DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30116 and CDC4

DIOPT Version :9

Sequence 1:	NP_725799.1	Gene:	CG30116 / 37126	FlyBaseID:	FBgn0028496	Length:	1922	Species:	Drosophila melanogaster
Sequence 2:	NP_116585.1	Gene:	CDC4 / 850539	SGDID:	S000001885	Length:	779	Species:	Saccharomyces cerevisiae

Alignment Length:	670	Identity:	128/670 - (19%)
Similarity:	225/670 - (33%)	Gaps:	262/670 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   824 DVLTRDPMQLGSQLISWLRPISEHDDDDNSL-----LSMTVRSATA-WCDGYAVPLLVPLTGWLP 882
            |::|..|.::..::.::|    :.:|..|||     .:..:|.:|: |     ..||
Yeast   273 DLITSLPFEISLKIFNYL----QFEDIINSLGVSQNWNKIIRKSTSLW-----KKLL-------- 320

  Fly   883 APLPSQIRTMTVSGTGCIRAVWLAPSKQHLILATSSGDVQQWHIMSNSLDHIF------------ 935
                  |....||..| ..::.|..|:::..|:      ||..:..:.|::||
Yeast   321 ------ISENFVSPKG-FNSLNLKLSQKYPKLS------QQDRLRLSFLENIFILKNWYNPKFVP 372

  Fly   936 -----KGH-TAAVTCLLVAPQSDSELLLTGSEDATVLVWHVGLRERRAHIKNAHTAPITGVAAGA 994
                 :|| |:.:|||    |.:...::||::|..:.|:
Yeast   373 QRTTLRGHMTSVITCL----QFEDNYVITGADDKMIRVY-------------------------- 407

  Fly   995 NNTLIISSSEDASIAITDLASGKLRHRITHHRGPVSGIVVAGACDVLISGGLDRTICVWDLDNFT 1059
                             |..:.|...:::.|.|.|..:..|.. .:|:||..|||:.|||:..
Yeast   408 -----------------DSINKKFLLQLSGHDGGVWALKYAHG-GILVSGSTDRTVRVWDIKK-- 452

  Fly  1060 LLNTMQMTSAVLRIDISWNSVFLLALCEDNALYVRTLATGKELHTLKGHKSKIRSISI--GKDSQ 1122
                                                   |...|..|||.|.:|.:.|  .|:.:
Yeast   453 ---------------------------------------GCCTHVFKGHNSTVRCLDIVEYKNIK 478

  Fly  1123 RCVVGCDDTRALIYDMHAGKLVR--SLPPNPGPVTAVHAMDNDDFLVTVGGNKITFYSFRNEELY 1185
            ..|.|..|.     .:|..||.:  |:|.        |..::|..||           |...|
Yeast   479 YIVTGSRDN-----TLHVWKLPKESSVPD--------HGEEHDYPLV-----------FHTPE-- 517

  Fly  1186 VNPYSRHPRRKRSLKRHAQAQRSPSTTLPPITCFDLSRDSQQMAIASGRHVHLMRINTPEYQCTL 1250
            .|||                                                        :...|
Yeast   518 ENPY--------------------------------------------------------FVGVL 526

  Fly  1251 EGHTAGVSCLKFAPNGEFLATGSEDRLVHIWNLALGEICNSFKGHTAPVVKVVVLMDSLRVISTD 1315
            .||.|.|..:  :.:|..:.:||.|..:.:|::|..:......|||..:...:...:..|.||..
Yeast   527 RGHMASVRTV--SGHGNIVVSGSYDNTLIVWDVAQMKCLYILSGHTDRIYSTIYDHERKRCISAS 589

  Fly  1316 RDSMLLVW----------MAHSGN----------LLQTIQGPYKSLSVTN-NMRFAVSTNGDNTL 1359
            .|:.:.:|          .:::.|          .:.|:||....:.:.. :.:|.||...|.::
Yeast   590 MDTTIRIWDLENIWNNGECSYATNSASPCAKILGAMYTLQGHTALVGLLRLSDKFLVSAAADGSI 654

  Fly  1360 KIWSLTQEDEKYSVSHSD--EITCFEISADSVHIISGSRDMSLKVWQATGGKL--SQVLVGHSDA 1420
            :.|.......|:|..|::  .||.|.:| |:: ::|||.: ...::....|||  :.:|   .||
Yeast   655 RGWDANDYSRKFSYHHTNLSAITTFYVS-DNI-LVSGSEN-QFNIYNLRSGKLVHANIL---KDA 713

  Fly  1421 VTCVAVSVTNKTQVLSGSKD 1440
            ....:|:...||.|.:..||
Yeast   714 DQIWSVNFKGKTLVAAVEKD 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30116	NP_725799.1	AAA_16	359..505	CDD:289934
		WD40 repeat	901..937	CDD:293791	8/52 (15%)
		WD40	933..1282	CDD:238121	63/370 (17%)
		WD40 repeat	942..982	CDD:293791	8/39 (21%)
		WD40 repeat	988..1024	CDD:293791	2/35 (6%)
		WD40	1022..1484	CDD:225201	90/448 (20%)
		WD40 repeat	1029..1064	CDD:293791	11/34 (32%)
		WD40 repeat	1071..1106	CDD:293791	2/34 (6%)
		WD40 repeat	1112..1147	CDD:293791	9/38 (24%)
		WD40 repeat	1216..1252	CDD:293791	1/35 (3%)
		WD40	1248..1502	CDD:238121	51/218 (23%)
		WD40 repeat	1258..1294	CDD:293791	6/35 (17%)
		WD40 repeat	1299..1335	CDD:293791	7/55 (13%)
		WD40 repeat	1340..1374	CDD:293791	7/34 (21%)
		WD40 repeat	1379..1415	CDD:293791	11/37 (30%)
		WD40 repeat	1421..1458	CDD:293791	6/20 (30%)
		WD40 repeat	1464..1488	CDD:293791
CDC4	NP_116585.1	CDC4_D	228..272	CDD:407099
		F-box-like	275..319	CDD:403981	10/52 (19%)
		WD40	374..693	CDD:238121	91/494 (18%)
		WD40 repeat	385..420	CDD:293791	10/81 (12%)
		WD40 repeat	426..461	CDD:293791	12/76 (16%)
		WD40 repeat	466..527	CDD:293791	20/142 (14%)
		WD40 repeat	534..567	CDD:293791	6/34 (18%)
		WD40 repeat	573..629	CDD:293791	7/55 (13%)
		WD40 repeat	637..667	CDD:293791	6/29 (21%)
		WD40 repeat	716..751	CDD:293791	6/18 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7467
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.950