DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30116 and Wdr7

DIOPT Version :9

Sequence 1:	NP_725799.1	Gene:	CG30116 / 37126	FlyBaseID:	FBgn0028496	Length:	1922	Species:	Drosophila melanogaster
Sequence 2:	NP_076465.1	Gene:	Wdr7 / 66031	RGDID:	619836	Length:	1488	Species:	Rattus norvegicus

Alignment Length:	1263	Identity:	228/1263 - (18%)
Similarity:	404/1263 - (31%)	Gaps:	374/1263 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   873 LLVPLTGW-LPAPLPSQIRTMTVSGTGCIRAVWLAPSKQHLILATSSGDVQQWHIMSNSLD---- 932
            |::|:..| ..||            |.||.::.|......::.....|.:..|. :|..|:
  Rat     6 LVLPIVLWGRKAP------------THCISSILLTDDGGTIVTGCHDGQICLWD-LSEELEVNPR 57

  Fly   933 HIFKGHTAAVTCLLVAPQS-DSELLLTGSEDATVLVW----------------HVGL-------- 972
            .:..|||||:|||..|..| |.:..::.|.:..:.:|                |.|:
  Rat    58 ALLFGHTAAITCLSKACASGDKQYTVSASANGEMCLWDVNDGRCIEFTKLACTHTGIQFYQFSVG 122

  Fly   973 --RERRAHIKNAHTAPITGVAAGANNTLI-----ISSSEDASIAITDLASGKLRHRITHHRGPVS 1030
              ||.|. :.:.|...|..|.|.:...|.     ||....:|::|           |..||....
  Rat   123 NQREGRL-LCHGHYPEILVVDATSLEVLYSLVSKISPDWISSMSI-----------IRSHRTQED 175

  Fly  1031 GIVVAGACDVLISGGLDRTICVWDLDNFTLLNTMQMTSAVLRIDISWNSVFLLALCEDNALYVRT 1095
            .:|......:|         .||.:.  :.::.:|.|..:...             |...:|.:
  Rat   176 TVVALSVTGIL---------KVWIVT--SEISGLQDTEPIFEE-------------ESKPIYCQ- 215

  Fly  1096 LATGKELHTLKGHKSKIRSISIGKDSQRCVVGCDDTRALIYDMHAGKLVRSLPPNPGPVTAVHAM 1160
                           ..:|:|....:||.::........::|.....|:.|.|...|     ...
  Rat   216 ---------------NCQSLSFCAFTQRSLLVVCSKYWRVFDAGDYSLLCSGPSEDG-----QTW 260

  Fly  1161 DNDDFLVTVGGNKITFYSFRNEE-LYVNPYSRHPRRKRSLKRHAQAQRSPSTTLPPITCFDLSRD 1224
            ...||   |..:|:..::...:. :|..|.|..|   .|....:...::....:||:....|.:.
  Rat   261 TGGDF---VSADKVIIWTENGQSYIYKLPASCLP---ASDSFRSDVGKAVENLIPPVQHSLLDQK 319

  Fly  1225 SQQMAIASGRHVHLMRINTPEYQCTLEGHTAGVSCLKFAPNGEFLATGSEDRLVHIWNLA----- 1284
            .:::.|..       .:....|.|....|             :.|..|.....:.|||:|
  Rat   320 DRELVICP-------PVTRFFYGCKEYLH-------------KLLIQGDSSGRLSIWNIADIADK 364

  Fly  1285 --------------LGEICNSFKGHTAPVV-KVVVLMDSL---------------RVISTDRDSM 1319
                          |.:..:..|...|.:: ::.|:.:|.               |::....|..
  Rat   365 QEANEGLKTTTCISLQDAFDKLKPCPAGIIDQLSVIPNSNEPLKVTASVYIPAHGRLVCGREDGS 429

  Fly  1320 LLVWMAHSGNLLQTIQG---------PYKSLSVTNNMRFAVSTNGDNTLKIWSLTQEDEKYSVSH 1375
            :::..|....::|.:||         |:::|.                               .|
  Rat   430 IIIVPATQTAIVQLLQGEHMLRRGWPPHRTLR-------------------------------GH 463

  Fly  1376 SDEITCF----EISA--DSVHIISGSRDMSLKVWQATGGKLSQVLVGHSDAVTCVAVSVTN---K 1431
            .:::||.    ::||  |..::|||..|.|:.:|....|::..:...|...:|.:.|...|   :
  Rat   464 RNKVTCLLYPHQVSARYDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQLLVPPENCSAR 528

  Fly  1432 TQ--VLSGSKDMNLILWDLLTGEEVHTLAGHLGPVIGVKVSADGSTAVSGSDDKTLIVWETKRGL 1494
            .|  |.|.:.|.::.|..|...:.:...:.||.|:..:|........|.|..|.::.||:...|
  Rat   529 VQHCVCSVASDHSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVVGCTDGSVCVWQMDTG- 592

  Fly  1495 ALTSLQMHVPFTHFDISLEVSRVLVQLVDSYNLPVICLHNTPAQ----------YVKLPT----- 1544
            ||....|.:  |..:|.......:...|||.:.|.:.|.....:          :.||.|
  Rat   593 ALDRCAMGI--TAVEILNACDEAVPAAVDSLSHPAVNLKQAMTRRSLAALKNMAHHKLQTLATNL 655

  Fly  1545 YSGPSKDVEDLRPQGPKRQMKRLLKKEVSLDTYTWQKKYGHLT-----------SSVMMAQVDER 1598
            .:..:.|..:|    ||.....|:.:.:..          :||           .::::..:.|.
  Rat   656 LASEASDKGNL----PKYSHNSLMVQAIKT----------NLTDPDIHVLFFDVEALIIQLLTEE 706

  Fly  1599 LKRRFSVSASMEEISKIAETKTGASQANLGPEQAALAQ----------SQHF-----DQLEALWN 1648
            ..|..:...|.|.:.|.:.:.........|...|.|.|          .:|.     |:.|.:..
  Rat   707 ASRPNTALISPENLQKASGSSDKGGSFLTGKRAAVLFQQVKETIKENIKEHLLDEEEDEEEVMRQ 771

  Fly  1649 KRSPPRRRHNAGLSRQTSLVEDRLESSDD----------------DEYQDERAGML----SASYD 1693
            :|......:.|..|:..:|:|..|.....                ||...:|.|||    :.|:.
  Rat   772 RREESDPEYRASKSKPLTLLEYNLTMDTAKLFMSCLHAWGLNEVLDEVCLDRLGMLKPHCTVSFG 836

  Fly  1694 NI----HHLARLPG--------LRSLHDAWK----TNSL----RVPSRSARTKFYVS-------- 1730
            .:    |....|||        |::..:|.:    |.|:    ...||:..|:..:|
  Rat   837 LLSRGGHMSLMLPGYNQAAGKLLQAKAEAGRKGPATESVGKGTYTVSRAVTTQHLLSIISLANTL 901

  Fly  1731 -----------------TPPPQNSQNSSSLRLDSH------VPGQFTDGVVAPDLVRDLLSVPPT 1772
                             |.||:......|...||.      |.||... ..||...|.......:
  Rat   902 MSMTNATFIGDHMKKGPTRPPRPGTPDLSKARDSPPASSNIVQGQIKQ-AAAPVSARSAADHSGS 965

  Fly  1773 VESPQRISLRQLLH--WPSLKSRIWRRQRNCQSLQPNIRLNPPERLRPTPII--VVENYDVR--R 1831
            ..:...:....|::  |..|.:      .:|..|...:.|.   :.|| |::  :...:..|  .
  Rat   966 ASASPALRTCFLVNEGWSQLAA------MHCVMLPDLLGLG---KFRP-PLLEMLARRWQDRCLE 1020

  Fly  1832 VQQLRTDLILHPQTSRASVGHIEVAGSEHLLAKKANYW-QRRWHLLR-HKAASTTTTTTSRSESS 1894
            |::....|:|      |.:..||.||.:..:...|.|. |...|::. ...|....|..:..::|
  Rat  1021 VREAAQALLL------AELRRIEQAGRKETIDTWAPYLPQYMDHVISPGVTAEAMQTMAAAPDAS 1079

  Fly  1895 HPHRDSMNSHSNNSTPDPTANCNDCVAQ 1922
            .|.........:....|.|..|...|.|
  Rat  1080 GPEAKVQEEEHDLVDDDITTGCLSSVPQ 1107

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30116	NP_725799.1	AAA_16	359..505	CDD:289934
		WD40 repeat	901..937	CDD:293791	5/39 (13%)
		WD40	933..1282	CDD:238121	66/381 (17%)
		WD40 repeat	942..982	CDD:293791	13/66 (20%)
		WD40 repeat	988..1024	CDD:293791	8/40 (20%)
		WD40	1022..1484	CDD:225201	85/517 (16%)
		WD40 repeat	1029..1064	CDD:293791	4/34 (12%)
		WD40 repeat	1071..1106	CDD:293791	2/34 (6%)
		WD40 repeat	1112..1147	CDD:293791	6/34 (18%)
		WD40 repeat	1216..1252	CDD:293791	4/35 (11%)
		WD40	1248..1502	CDD:238121	56/308 (18%)
		WD40 repeat	1258..1294	CDD:293791	7/54 (13%)
		WD40 repeat	1299..1335	CDD:293791	6/51 (12%)
		WD40 repeat	1340..1374	CDD:293791	1/33 (3%)
		WD40 repeat	1379..1415	CDD:293791	12/41 (29%)
		WD40 repeat	1421..1458	CDD:293791	9/41 (22%)
		WD40 repeat	1464..1488	CDD:293791	4/23 (17%)
Wdr7	NP_076465.1	WD 1	17..56		10/51 (20%)
		WD40	<19..199	CDD:225201	42/203 (21%)
		WD40	<19..102	CDD:295369	21/83 (25%)
		WD40 repeat	22..62	CDD:293791	6/40 (15%)
		WD 2	62..104		13/41 (32%)
		WD40 repeat	68..109	CDD:293791	8/40 (20%)
		WD40 repeat	114..153	CDD:293791	8/39 (21%)
		WD 3	156..199		11/64 (17%)
		WD40 repeat	162..208	CDD:293791	11/80 (14%)
		WD 4	324..366		10/61 (16%)
		WD40	341..>592	CDD:225201	52/294 (18%)
		WD40 repeat	393..461	CDD:293791	9/67 (13%)
		WD 5	404..443		3/38 (8%)
		WD40	407..>594	CDD:295369	41/218 (19%)
		WD 6	462..507		13/44 (30%)
		WD40 repeat	468..522	CDD:293791	15/53 (28%)
		WD 7	558..597		12/39 (31%)
		WD40 repeat	563..589	CDD:293791	6/25 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	761..781		3/19 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	911..947		8/35 (23%)
		WD 8	1349..1388
		WD40 repeat	1354..1390	CDD:293791
		WD40	<1355..1424	CDD:295369
		WD40	<1363..>1482	CDD:225201
		WD 9	1390..1430
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4155
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900