DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG30116 and Apaf1

DIOPT Version :10

Sequence 1:NP_725799.1 Gene:CG30116 / 37126 FlyBaseID:FBgn0028496 Length:1922 Species:Drosophila melanogaster
Sequence 2:NP_076469.1 Gene:Apaf1 / 78963 RGDID:620575 Length:1249 Species:Rattus norvegicus


Alignment Length:1481 Identity:279/1481 - (18%)
Similarity:488/1481 - (32%) Gaps:481/1481 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   212 LLRRTQIEREVSQAMA---LTSEKILAVFRERAAQCSKGDVEAAERLRKIKDELTMNLSTDNHTT 273
            |..:..:|:::..:..   :.|..:|.|..|...:......:.|..|.|      |.|:.||:..
  Rat    10 LQHKEALEKDIKTSYIMDHMISNGVLTVVEEEKVKSQATQYQRAAALIK------MILNKDNYAY 68

  Fly   274 LVVPGSAASEAIDPDNEDHESY-------------LSKFKNKVTD------KLRLLIEAHITNDP 319
            :....:..          ||.|             :|....|.||      ...:|.|..:...|
  Rat    69 ISFYNALL----------HEGYKDLAGLLHSGLPLVSSSSGKDTDGGNTSFVRTVLCEGGVPQRP 123

  Fly   320 DVIKGRKKTVQEIFH---------------------EHATHLRILREHTDSDALVES-------- 355
            .:...|||.|..|..                     :.......:|:|    ||:|.        
  Rat   124 VIFVTRKKLVSAIQQKLWKLNGEPGWVTIYGMAGCGKSVLAAEAVRDH----ALLEGCFSGGVHW 184

  Fly   356 -RVPQQLRQNLMANFRNGSRHAPYFLCGADGSGKSAILCHLYGQVGSWFGSTRVHRVIRFAK--- 416
             .:.:|.:..|:...:|                    ||...||..|:  |.|:...|..||   
  Rat   185 VSIGKQDKSGLLMKLQN--------------------LCTRLGQEESF--SQRLPLNIEEAKDRL 227

  Fly   417 ------ATPRSAYNLE------LLRVICQQISIIFNIPEGYLPKDASFDPLYINTWFQNLLRRVE 469
                  ..|||...|:      :|:....|..|:....:..: .|:...|.|:......|   .:
  Rat   228 RVLMLRKHPRSLLILDDVWDPWVLKAFDNQCQILLTTRDKSV-TDSVMGPKYVIPVESGL---GK 288

  Fly   470 DMGNDVLFLFI----DDL----HLL------NPLDCDIVTALSWLPTSLP--WNVQIICSSTTPV 518
            :.|.::|.||:    :||    |.:      :||   :|:.:..|....|  |...:        
  Rat   289 EKGLEILSLFVNMKKEDLPVEAHSIIKECKGSPL---VVSLVGALLRDFPNRWAYYL-------- 342

  Fly   519 EQLKFTPMQRDRFKSIEYQFDLNMGDYATKLKIPPQCIPGDVSFALYVEQQFDQLERHYGRQAVG 583
            .||:....:|.| ||..|.::..                 |.:.::.||...:.::.:|     .
  Rat   343 RQLQNKQFKRIR-KSSSYDYEAL-----------------DEAMSISVEMLREDIKDYY-----T 384

  Fly   584 DLA---------SYITCSEYGLSETELLELLMPTDDPESLIETKNGHFSFATFKKIHREMDLLLL 639
            ||:         :.:.|..:.|...|:.::|....:...|...:||. ||..:            
  Rat   385 DLSILQKDVKVPTKVLCVLWDLETEEVEDILQEFVNKSLLFCNRNGK-SFCYY------------ 436

  Fly   640 LHDKIMSGKVLIQWRHNYCASVAKRRYMDVQRTRSLHCELANLFFPQDEDESTLENESNRSESKS 704
            |||                                |..:..              .|.|||:   
  Rat   437 LHD--------------------------------LQVDFL--------------TEKNRSQ--- 452

  Fly   705 VISLKDRDREKDSLSAVSAVSAGRKSSSTH----HNDDTSTFYNPIAADVSYSMRHVEESWHHLM 765
               |:|..|:        .|:..::....|    ..:|...:||.:|..::.:..|.|       
  Rat   453 ---LQDLHRK--------MVTQFQRYHQPHTLSPGQEDCMYWYNFLAYHMASAGMHKE------- 499

  Fly   766 RSDDTTRFKQIAVC----NFDFLLAAVQTVSISYL-------RCLIEHVRCYILDRDIELIYYTI 819
                        :|    :.|::.|..:.|..::|       |.:::...|.:.:...|.    :
  Rat   500 ------------LCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAVCENFQEF----L 548

  Fly   820 RKSSDVLTRDP----MQLG------SQLISWLRPISEHDDDDNSLLSMTVRSATAWCDGYAVPLL 874
            ..:..:|.|.|    :|||      |::....:..::.:.|       |.|....|.:...:..|
  Rat   549 SLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVD-------TGRLYLEWINKKTIKNL 606

  Fly   875 VPLTGWLPAPLPSQIRTMT--------------VSGTGCIRA--VWLAPSKQHLI---------- 913
            ..|.          :|..|              ::..|..:.  |:.|.:.:.|:          
  Rat   607 SRLV----------VRPHTDAVYHACFSQDGQRIASCGADKTLQVFKAETGEKLLDIKAHEDEVL 661

  Fly   914 ----------LATSSGD--VQQWHIMSNSLDHIFKGHTAAVTCLLVAPQSDSELLLTGSEDATVL 966
                      :||.|.|  |:.|...:..|.|.::.|:..|.|.....:|:..||.|||.|:.:.
  Rat   662 CCAFSSDDSYIATCSVDKKVKIWDSGTGKLVHTYEEHSEQVNCCHFTNKSNHLLLATGSNDSFLK 726

  Fly   967 VWHVGLRERRAHIKNAHTAPITGVAAGANNTLIISSSEDASIAITDLASGKLRHRITHHR----- 1026
            :|.:..:|.| :....||..:|......::.|:.|.|.|.::.:.|:.|...:..|...|     
  Rat   727 LWDLNQKECR-NTMFGHTNSVTHCRFSPDDELLASCSADGTLKLWDVRSANEKKSINVKRFFLSS 790

  Fly  1027 -GPVSGIVVAGACDVLISGGLDRTICVWDLDNFTLLNTMQMTSAVLRIDISWNSVFLLALCEDNA 1090
             .|...:.|...|            |.|..|...::  :...:.||.:||..:.:.         
  Rat   791 EDPPEDVEVIVKC------------CSWSADGDRII--VAAKNKVLLLDIHTSGLL--------- 832

  Fly  1091 LYVRTLATGKELHTLKGHKSKIR--------SISIGKDSQRCV-VGCDDTRALIYDMHAGKLVRS 1146
                     .|:||  ||.|.|:        .:::...||.|| :...|:|..:.|..       
  Rat   833 ---------TEIHT--GHHSTIQYCDFSPYDHLAVIALSQYCVELWNIDSRVKVADCR------- 879

  Fly  1147 LPPNPGPVTAVHAM----DNDDFLVTVGGNKITFYSFR----NEELYVNPYSRHPRRKRSLKRHA 1203
                 |.::.||.:    |...||.......|..:..|    |..:.             ||:..
  Rat   880 -----GHLSWVHGVMFSPDGSSFLTASDDQTIRVWETRKVCKNSAIV-------------LKQEI 926

  Fly  1204 QAQRSPSTTLPPITCFDLSRDSQQMAIASGRHVHLMRINTPEYQCTLEGHTAGVSCLKFAPNGEF 1268
            ......:..:  :...|..|..|.:|..:|:..:|     ||.|         |||...:|:.|:
  Rat   927 DVVFQENEMM--VLAVDNIRGLQLIAGKTGQIDYL-----PEAQ---------VSCCCLSPHLEY 975

  Fly  1269 LATGSEDRLVHIWNLALGEICNSFKGHTAPVVKVVVLMDSLRVISTDRDSMLLV--WMAHSGNLL 1331
            :|.|.|:..:.|..|....:.:|..||...|..:....|...:||:..||::.|  |.......|
  Rat   976 VAFGDEEGAIKIIELPNNRVFSSGIGHKKAVRHIQFTADGKTLISSSEDSVIQVWNWQTEEYVFL 1040

  Fly  1332 QTIQGPYKSLSVTNNMRFAVSTNGDNTLKIWS-LTQEDEKYSVSHSDEITCFEISADSVHIISGS 1395
            |..|...|...:..:.|. :|.:.|.|:|:|: :|...|:....|...:....||:|:....|.|
  Rat  1041 QAHQETVKDFRLLRDSRL-LSWSFDGTVKVWNVITGRIERDFTCHQGTVLSCAISSDATKFSSTS 1104

  Fly  1396 RDMSLKVWQATGGKLSQVLVGHSDAVTCVAVSVTNKTQVLSGSKDMN--LILWDLLTGEEVHTLA 1458
            .|.:.|:|..........|.||:..|.|.|.|:..   :|..:.|.|  :.:|::..|:.:|..|
  Rat  1105 ADKTAKIWSFELPSPLHELKGHNSCVRCSAFSLDG---ILLATGDDNGEIRIWNVSDGQLLHLCA 1166

  Fly  1459 GHLGPVIGVKVSADGSTAVSG--------SDDKTLIV--------WETKRG 1493
                     .:|.:..||..|        |.|:.::|        |....|
  Rat  1167 ---------PISIEEGTATHGGWVTDVCFSPDRKMLVSAGGYLKWWNVVTG 1208

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG30116NP_725799.1 WD40 <897..1057 CDD:441893 41/189 (22%)
WD40 repeat 901..937 CDD:293791 11/59 (19%)
WD40 repeat 942..982 CDD:293791 12/39 (31%)
WD40 repeat 988..1024 CDD:293791 8/35 (23%)
WD40 991..1491 CDD:441893 116/543 (21%)
WD40 repeat 1029..1064 CDD:293791 5/34 (15%)
WD40 repeat 1071..1106 CDD:293791 6/34 (18%)
WD40 repeat 1112..1147 CDD:293791 8/43 (19%)
WD40 repeat 1216..1252 CDD:293791 9/35 (26%)
WD40 repeat 1258..1294 CDD:293791 10/35 (29%)
WD40 repeat 1299..1335 CDD:293791 10/37 (27%)
WD40 repeat 1340..1374 CDD:293791 8/34 (24%)
WD40 repeat 1379..1415 CDD:293791 8/35 (23%)
WD40 repeat 1421..1458 CDD:293791 10/38 (26%)
WD40 repeat 1464..1488 CDD:293791 7/39 (18%)
Apaf1NP_076469.1 CARD_APAF1 7..92 CDD:260034 16/97 (16%)
NB-ARC 129..374 CDD:395745 56/303 (18%)
APAF1_C 453..587 CDD:465560 26/164 (16%)
WD40 <608..912 CDD:441893 70/360 (19%)
WD 1-1 613..652 5/38 (13%)
WD40 repeat 623..655 CDD:293791 4/31 (13%)
WD 1-2 655..694 7/38 (18%)
WD40 repeat 661..697 CDD:293791 8/35 (23%)
WD 1-3 697..738 13/41 (32%)
WD40 repeat 702..740 CDD:293791 12/38 (32%)
WD 1-4 741..780 9/38 (24%)
WD40 repeat 747..789 CDD:293791 9/41 (22%)
WD 1-5 796..837 10/72 (14%)
WD40 repeat 801..837 CDD:293791 9/67 (13%)
WD40 805..1235 CDD:441893 105/480 (22%)
WD 1-6 838..877 10/38 (26%)
WD40 repeat 843..882 CDD:293791 9/50 (18%)
WD 1-7 880..910 7/29 (24%)
WD40 repeat 885..909 CDD:293791 6/23 (26%)
Interpropeller linker. /evidence=ECO:0000250 910..921 2/10 (20%)
WD 2-1 922..958 7/37 (19%)
WD 2-2 959..998 14/52 (27%)
WD40 repeat 964..1001 CDD:293791 11/36 (31%)
WD 2-3 1001..1040 10/38 (26%)
WD40 repeat 1006..1030 CDD:293791 6/23 (26%)
WD 2-4 1042..1080 10/38 (26%)
WD40 repeat 1048..1082 CDD:293791 9/34 (26%)
WD 2-5 1083..1122 9/38 (24%)
WD40 repeat 1089..1124 CDD:293791 8/34 (24%)
WD 2-6 1125..1164 11/41 (27%)
WD40 repeat 1130..1174 CDD:293791 12/55 (22%)
WD 2-7 1176..1213 6/33 (18%)
WD40 repeat 1181..1203 CDD:293791 3/21 (14%)
WD 2-8 1214..1249
Blue background indicates that the domain is not in the aligned region.

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