DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30116 and LOC362863

DIOPT Version :9

Sequence 1:	NP_725799.1	Gene:	CG30116 / 37126	FlyBaseID:	FBgn0028496	Length:	1922	Species:	Drosophila melanogaster
Sequence 2:	NP_001164076.1	Gene:	LOC362863 / 362863	RGDID:	1302940	Length:	1312	Species:	Rattus norvegicus

Alignment Length:	600	Identity:	123/600 - (20%)
Similarity:	214/600 - (35%)	Gaps:	149/600 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 IDESVLNALRGVTSAHTRLPKPLLIKIYVASLKQEFNQERRMLLELVGPELQSLYDDRQIELEFV 69
            |:|::..|.|..:....:..||  |:.|:.| ..:|..||..|.:.:.|:|......|....:.|
  Rat     2 IEEAIETAQRYNSQPILKRQKP--IRPYICS-TIDFQDERDFLAKTIFPQLNDFCSSRGTYFKAV 63

  Fly    70 DMHFGTGDLEVHQ-LERDPYLIHDYLHE---------IDTCHAHTKSVFFMVLVGDGIGRQLLPT 124
            |:.:..  |:.|: ...:.:..:..||.         ::.|..     ||:.|:|...| ..||
  Rat    64 DLRWSA--LKAHKSFTNNQFRQYSCLHSQHLKLCLDYVNRCFP-----FFICLLGQTYG-DFLP- 119

  Fly   125 KIDEDIFSAVLADQQTSADHEAMLV------KWYER--DASQTQRQLKQDYRLMNVDAWLAESQR 181
            .....:.|.|...:..|...:.:.|      .|..:  :.|.|:.::        :.|...:..:
  Rat   120 DYTPFLLSKVKDLESLSKGEQNLYVAAKNGYPWVLKTPNCSLTEFEI--------IQAAFRKKSQ 176

  Fly   182 MQSFLEQAFQSLLQGSGASGRSPDFMERVQLLRRTQIEREVSQAMALTSEKILAVFRERAAQCSK 246
            .|.|..:...|||:         .|.|..:     :.|.::|....:..:..:.|.:.:|....|
  Rat   177 FQFFYFRTSNSLLR---------TFSEEEE-----EEEEKLSSGYQVDRQGKVKVGKLKAKIIGK 227

  Fly   247 GDVEAAERLRKIKDELTMNLSTDNHTTLVVPGSAASEAIDP-----DNEDHESYLSKFKNKVTDK 306
            |   ...|..:..|||...:..|        .||..|.:.|     :|.|   |...|:|
  Rat   228 G---LPVRFYRDLDELGDMVLKD--------WSAVVEELYPVTMIMENID---YKHSFEN----- 273

  Fly   307 LRLLIEAHITNDPDVI---KGRKKTVQEIFHEHATHLRILREHTDSDALVESRVPQQLRQNLMAN 368
              |..|..:.|...|.   |...:|.:.:.......|.:..:.|.:.|.::|    .||.|.:..
  Rat   274 --LYHEEFVENCKQVFVISKESNRTFEMLERFAIKDLELNSDSTVAGAGLDS----ILRINSLPT 332

  Fly   369 FRNGSRHAPYFLCGADGSGKSAILCHLYGQVGSWFGSTR-----VHRVIRFAKATPRSAYNLELL 428
            .:     :...|||..|.|||.:       :.:|....:     |..|..|..:|..|...:.::
  Rat   333 CK-----SILLLCGERGCGKSTL-------IANWVDDFKSRHPGVLMVPYFVGSTCESCDIMSVM 385

  Fly   429 RVICQQISIIFNIPEGYLPKDASFDPLYINTWFQNLLRRVEDMGNDVLFLFIDDLHL----LNPL 489
            .....::....|.|:  |..|      ::|          || .|.::|..:.::.:    |.|
  Rat   386 HYFIMELQHRANGPQ--LEMD------FLN----------ED-SNVLVFSLLIEVFMAAISLKP- 430

  Fly   490 DCDIV------------------TALSWLPTSLPWNVQIICSSTTPVEQLKFTPMQRDRFKSIEY 536
             |.:|                  ...||||.|||.:.:.|.||.:.....| :...|...|::|.
  Rat   431 -CILVLDGIEELVGIYGISGQKAKDFSWLPRSLPPHCKFILSSVSSSLSCK-SLCARPDVKTVEL 493

  Fly   537 QFDLNMGDYATKLKI 551
            .   ::||..||..|
  Rat   494 N---SLGDEDTKFSI 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30116	NP_725799.1	AAA_16	359..505	CDD:289934	34/172 (20%)
		WD40 repeat	901..937	CDD:293791
		WD40	933..1282	CDD:238121
		WD40 repeat	942..982	CDD:293791
		WD40 repeat	988..1024	CDD:293791
		WD40	1022..1484	CDD:225201
		WD40 repeat	1029..1064	CDD:293791
		WD40 repeat	1071..1106	CDD:293791
		WD40 repeat	1112..1147	CDD:293791
		WD40 repeat	1216..1252	CDD:293791
		WD40	1248..1502	CDD:238121
		WD40 repeat	1258..1294	CDD:293791
		WD40 repeat	1299..1335	CDD:293791
		WD40 repeat	1340..1374	CDD:293791
		WD40 repeat	1379..1415	CDD:293791
		WD40 repeat	1421..1458	CDD:293791
		WD40 repeat	1464..1488	CDD:293791
LOC362863	NP_001164076.1	AAA_22	334..>441	CDD:379165	26/139 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19871
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100