIOPT Version :9

Sequence 1:	NP_001246408.1	Gene:	CG43066 / 37129	FlyBaseID:	FBgn0262476	Length:	721	Species:	Drosophila melanogaster
Sequence 2:	NP_001108369.1	Gene:	slc6a18 / 100141332	ZFINID:	ZDB-GENE-080219-9	Length:	618	Species:	Danio rerio

Alignment Length:	595	Identity:	283/595 - (47%)
Similarity:	399/595 - (67%)	Gaps:	25/595 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 TAPQRNSVQSVDIPGNEPERAAWSGKMQFFLSIIGYSVGLGNIWRFPYLCQQNGGGAFLIPFMVM 100
            ||.:.:|||         ||..|..|:|:.|:.:|::||||||||||||||..||||||||:::.
Zfish     3 TASETSSVQ---------ERPKWDNKVQYLLTCVGFAVGLGNIWRFPYLCQIYGGGAFLIPYLIA 58

  Fly   101 LILEGIPLFLIELGIGQRMRLGALGVWNTIHPWLGGIGISSCIVTLFVALYYNVIITWVFFYLFN 165
            |:.||:||..:||.|||.:|.|::|||::|.|.|||:|::|.:|:..|.|:||.|:.||.:|.|:
Zfish    59 LVFEGLPLLYLELAIGQSLRKGSIGVWHSISPLLGGVGVASMVVSFLVGLFYNTILAWVLWYFFH 123

  Fly   166 SFRYPLPWSSCPLNGT--GFELEECAKSSETTYFWYRTTLDAAPSMDEPGGLKWWIVLCLMLSWT 228
            ||..|||||.||:|..  |: :|||..|:...|:|||.||:.:|.:::.|.|:|.:||||..:|:
Zfish   124 SFEDPLPWSQCPINDNLEGY-VEECVSSTPVNYYWYRQTLNISPDIEQSGSLQWTLVLCLATAWS 187

  Fly   229 IVFFIVMKGIQSSGKVVYFTSLFPYIVLTIFFIRGITLRGAGAGLMHMYTPKVEKLLEPTVWLDA 293
            ||:...::||::.||.||.|:.|||:|||||.:|.:||.||..||.:::||....|..|.|||||
Zfish   188 IVYICFIRGIETIGKAVYVTATFPYLVLTIFLVRALTLPGATDGLQYLFTPDWTLLTNPQVWLDA 252

  Fly   294 ATQVFYSFGLAFGSLIAFGSYNTPKNNCVRDVLLVSVCNAVTAIYASVVIFAILGFKATVNVDRC 358
            |||:|:|..||||.||||.|||..||:|.||.|.|.:.|:.|::|||:.||||||||||.|.:.|
Zfish   253 ATQIFFSLSLAFGGLIAFSSYNPKKNDCERDALFVGIINSATSLYASIPIFAILGFKATSNFNSC 317

  Fly   359 VASNTEILVKNKLLGLND----TQGYEQAMSLLNGTE---LLRLQLSECSLAHELDNAAEGTGLA 416
            |.||  ||.......:.|    .:.|:..:..||.::   :..|.|..|.|.:.||.:|.|||||
Zfish   318 VNSN--ILDLTNAFDIGDRNITIENYDSWLRDLNASDPDRVSSLNLKHCVLKNFLDQSASGTGLA 380

  Fly   417 FIVFTQAIVELPGAPFWAVLFFTMLLSLGLGSQIGILEGMLCTLFDIDIIKR-VKKQHVTGVVCL 480
            |||||:|::|:||:..||||||.||.||||.|..|.|||:|..|.|:.::.| :.|:..||::|:
Zfish   381 FIVFTEAVIEMPGSQVWAVLFFVMLFSLGLSSMFGNLEGVLTPLLDLHMVPRWMPKEIFTGLICV 445

  Fly   481 FCFIVGFIFCTGAGEYWLKMFDSFAGTIGLVVVALMEMIAVIFIYGHERFTEDIFQMTGYRPGRY 545
            ..|:|..||..|:|.|||::|:|:.|::.|:|:|..|:|||:..||.:||::||.||||.||..:
Zfish   446 VNFLVALIFTLGSGNYWLEIFNSYVGSVPLLVIAFFEIIAVVCFYGIKRFSDDIEQMTGRRPNLF 510

  Fly   546 WQWTWRYIGPVIMVCILVSSVVFMVIRNPTYGAWN---ADLGMIEQKSYPNWVMGIALSMILAGV 607
            |:..|..|.||:::.:||:.||..|.::|||.|||   .:....|:|.|..||..|.:.:....|
Zfish   511 WRCCWMGISPVMLLVVLVAYVVVQVQKHPTYPAWNPQYENFPETEEKPYSTWVFSICVLLSSVPV 575

  Fly   608 LPMPIVFLMR 617
            :.:|||.|.|
Zfish   576 ISIPIVALYR 585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43066	NP_001246408.1	SLC6sbd-B0AT-like	55..617	CDD:271364	276/574 (48%)
slc6a18	NP_001108369.1	SLC5-6-like_sbd	12..587	CDD:294310	278/577 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48419
OrthoDB	1	1.010	-	-		D251682at33208
OrthoFinder	1	1.000	-	-		FOG0001784
OrthoInspector	1	1.000	-	-		otm25048
orthoMCL	1	0.900	-	-		OOG6_101967
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4904
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.960