DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG30116 and TEP1

DIOPT Version :9

Sequence 1:NP_725799.1 Gene:CG30116 / 37126 FlyBaseID:FBgn0028496 Length:1922 Species:Drosophila melanogaster
Sequence 2:NP_009041.2 Gene:TEP1 / 7011 HGNCID:11726 Length:2627 Species:Homo sapiens


Alignment Length:1970 Identity:389/1970 - (19%)
Similarity:675/1970 - (34%) Gaps:588/1970 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 PIDESVLNALRGVTSAHTRLPKPLLIKIYVASLKQEFNQERRMLLELVGPELQSLYDDRQIELEF 68
            |::|...:.|..|:....|     .|:::::|..::.:.||.:||..|.|.||:.....:|.|..
Human   879 PLEEDTPSPLAPVSQQGWR-----SIRLFISSTFRDMHGERDLLLRSVLPALQARAAPHRISLHG 938

  Fly    69 VDMHFGTGDLEVHQLERDPYLIHDYLHEIDTCHAHTKSV-FFMVLVGDGIGRQLLPTKIDEDIFS 132
            :|:.:|..:.|..:           ..:::.|....::. .|:.::|...|              
Human   939 IDLRWGVTEEETRR-----------NRQLEVCLGEVENAQLFVGILGSRYG-------------- 978

  Fly   133 AVLADQQTSADHEAMLVKWYERDASQTQRQLKQDYRLMNVDAWLAESQRMQSFLEQAFQSLLQGS 197
             .:.......||...  .|            .|.|                              
Human   979 -YIPPSYNLPDHPHF--HW------------AQQY------------------------------ 998

  Fly   198 GASGRSPDFMERVQLLRRTQIEREVSQAMALTSEKILAVFRERAAQCSKGDV----------EAA 252
             .||||...||.:|.|.|.|..:..:||        |..||:.:...|..|.          |||
Human   999 -PSGRSVTEMEVMQFLNRNQRLQPSAQA--------LIYFRDSSFLSSVPDAWKSDFVSESEEAA 1054

  Fly   253 ERLRKIKDELTMNLSTDNHTTLVVP----GSAASEAIDPDNEDHESYLSKFKNKVTDKLRL---- 309
            .|:.::|..|:.....   |....|    |.||........|:....:.:....:..||.|    
Human  1055 RRISELKSYLSRQKGI---TCRRYPCEWGGVAAGRPYVGGLEEFGQLVLQDVWNMIQKLYLQPGA 1116

  Fly   310 LIEAHIT-NDPDVIKGRKKTVQEIFHEHATHLRILREHTDSDALVESRVPQQLRQNLMANFRNGS 373
            |:|..:: .|.|:::.   |.|::            :...|.|  ..|:.|...|.||       
Human  1117 LLEQPVSIPDDDLVQA---TFQQL------------QKPPSPA--RPRLLQDTVQRLM------- 1157

  Fly   374 RHAPY----FLCGADGSGKSAILCHLYGQVGSWFGSTRVHRV-IRFAKATPRSAYNLELLRVICQ 433
              .|:    .:.|..|.||:|.|..|...:.:..|:.....| ..|:.|.|.....|.|||.:|.
Human  1158 --LPHGRLSLVTGQSGQGKTAFLASLVSALQAPDGAKVASLVFFHFSGARPDQGLALTLLRRLCT 1220

  Fly   434 QI---------------SIIFNIPEGYLPKDA-SFDPLYINTWFQNLLRRVEDMGNDVLFLFIDD 482
            .:               |:::.:.:..|||.| |..|                  .....|.||.
Human  1221 YLRGQLKEPGALPSTYRSLVWELQQRLLPKSAESLHP------------------GQTQVLIIDG 1267

  Fly   483 LHLLNPLDCDIVTALSWLPTSLPWNVQIICSSTT------PVEQ------LKFTPMQRD-RFKSI 534
            ...|...:..:::  .|:|..||..|.::.|.::      .:||      |...|::.. |.:.:
Human  1268 ADRLVDQNGQLIS--DWIPKKLPRCVHLVLSVSSDAGLGETLEQSQGAHVLALGPLEASARARLV 1330

  Fly   535 EYQFDLNMGDYATKLKIPPQCIPGDVSFALYVEQQFDQ------LERHYGR----QAVGDLASYI 589
            ..:..|    |..:|:                |..|:.      ::|..||    :.|.|.....
Human  1331 REELAL----YGKRLE----------------ESPFNNQMRLLLVKRESGRPLYLRLVTDHLRLF 1375

  Fly   590 TCSEYGLSE---------TELLELLMPTDDPE-----------SLIETKNGHFSFATFKKIHREM 634
            |..|. :||         ..||:.::.|.:.|           :|..|::|    .|..::|   
Human  1376 TLYEQ-VSERLRTLPATVPLLLQHILSTLEKEHGPDVLPQALTALEVTRSG----LTVDQLH--- 1432

  Fly   635 DLLLLLHDKIMSGKVLIQWR------HNYCASVAKRRYMD----------VQRTRSLHCE----- 678
                         .||..||      .::..:||.....|          ||..|||..|     
Human  1433 -------------GVLSVWRTLPKGTKSWEEAVAAGNSGDPYPMGPFACLVQSLRSLLGEGPLER 1484

  Fly   679 -LANLFFPQDEDESTLENESNRSESKSVISLKDRDREKDSLSAVSAVSAGRKSSSTHHNDDTSTF 742
             .|.|..|    :..|...:.|...|           :..|...:.:....:...|...|.:.||
Human  1485 PGARLCLP----DGPLRTAAKRCYGK-----------RPGLEDTAHILIAAQLWKTCDADASGTF 1534

  Fly   743 YN--PIA-ADVSYSMRHVEESWHHLMRSDDTTRFKQIAVCNFDFLLAAVQTVSISYLRCLIEHVR 804
            .:  |.| .|:.|          ||::|.:.....:. :.|...:.|.::...:|.   |:|...
Human  1535 RSCPPEALGDLPY----------HLLQSGNRGLLSKF-LTNLHVVAAHLELGLVSR---LLEAHA 1585

  Fly   805 CY----------ILDRDIELIYYTIRKSSDVLTRDPMQLGSQLISWLRPISEHDDDDNSLLSM-- 857
            .|          :.:.|:.:....:|:.:.:|::.|..|..|..:  :|:........||||.  
Human  1586 LYASSVPKEEQKLPEADVAVFRTFLRQQASILSQYPRLLPQQAAN--QPLDSPLCHQASLLSRRW 1648

  Fly   858 ----TVRSATAWCDGYAVPLLVPLTGWLPAPLP---SQIRTMTVSGTGCIRAVWLAPSKQHLILA 915
                |:|                   ||..|..   .|..:::::.:....||..:.:.|...:.
Human  1649 HLQHTLR-------------------WLNKPRTMKNQQSSSLSLAVSSSPTAVAFSTNGQRAAVG 1694

  Fly   916 TSSG-----DVQQWHIMSNSLDHIFKGHTAAVTCLLVAPQSDSELLLTGSEDATVLVWHV--GLR 973
            |::|     |::.|....:    :..|......||.:   ||..|.|| :.|..:.:|.:  |.|
Human  1695 TANGTVYLLDLRTWQEEKS----VVSGCDGISACLFL---SDDTLFLT-AFDGLLELWDLQHGCR 1751

  Fly   974 ERRAHIKNAHTAPITGVAAGANNTLIISSSEDASIAITDLASGKLRHRITHHRG-------PVSG 1031
            ..:.   .||...|||.....:..|:.:......:.:.|...|:|..:.|:.:.       |...
Human  1752 VLQT---KAHQYQITGCCLSPDCRLLATVCLGGCLKLWDTVRGQLAFQHTYPKSLNCVAFHPEGQ 1813

  Fly  1032 IVVAGAC----------------DVLISGGLDRTICVWDLDNFTLLNTMQMTSAVLRIDI----- 1075
            ::..|:.                |:...|...||:.         .|......||.|:|.     
Human  1814 VIATGSWAGSISFFQVDGLKVTKDLGAPGASIRTLA---------FNVPGGVVAVGRLDSMVELW 1869

  Fly  1076 SWN-----------------SVFLLALC------EDNALYVRTLATGKELHTLKGHKSKIR---- 1113
            :|.                 ::||.|.|      ||..:.|.:.:.|:.    :||...:.    
Human  1870 AWREGARLAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQVWSGSLGRP----RGHLGSLSLSPA 1930

  Fly  1114 -SISIGKDSQRCVVGCDDTRALIYDMHAGKLVRSLPPNPGPV-----TAVHAMDNDDFLVTVGGN 1172
             |:::..|..|..||.......||.:.:|        :.|..     .||.|:......|.|.| 
Human  1931 LSVALSPDGDRVAVGYRADGIRIYKISSG--------SQGAQGQALDVAVSALAWLSPKVLVSG- 1986

  Fly  1173 KITFYSFRNEELYVNPYSRHPRRKRSLKRHAQAQRSPSTTLPPITCFDLSRDSQQMAIAS----- 1232
                    .|:..:..::......:||...::.|:       |:  ..|:...:.:|.||     
Human  1987 --------AEDGSLQGWALKECSLQSLWLLSRFQK-------PV--LGLATSQELLASASEDFTV 2034

  Fly  1233 ---GRHVHLMRINTPEYQC--TLEGHTAGVSCLKFAPNGEFLATGSEDRLVHIWNLALGE---IC 1289
               .|.:........::.|  .|.||...|||..|:.:|..||||..||.:..|::...:   :.
Human  2035 QLWPRQLLTRPHKAEDFPCGTELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLI 2099

  Fly  1290 NSFKG-HTAPVVKVVVLMDSLRVISTDRDSMLLVWMAHSGNLLQTIQGPYKSLS-VTNNMRFAVS 1352
            :||.. |...|.......|:| :||...|..:.:|...||..|....|...::| |.......||
Human  2100 HSFPACHRDWVTGCAWTKDNL-LISCSSDGSVGLWDPESGQRLGQFLGHQSAVSAVAAVEEHVVS 2163

  Fly  1353 TNGDNTLKIWSLTQEDEKYSV-SHSDEIT----CFEISA-----DSVHIISGSRDMSLKVWQATG 1407
            .:.|.|||:|. .|..|..|: :||..|:    ..|..|     ..:.:::...|.:.::|....
Human  2164 VSRDGTLKVWD-HQGVELTSIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLDGATRLWHPLL 2227

  Fly  1408 GKLSQVLVGHSDAVTCVAVSVTNKTQVLSGSKDMNLILWDLLTGEEVHTLAGHLGPVIGVKVSAD 1472
            ...:..|:|||..|...|||.|:.. :|:.|:|.::.||.:....:...:......|..|..:.|
Human  2228 VCQTHTLLGHSGPVRAAAVSETSGL-MLTASEDGSVRLWQVPKEADDTCIPRSSAAVTAVAWAPD 2291

  Fly  1473 GSTAVSGSDDKTLIVWETKRGLALTSLQMHV-------PFTHF---------------------- 1508
            ||.||||:....||:|:..:.:|......|:       ..|.|                      
Human  2292 GSMAVSGNQAGELILWQEAKAVATAQAPGHIGALIWSSAHTFFVLSADEKISEWQVKLRKGSAPG 2356

  Fly  1509 DISLEVSRVLVQ-----------------LVDSYNLPVICLH--NTPAQ----YVKLPTYSGPSK 1550
            ::||.::|:|.:                 ::...:|.::|:.  :.|::    |.:.|......|
Human  2357 NLSLHLNRILQEDLGVLTSLDWAPDGHFLILAKADLKLLCMKPGDAPSEIWSSYTENPMILSTHK 2421

  Fly  1551 D--VEDLRPQGPKRQMKRLLKKEVSLDTYTWQKKYGHLTSSVMMAQVDERLKRRFSVSASMEEIS 1613
            :  :..|:|:.|            .:.::..||:.|         :.:|||  .|.:  ::|..|
Human  2422 EYGIFVLQPKDP------------GVLSFLRQKESG---------EFEERL--NFDI--NLENPS 2461

  Fly  1614 KIAETKTGASQANLGPEQAALAQSQHFDQLEALWN--KRSPPRRRHNAGL-SRQTSLVEDRLESS 1675
            :   |....:||....|.:.|..|.  |.:  |||  |.||........: .::.:..|.:...:
Human  2462 R---TLISITQAKPESESSFLCASS--DGI--LWNLAKCSPEGEWTTGNMWQKKANTPETQTPGT 2519

  Fly  1676 DDDEYQDERAGMLS-ASYDN 1694
            |....::..|.|.| ||.|:
Human  2520 DPSTCRESDASMDSDASMDS 2539

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG30116NP_725799.1 AAA_16 359..505 CDD:289934 35/166 (21%)
WD40 repeat 901..937 CDD:293791 7/40 (18%)
WD40 933..1282 CDD:238121 84/421 (20%)
WD40 repeat 942..982 CDD:293791 11/41 (27%)
WD40 repeat 988..1024 CDD:293791 6/35 (17%)
WD40 1022..1484 CDD:225201 120/547 (22%)
WD40 repeat 1029..1064 CDD:293791 6/50 (12%)
WD40 repeat 1071..1106 CDD:293791 11/62 (18%)
WD40 repeat 1112..1147 CDD:293791 8/39 (21%)
WD40 repeat 1216..1252 CDD:293791 7/45 (16%)
WD40 1248..1502 CDD:238121 76/270 (28%)
WD40 repeat 1258..1294 CDD:293791 13/38 (34%)
WD40 repeat 1299..1335 CDD:293791 10/35 (29%)
WD40 repeat 1340..1374 CDD:293791 12/35 (34%)
WD40 repeat 1379..1415 CDD:293791 5/44 (11%)
WD40 repeat 1421..1458 CDD:293791 10/36 (28%)
WD40 repeat 1464..1488 CDD:293791 11/23 (48%)
TEP1NP_009041.2 TEP1 N-terminal 1 1..30
TEP1_N 1..29 CDD:283129
TEP1 N-terminal 2 31..60
TEP1_N 31..59 CDD:283129
TEP1 N-terminal 3 61..90
TEP1_N 61..89 CDD:283129
TEP1 N-terminal 4 91..120
TEP1_N 91..119 CDD:283129
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 193..214
TROVE 226..676 CDD:283406
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 383..402
DUF4062 908..1008 CDD:290011 26/170 (15%)
NACHT 1162..1337 CDD:283404 40/198 (20%)
WD 1 1411..1448 9/56 (16%)
WD 2 1674..1713 7/38 (18%)
WD40 1680..1955 CDD:295369 57/298 (19%)
WD40 <1680..1824 CDD:225201 31/154 (20%)
WD40 repeat 1680..1716 CDD:293791 7/39 (18%)
WD 3 1716..1754 12/41 (29%)
WD40 repeat 1722..1757 CDD:293791 11/41 (27%)
WD 4 1757..1796 9/38 (24%)
WD40 repeat 1762..1801 CDD:293791 8/38 (21%)
WD 5 1798..1837 3/38 (8%)
WD40 1799..2190 CDD:225201 91/431 (21%)
WD40 repeat 1804..1840 CDD:293791 3/35 (9%)
WD 6 1840..1879 9/47 (19%)
WD40 repeat 1845..1881 CDD:293791 8/44 (18%)
WD 7 1882..1921 8/42 (19%)
WD40 repeat 1888..1923 CDD:293791 10/38 (26%)
WD 8 1925..1964 9/46 (20%)
WD 9 1967..2005 7/46 (15%)
WD40 1972..2308 CDD:238121 89/356 (25%)
WD40 repeat 1972..2013 CDD:293791 8/49 (16%)
WD 10 2008..2047 7/47 (15%)
WD40 repeat 2016..2059 CDD:293791 7/42 (17%)
WD40 2022..2391 CDD:225201 87/371 (23%)
WD 11 2059..2098 14/38 (37%)
WD40 repeat 2064..2103 CDD:293791 13/38 (34%)
WD 12 2105..2143 11/38 (29%)
WD40 repeat 2111..2145 CDD:293791 9/34 (26%)
WD 13 2146..2183 12/37 (32%)
WD40 repeat 2151..2235 CDD:293791 19/84 (23%)
WD 14 2185..2233 7/47 (15%)
WD40 2231..>2391 CDD:295369 34/160 (21%)
WD 15 2236..2275 13/39 (33%)
WD40 repeat 2241..2280 CDD:293791 10/39 (26%)
WD 16 2278..2317 13/38 (34%)
WD40 repeat 2283..2307 CDD:293791 11/23 (48%)
WD 17 2319..2355 3/35 (9%)
WD40 repeat 2326..2359 CDD:293791 2/32 (6%)
WD 18 2368..2417 5/48 (10%)
WD40 repeat 2372..2418 CDD:293791 5/45 (11%)
WD 19 2459..2500 14/47 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2506..2551 8/34 (24%)
WD 20 2553..2590
WD 21 2592..2626
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4155
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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