DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG30116 and Tep1

DIOPT Version :10

Sequence 1:NP_725799.1 Gene:CG30116 / 37126 FlyBaseID:FBgn0028496 Length:1922 Species:Drosophila melanogaster
Sequence 2:NP_072113.1 Gene:Tep1 / 64523 RGDID:3869 Length:2629 Species:Rattus norvegicus


Alignment Length:1831 Identity:354/1831 - (19%)
Similarity:592/1831 - (32%) Gaps:556/1831 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 IKIYVASLKQEFNQERRMLLELVGPELQSLYDDRQIELEFVDMHFGTGDLEVHQLERDPYLIHDY 93
            |:::::|..::.:.||.:|:..|.|.||:.....:|.|..:|:.:|..:.|..:           
  Rat   912 IRLFISSTFRDMHGERDLLMRSVLPALQARAFPHRISLHAIDLRWGITEEETRR----------- 965

  Fly    94 LHEIDTCHAHTK-SVFFMVLVGDGIGRQLLPTKIDEDIFSAVLADQQTSADHEAMLVKWYERDAS 157
            ..:::.|....: |..|:.::|...|  ..|...|             ..||...  .|.:|..|
  Rat   966 NRQLEVCLGEVENSQLFVGILGSRYG--YTPPSYD-------------LPDHPHF--HWTQRYPS 1013

  Fly   158 QTQRQLKQDYRLMNVDAWLAESQRMQSFLEQAFQSLLQGSGASGRSPDFMERVQLLRRTQIEREV 222
              .|.:.:    |.|..:|...||.    |.:.|:|:.     .|.|.|:..|..:.:.....|.
  Rat  1014 --GRSVTE----MEVMQFLNRGQRS----EPSDQALIY-----FRDPGFLSSVPDVWKPDFISES 1063

  Fly   223 SQAMALTSE--KILAVFRE---RAAQCSKGDVEAAERLRKIKDELTMNLSTDNHTTL----VVPG 278
            .:|....||  :.|...:|   |...|..|.|.|........:|....:..|..:.:    :.||
  Rat  1064 EEAAHRVSELKRFLQEQKEVTCRRYSCEWGGVAAGRPYTGGLEEFGQLVLQDVWSVIQKRYLQPG 1128

  Fly   279 SAASEAIDPDNEDHESYLSKFKNKVTDKLRLLIEA---HITNDPDVIKGR--KKTVQEIFHEHAT 338
            :...:......||                  ||:|   .:.:.|...:.|  :.|||::...|. 
  Rat  1129 AQLEQPGSISEED------------------LIQASFQQLKSPPSPARPRLLQDTVQQLMLPHG- 1174

  Fly   339 HLRILREHTDSDALVESRVPQQLRQNLMANFRNGSRHAPYFLCGADGSGKSAILCHLYGQVGSWF 403
                                   |.:|              :.|..|.||:|.|..|...:    
  Rat  1175 -----------------------RLSL--------------VIGQAGQGKTAFLASLVSAL---- 1198

  Fly   404 GSTRVHRV-----------IRFAKATPRSAYNLELLRVICQQI---------------SIIFNIP 442
                  :|           ..|:.|.|.......|||.:|..:               .:::.:.
  Rat  1199 ------KVPDQPNVAPFVFFHFSAARPDQCLAFNLLRRLCTHLHQKLGEPSALPSTYRGLVWELQ 1257

  Fly   443 EGYLPKDASFDPLYINTWFQNLLRRVEDMGNDVLFLFIDDLHLLNPLDCDIVTALSWLPTSLPWN 507
            :..|.|.|.        |.|         ....|.|.||....|...:..:::  .|:|.|||..
  Rat  1258 QKLLLKSAQ--------WLQ---------PGQTLVLIIDGADKLVDHNGQLIS--DWIPKSLPRR 1303

  Fly   508 VQIICS---------------STTPVEQLKFTPMQRDRFKSIEYQFDLNMGDYATKLKIPPQCIP 557
            |.::.|               |...|......|..|.:....|      :..|..:|:..    |
  Rat  1304 VHLVLSVSSDSGLGETLQQSQSAYVVALGSLVPSSRAQLVREE------LALYGKRLEES----P 1358

  Fly   558 GDVSFALYVEQQFDQLERHYGRQAVGDLASYITCSEYGLSETELLELLMP--TDDPESLIETKNG 620
            .:....|.:.:|...|..:.  ..|.|.....|..|........|...:|  .....|.:|.::|
  Rat  1359 FNNQMRLLLAKQGSSLPLYL--HLVTDYLRLFTLYEQVSERLRTLPATLPLLLQHILSTLEQEHG 1421

  Fly   621 H-------------FSFATFKKIHREMDLLLLLHDKIMSGKVLIQWRHNYCAS-------VAKRR 665
            |             .|..|..::|..:...|.|..:..|      |.....||       :|...
  Rat  1422 HNVLPQALTALEVTHSGLTVDQLHAVLSTWLTLPKETKS------WEEAVAASHSGNLYPLAPFA 1480

  Fly   666 YMDVQRTRSLHCELANLFFPQDEDESTLENESNR---SESKSVISLKDRDREKDSLSAVSAVSAG 727
            |: ||..|||            ..|..:|....|   |:.....::|.|..::..|...:.|...
  Rat  1481 YL-VQSLRSL------------LGEGPVERPGARLCLSDGPLRTAVKRRYGKRLGLEKTAHVLIA 1532

  Fly   728 RKSSSTHHNDDTSTFYN--PIA-ADVSYSMRHVEESWHHLMRSDDTTRFKQIAVCNFDFLLAAVQ 789
            .........|.:.||.:  |.| .|:.|   |:.:|.:|.:.:...|....:|.           
  Rat  1533 AHLWKMCDPDASGTFRSCPPEALKDLPY---HLLQSGNHGLLAKFLTNLHVVAA----------- 1583

  Fly   790 TVSISYLRCLIEHVRCY----------ILDRDIELIYYTIRKSSDVLTRDPMQLGSQLISWLRPI 844
            .:.:..:..|:|....|          :.:.|:.:.:..:::.:.:||:.|:.|..|..|  :| 
  Rat  1584 YLEVGLVPDLLEAYELYASSKPEVNQKLPEADVAVFHNFLKQQASLLTQYPLLLLQQAAS--QP- 1645

  Fly   845 SEHDDDDNSLLSMTVRSATAWCDGYAVPLLVP------LTGWL--PAPLPSQIRTMTVSGTGCIR 901
                           ..:...|.   .|||..      :..|:  |..|..| :::::..:....
  Rat  1646 ---------------EESPVCCQ---APLLTQRWHNQCILKWINKPQTLKGQ-QSLSLPISSSPT 1691

  Fly   902 AVWLAPSKQHLILATSSGDV--------QQWHIMSNSLDHIFKGHTAAVTCLLVAPQSDSELLLT 958
            ||..:|:.|...:.|:.|.:        |:...:.:..|.|..          .|..||:.|.||
  Rat  1692 AVAFSPNGQRAAVGTAGGTIYLLNLRTWQEEKALVSGCDGISS----------FAFLSDTALFLT 1746

  Fly   959 GSEDATVLVWHVGLRERRAH-----IKNAHTAPITGVAAGANNTLIISSSEDASIAITDLASGKL 1018
             :.|..:.:|.:      .|     ...||...|||.....:..|:.:......:.:.|...|:|
  Rat  1747 -TFDGLLELWDL------QHGCWVFQTKAHQYQITGCCLSPDRRLLATVCLGGYVKLWDTVQGQL 1804

  Fly  1019 RHRITHHR----------------GPVSGIVVAGACD-------------------------VLI 1042
            ..:.||.:                |..||||.....|                         |:.
  Rat  1805 AFQYTHPKSLNCITFHPEGQVVATGNWSGIVTFFQADGLKVTKELGGPGPSVRTLAFSAPGKVVA 1869

  Fly  1043 SGGLDRTICVWDLDNFTLLNTMQMTSAVLRIDISWNSVFLLALCEDNALYVRTL----ATGKELH 1103
            .|.:|.|:.:|                      :|.....||........|.|:    |.|:.|.
  Rat  1870 LGRIDGTVELW----------------------AWQEGTRLAAFPAQCGGVSTVLFLHAGGRFLT 1912

  Fly  1104 TLKGHKSKIRSISIGKDSQRCVVGCDDTRALIYDMHAGKLVRSLPPNPGPVTAVHAMDNDDFLVT 1168
            ..:..|:::.|..:|:..     ||           .|.|..|      |..:| |::.|...|.
  Rat  1913 AGEDGKAQLWSGFLGRPR-----GC-----------LGSLYLS------PALSV-ALNPDGDQVA 1954

  Fly  1169 VGGNKITFYSFRNEELYVNPYSRHPRRKRSLKRHAQAQR-----SPSTTLPPITCFDLSRDSQQM 1228
            ||        :|.:.:.:...|..|       :.||.|.     |....|.|......:.|    
  Rat  1955 VG--------YRGDGIKIYRISSGP-------QEAQCQELNVAVSALVWLSPSVLVSGAED---- 2000

  Fly  1229 AIASGRHVHLMRINTPEYQCTLEGHTAGVSCLK----FAPNGEFLATGSEDRLVHIWNL------ 1283
               ...|..::|.|      :|:.......|.|    .|.:.||||:.|||..|.:|..      
  Rat  2001 ---GSLHGWMLRRN------SLQSLWLSSVCQKPVLGLAASQEFLASASEDFTVRLWPRQLLTQP 2056

  Fly  1284 -ALGEI-CNS-FKGHTAPVVKVVVLMDSLRVISTDRDSMLLVW---MAHSGNLLQTIQGPYKSLS 1342
             |:.|: |.: .:||..||.......|...:.:..||..||.|   :|.:..|:.|....::.. 
  Rat  2057 HAVEELPCAAELRGHEGPVCCCSFSPDGRILATAGRDRNLLCWDVKVAQAPLLIHTFSSCHRDW- 2120

  Fly  1343 VT----NNMRFAVSTNGDNTLKIWS--LTQEDEKYSVSHSDEITCFEISADSVHIISGSRDMSLK 1401
            :|    ......:|.:.|.::.:|:  ..|:..::. .|...::.  :.|...||:|.|||.:||
  Rat  2121 ITGCTWTKDNILISCSSDGSVGLWNPEAGQQLGQFP-GHQSAVSA--VVAVEEHIVSVSRDGTLK 2182

  Fly  1402 VWQATGGKLSQVLVGHSDAVTCVAVSVTNKTQVLSGSKDMNLI--------LWDLLTGEEVHTLA 1458
            ||...|.:|:.: ..||..::..|.::..:.....||:.|.:.        ||..|...::|||.
  Rat  2183 VWDRQGVELTSI-PAHSGPISQCAAALEPRPAGQPGSELMVVTVGLDGATKLWHPLLVCQIHTLQ 2246

  Fly  1459 GHLGPVIGVKVS-----------------------------------------ADGSTAVSGSDD 1482
            ||.|||.....|                                         .|||..|||::.
  Rat  2247 GHSGPVTAAAASEASGLLLTSDNSSVRLWQIPKEADDTCKPRSSAVITAVAWAPDGSLVVSGNEA 2311

  Fly  1483 KTLIVWETKRGLALTSLQMHV---------PFTHFDISLEVSRVLVQLVDSYNLPVICLHNTPAQ 1538
            ..|.:|:..:.:|.......|         .|.....:..||...|:|..........|:.....
  Rat  2312 GELTLWQKAQAVATARAPGRVSDLIWCSANAFFVLSANENVSEWQVELRKGSTCTNFRLYLKRVL 2376

  Fly  1539 YVKLPTYSGPSKDVEDLRPQGPKRQMKRLLKKEVSLDTYTWQKKYGHLTSSVMMAQVDERLKRRF 1603
            ...|...:|.:     |.|.|   |...|:|::|.|    .|.|.|...||:.         ||:
  Rat  2377 QEDLGVLTGMA-----LAPDG---QSLILMKEDVEL----LQMKPGSTPSSIC---------RRY 2420

  Fly  1604 SVSASMEEISK 1614
            :|.:|:...||
  Rat  2421 AVHSSILCTSK 2431

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG30116NP_725799.1 WD40 <897..1057 CDD:441893 40/213 (19%)
WD40 repeat 901..937 CDD:293791 9/43 (21%)
WD40 repeat 942..982 CDD:293791 9/44 (20%)
WD40 repeat 988..1024 CDD:293791 6/35 (17%)
WD40 991..1491 CDD:441893 127/620 (20%)
WD40 repeat 1029..1064 CDD:293791 10/59 (17%)
WD40 repeat 1071..1106 CDD:293791 8/38 (21%)
WD40 repeat 1112..1147 CDD:293791 6/34 (18%)
WD40 repeat 1216..1252 CDD:293791 5/35 (14%)
WD40 repeat 1258..1294 CDD:293791 15/48 (31%)
WD40 repeat 1299..1335 CDD:293791 10/38 (26%)
WD40 repeat 1340..1374 CDD:293791 5/39 (13%)
WD40 repeat 1379..1415 CDD:293791 13/35 (37%)
WD40 repeat 1421..1458 CDD:293791 9/44 (20%)
WD40 repeat 1464..1488 CDD:293791 9/64 (14%)
Tep1NP_072113.1 TEP1 N-terminal 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00575, ECO:0000269|PubMed:10864046 1..30
TEP1_N 1..29 CDD:428450
TEP1 N-terminal 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00575, ECO:0000269|PubMed:10864046 31..60
TEP1_N 31..59 CDD:428450
TEP1 N-terminal 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00575, ECO:0000269|PubMed:10864046 61..90
TEP1_N 61..89 CDD:428450
TEP1 N-terminal 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00575, ECO:0000269|PubMed:10864046 91..120
TEP1_N 91..119 CDD:428450
TROVE 234..689 CDD:461724
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 390..416
DUF5920 700..900 CDD:466045
DUF4062 913..1021 CDD:463823 26/141 (18%)
NACHT 1175..1350 CDD:428606 39/223 (17%)
WD 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:10864046 1424..1461 6/42 (14%)
WD40 <1674..1923 CDD:441893 51/288 (18%)
WD 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:10864046 1685..1724 7/38 (18%)
WD40 repeat 1691..1727 CDD:293791 7/35 (20%)
WD 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:10864046 1727..1765 11/54 (20%)
WD40 repeat 1733..1768 CDD:293791 9/51 (18%)
WD 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:10864046 1768..1807 9/38 (24%)
WD40 repeat 1773..1812 CDD:293791 9/38 (24%)
WD 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:10864046 1809..1848 8/38 (21%)
WD40 repeat 1815..1851 CDD:293791 6/35 (17%)
WD 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:10864046 1851..1890 7/60 (12%)
WD40 repeat 1856..1896 CDD:293791 8/61 (13%)
WD40 1860..2318 CDD:441893 114/535 (21%)
WD 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:10864046 1893..1934 10/56 (18%)
WD 8. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:10864046 1936..1975 12/60 (20%)
WD40 repeat 1942..2000 CDD:293791 15/73 (21%)
WD 9. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:10864046 1978..2016 8/50 (16%)
WD 10. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:10864046 2019..2058 12/38 (32%)
WD 11. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:10864046 2070..2109 11/38 (29%)
WD40 repeat 2076..2113 CDD:293791 8/36 (22%)
WD 12. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:10864046 2116..2154 5/38 (13%)
WD40 repeat 2121..2156 CDD:293791 5/34 (15%)
WD 13. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:10864046 2157..2194 14/38 (37%)
WD40 2164..2586 CDD:441893 68/292 (23%)
WD40 repeat 2166..2195 CDD:293791 13/29 (45%)
WD 14. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:10864046 2200..2244 7/43 (16%)
WD40 repeat 2201..2246 CDD:293791 9/44 (20%)
WD 15. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:10864046 2247..2285 6/37 (16%)
WD 16. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:10864046 2288..2327 9/38 (24%)
WD40 repeat 2293..2317 CDD:293791 7/23 (30%)
WD 17. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:10864046 2329..2365 6/35 (17%)
WD40 repeat 2332..2355 CDD:293791 4/22 (18%)
WD 18. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:10864046 2378..2427 19/69 (28%)
WD 19. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:10864046 2470..2510
WD 20. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:10864046 2555..2592
WD 21. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:10864046 2594..2628
Blue background indicates that the domain is not in the aligned region.

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