DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30116 and MDV1

DIOPT Version :9

Sequence 1:	NP_725799.1	Gene:	CG30116 / 37126	FlyBaseID:	FBgn0028496	Length:	1922	Species:	Drosophila melanogaster
Sequence 2:	NP_012423.1	Gene:	MDV1 / 853332	SGDID:	S000003648	Length:	714	Species:	Saccharomyces cerevisiae

Alignment Length:	667	Identity:	149/667 - (22%)
Similarity:	249/667 - (37%)	Gaps:	209/667 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   951 SDSELLLTGSEDATVLVWHVGLRERRAHIKNAHTAPITGVAAGANNTLIISSSEDASIAITDLAS 1015
            :|.:||..|.|:.       .||      ||| :...|.:..|..:.|.|     |.:||.:
Yeast   123 ADGKLLTEGGENE-------NLR------KNA-SKKETSLFQGFKSYLPI-----AELAIEN--- 165

  Fly  1016 GKLRHRITHHRGPVSGIVVAGACDVLISGGLDRTICVWDLDNF---------------------- 1058
               ..|:.:.....||.|  ||.||: |...:|.....:|.||
Yeast   166 ---TERLNYDTNGTSGTV--GAKDVM-SKTNERDEIHTELPNFQDSFLIPPGVETKKISSSYSPS 224

  Fly  1059 -------TLLNTMQMTSAVLRIDISWNSVFLLALCEDNALYVRTLATGKELHTLKGHKSKIRSIS 1116
                   ||:|:::.      ::|..||    .|.|...:.|       |:..|:..|.|:
Yeast   225 ALKSFSQTLVNSLEF------LNIQKNS----TLSEIRDIEV-------EVENLRQKKEKL---- 268

  Fly  1117 IGKDSQRCVVGCDDTRALIYDMHAGKLVRSLPPNPGPVTAVHAMDNDDFLVTVGGNKITFYSFRN 1181
            :||     :...:..:.|:.|                 ......|..|||...|...|...|..|
Yeast   269 LGK-----IANIEQNQLLLED-----------------NLKQIDDRLDFLEEYGLEVIEANSDEN 311

  Fly  1182 EELYVNPYSRHPRRKRSLKRHA--------QAQRSPSTTLPPITCFDLSRDSQQM---------- 1228
            .|      ......:::||..|        ::..|.::.|||       |..||:
Yeast   312 AE------DDGMSERKALKNDAIRNEGVTTESISSEASNLPP-------RRRQQLRDDNSLNRLG 363

  Fly  1229 ---AIASGRHVHLMRINTPEYQ----------CTLEGHTAGVSCLKF-APNGEFLATGSEDRLVH 1279
               :.:..||    |.:.|.:|          ..:..|...::||.| ||.|.....|..|..|.
Yeast   364 AFYSKSKKRH----RKSFPTFQQLYEPGTKIGSIMSTHDDFLTCLDFDAPFGTLCTAGYLDHTVK 424

  Fly  1280 IWNLA----LGEICNSFKGHTAPVVKVVVLMDSLRVISTDRDSMLLVWMAHSGNLLQTIQGPYKS 1340
            ||:|:    :||:.    ||.|.:..:.:..|...:::..||:.|.:|   :.||.|.:....::
Yeast   425 IWDLSKQNKIGELA----GHLATINCMQINRDYGTLVTGGRDAALKLW---NLNLAQQLYQETQN 482

  Fly  1341 L-SVTNNMRFAVSTNGDNTLKIWSLTQEDEKYSVSHSDEITCFEISADSVHIISGSRDMSLKVWQ 1404
            | |.||:    :.:...:|.:             :|:||:|.  :|.|...::|||:|.:::.|.
Yeast   483 LTSPTNH----IDSPCVHTFE-------------AHTDEVTA--LSLDPSFLVSGSQDRTIRQWD 528

  Fly  1405 ATGGKLSQ--------VLVGHSDAVTCVAVSVTNKTQ-------------VLSGSKDMNLILWDL 1448
            ...||..|        ||...::.....:..:|.:.:             :.:|:||..:.||||
Yeast   529 LRSGKCLQTIDLSFANVLTTSTNVDLSKSTLLTQRNERPSIGALQSFDAALATGTKDGVVRLWDL 593

  Fly  1449 LTGEEVHTLAGHLGPVIGVKVSADGSTAVSGSDDKTLIVWETKRGLALTSLQMHVPFTHFDISLE 1513
            .:|:.:.||.||...:..:|.  |.:..|:||.|:|:.:|:.:.||.........|....|:..|
Yeast   594 RSGKVIRTLKGHTDAITSLKF--DSACLVTGSYDRTVRIWDLRTGLLNKFHAYSAPVLSLDLFQE 656

  Fly  1514 VSRVL------VQLVDS 1524
            .:.|:      ||:.||
Yeast   657 NAAVVVADEPSVQIYDS 673

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30116	NP_725799.1	AAA_16	359..505	CDD:289934
		WD40 repeat	901..937	CDD:293791
		WD40	933..1282	CDD:238121	82/391 (21%)
		WD40 repeat	942..982	CDD:293791	8/30 (27%)
		WD40 repeat	988..1024	CDD:293791	8/35 (23%)
		WD40	1022..1484	CDD:225201	119/548 (22%)
		WD40 repeat	1029..1064	CDD:293791	15/63 (24%)
		WD40 repeat	1071..1106	CDD:293791	7/34 (21%)
		WD40 repeat	1112..1147	CDD:293791	4/34 (12%)
		WD40 repeat	1216..1252	CDD:293791	8/58 (14%)
		WD40	1248..1502	CDD:238121	70/280 (25%)
		WD40 repeat	1258..1294	CDD:293791	14/40 (35%)
		WD40 repeat	1299..1335	CDD:293791	8/35 (23%)
		WD40 repeat	1340..1374	CDD:293791	5/34 (15%)
		WD40 repeat	1379..1415	CDD:293791	12/43 (28%)
		WD40 repeat	1421..1458	CDD:293791	10/49 (20%)
		WD40 repeat	1464..1488	CDD:293791	7/23 (30%)
MDV1	NP_012423.1	Mdv1	123..171	CDD:402923	18/72 (25%)
		WD40	397..713	CDD:238121	78/305 (26%)
		WD40 repeat	402..439	CDD:293791	14/40 (35%)
		WD40 repeat	444..499	CDD:293791	13/61 (21%)
		WD40 repeat	506..539	CDD:293791	11/34 (32%)
		WD40 repeat	546..603	CDD:293791	11/56 (20%)
		WD40 repeat	648..683	CDD:293791	7/26 (27%)
		WD40 repeat	690..712	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4155
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900