DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30116 and APAF1

DIOPT Version :9

Sequence 1:	NP_725799.1	Gene:	CG30116 / 37126	FlyBaseID:	FBgn0028496	Length:	1922	Species:	Drosophila melanogaster
Sequence 2:	NP_863651.1	Gene:	APAF1 / 317	HGNCID:	576	Length:	1248	Species:	Homo sapiens

Alignment Length:	1465	Identity:	271/1465 - (18%)
Similarity:	466/1465 - (31%)	Gaps:	478/1465 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   212 LLRRTQIEREVSQAMA---LTSEKILAVFRERAAQCSKGDVEAAERLRKIKDELTMNLSTDNHTT 273
            |..|..:|:::..:..   :.|:..|.:..|...:......:.|..|.|      |.|..||.:.
Human    10 LQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIK------MILKKDNDSY 68

  Fly   274 L-----------------------VVPGSAASEAIDPDNEDHESYLSKFKNKVTDKLR-LLIEAH 314
            :                       ||..|:..:::               :.:|..:| :|.|..
Human    69 VSFYNALLHEGYKDLAALLHDGIPVVSSSSGKDSV---------------SGITSYVRTVLCEGG 118

  Fly   315 ITNDPDVIKGRKKTVQEIFHEHATHLR----------------------ILREHTDSDALVESRV 357
            :...|.|...|||.|..| .:..:.|:                      .:|:|    :|:|...
Human   119 VPQRPVVFVTRKKLVNAI-QQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDH----SLLEGCF 178

  Fly   358 P---------QQLRQNLMANFRNGSRHAPYFLCGADGSGKSAILCHLYGQVGSWFGSTRVHRVIR 413
            |         :|.:..|:...:|                    ||....|..|:  |.|:...|.
Human   179 PGGVHWVSVGKQDKSGLLMKLQN--------------------LCTRLDQDESF--SQRLPLNIE 221

  Fly   414 FAK---------ATPRSAYNLE------LLRVICQQISIIFNIPEGYLPKDASFDPLYINTWFQN 463
            .||         ..|||...|:      :|:....|..|:....:..: .|:...|.|:.....:
Human   222 EAKDRLRILMLRKHPRSLLILDDVWDSWVLKAFDSQCQILLTTRDKSV-TDSVMGPKYVVPVESS 285

  Fly   464 LLRRVEDMGNDVLFLFID----DL----HLL------NPLDCDIVTALSWLPTSLP--WNVQIIC 512
            |   .::.|.::|.||::    ||    |.:      :||   :|:.:..|....|  |...:
Human   286 L---GKEKGLEILSLFVNMKKADLPEQAHSIIKECKGSPL---VVSLIGALLRDFPNRWEYYL-- 342

  Fly   513 SSTTPVEQLKFTPMQRDRFKSIEYQFDL--------------NMGDYATKL-------KIPPQ-- 554
                  :||:....:|.| ||..|.::.              ::.||.|.|       |:|.:
Human   343 ------KQLQNKQFKRIR-KSSSYDYEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVL 400

  Fly   555 CIPGDVSFALYVEQQFDQLE-----------------RHYGRQAVGDLASYITCSEYGLSETELL 602
            ||..|:.    .|:..|.|:                 |:|......|..:...||:......:::
Human   401 CILWDME----TEEVEDILQEFVNKSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKII 461

  Fly   603 ELLMPTDDPESLIETKNG---HFSFATF----KKIHREMDLLLLLHDKIMSGKVLIQWRHNYCAS 660
            ........|.:|...:..   .::|..:    .|:|:|:..|:...|.|.:...|:...|.....
Human   462 TQFQRYHQPHTLSPDQEDCMYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEF 526

  Fly   661 VAKRRYMDVQRTRSLHCELANLF---------------FPQDEDESTLENESNRSESKSVISLKD 710
            |..|..:|.:     .|.::..|               ||........|.|::....::.:..|
Human   527 VEYRHILDEK-----DCAVSENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAK- 585

  Fly   711 RDREKDS-------LSAVSAVSAGRKSSSTHHNDDTSTFYNPIAADVSYSMRHVEESWHHLMRSD 768
              :|.|:       ::..:..:..|.....|             .|..|          |...|:
Human   586 --QEVDNGMLYLEWINKKNITNLSRLVVRPH-------------TDAVY----------HACFSE 625

  Fly   769 DTTRFKQIAVCNFDFLLAAVQTVSISYLRCLIEHVRCYILDRDIELIYYTIRKSSDVLTRDPMQL 833
            |..|   ||.|..|..|...:.                                         :.
Human   626 DGQR---IASCGADKTLQVFKA-----------------------------------------ET 646

  Fly   834 GSQLISWLRPISEHDDDDNSLLSMTVRSATAWCDGYAVPLLVPLTGWLPAPLPSQIRTMTVSGTG 898
            |.:|:.    |..|:|:
Human   647 GEKLLE----IKAHEDE------------------------------------------------ 659

  Fly   899 CIRAVWLAPSKQHLILATSSGD--VQQWHIMSNSLDHIFKGHTAAVTCLLVAPQSDSELLLTGSE 961
               .:..|.|.....:||.|.|  |:.|:.|:..|.|.:..|:..|.|......|...||.|||.
Human   660 ---VLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSS 721

  Fly   962 DATVLVWHVGLRERRAHIKNAHTAPITGVAAGANNTLIISSSEDASIAITDLASGKLRHRIT--- 1023
            |..:.:|.:..:|.| :....||..:.......::.|:.|.|.|.::.:.|..|...|..|.
Human   722 DCFLKLWDLNQKECR-NTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQ 785

  Fly  1024 ---HHRGPVSGIVVAGACDVLISGGLDRTICVWDLDNFTLLNTMQMTSAVLRIDISWNSVFLLAL 1085
               :...|...:.|...|            |.|..|...::...:            |.:||..
Human   786 FFLNLEDPQEDMEVIVKC------------CSWSADGARIMVAAK------------NKIFLFD- 825

  Fly  1086 CEDNALYVRTLATGKELHTLKGHKSKIR--------SISIGKDSQRCV-VGCDDTRALIYDMHAG 1141
                   :.|.....|:||  ||.|.|:        .:::...||.|| :...|:|:.:.|..
Human   826 -------IHTSGLLGEIHT--GHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCR-- 879

  Fly  1142 KLVRSLPPNPGPVTAVHAM----DNDDFLVTVGGNKITFYSFRNEELYVNPYSRHPRRKRSLKRH 1202
                      |.::.||.:    |...||.:.....|..:                ..|:..|..
Human   880 ----------GHLSWVHGVMFSPDGSSFLTSSDDQTIRLW----------------ETKKVCKNS 918

  Fly  1203 AQAQRSPSTTLPPITCFDLSRDSQQMAIASGRHVHLMRINTPEYQCTLEGHT--------AGVSC 1259
            |...:..         .|:.....::.:.:..|:..:::        :.|.|        |.|||
Human   919 AVMLKQE---------VDVVFQENEVMVLAVDHIRRLQL--------INGRTGQIDYLTEAQVSC 966

  Fly  1260 LKFAPNGEFLATGSEDRLVHIWNLALGEICNSFKGHTAPVVKVVVLMDSLRVISTDRDSMLLV-- 1322
            ...:|:.:::|.|.|:..:.|..|....|..|...|...|..:....|...:||:..|:.:.|
Human   967 CCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWN 1031

  Fly  1323 WMAHSGNLLQTIQGPYKSLSVTNNMRFAVSTNGDNTLKIWS-LTQEDEKYSVSHSDEITCFEISA 1386
            |.......|:..|...|...:..|.|. :|.:.|.|:|:|: :|...||..|.|...:...:||.
Human  1032 WQLDKCIFLRGHQETVKDFRLLKNSRL-LSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISH 1095

  Fly  1387 DSVHIISGSRDMSLKVWQATGGKLSQVLVGHSDAVTCVAVSVTNKTQVLSGSKDMNLILWDLLTG 1451
            |:....|.|.|.:.|:|..........|.||:..|.|.|.|| :.|.:.:|..:..:.:|::..|
Human  1096 DATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSV-DSTLLATGDDNGEIRIWNVSNG 1159

  Fly  1452 EEVHT--------LAGHLGPVIGVKVSADGSTAVS 1478
            |.:|.        .|.|.|.|..:..|.||...:|
Human  1160 ELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLIS 1194

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30116	NP_725799.1	AAA_16	359..505	CDD:289934	34/174 (20%)
		WD40 repeat	901..937	CDD:293791	11/37 (30%)
		WD40	933..1282	CDD:238121	71/375 (19%)
		WD40 repeat	942..982	CDD:293791	12/39 (31%)
		WD40 repeat	988..1024	CDD:293791	8/41 (20%)
		WD40	1022..1484	CDD:225201	104/495 (21%)
		WD40 repeat	1029..1064	CDD:293791	5/34 (15%)
		WD40 repeat	1071..1106	CDD:293791	7/34 (21%)
		WD40 repeat	1112..1147	CDD:293791	8/43 (19%)
		WD40 repeat	1216..1252	CDD:293791	2/35 (6%)
		WD40	1248..1502	CDD:238121	67/250 (27%)
		WD40 repeat	1258..1294	CDD:293791	10/35 (29%)
		WD40 repeat	1299..1335	CDD:293791	8/37 (22%)
		WD40 repeat	1340..1374	CDD:293791	10/34 (29%)
		WD40 repeat	1379..1415	CDD:293791	8/35 (23%)
		WD40 repeat	1421..1458	CDD:293791	11/44 (25%)
		WD40 repeat	1464..1488	CDD:293791	5/15 (33%)
APAF1	NP_863651.1	CARD_APAF1	7..92	CDD:260034	13/87 (15%)
		NB-ARC	129..374	CDD:395745	54/287 (19%)
		APAF1_C	453..587	CDD:407760	21/141 (15%)
		WD40	607..910	CDD:238121	83/487 (17%)
		WD 1-1	613..652		14/105 (13%)
		WD40 repeat	623..655	CDD:293791	11/79 (14%)
		WD 1-2	655..694		12/89 (13%)
		WD40 repeat	660..697	CDD:293791	11/36 (31%)
		WD 1-3	697..738		13/41 (32%)
		WD40 repeat	703..741	CDD:293791	11/38 (29%)
		WD 1-4	741..780		9/38 (24%)
		WD40 repeat	746..791	CDD:293791	8/44 (18%)
		WD 1-5	796..836		10/71 (14%)
		WD40 repeat	802..870	CDD:293791	19/101 (19%)
		WD 1-6	838..877		10/38 (26%)
		WD 1-7	880..910		7/45 (16%)
		WD40 repeat	885..939	CDD:293791	10/78 (13%)
		Interpropeller linker. /evidence=ECO:0000250	910..921		3/10 (30%)
		WD 2-1	922..958		4/52 (8%)
		WD 2-2	959..998		11/38 (29%)
		WD40	961..1234	CDD:238121	65/236 (28%)
		WD40 repeat	964..990	CDD:293791	8/25 (32%)
		WD 2-3	1001..1040		8/38 (21%)
		WD40 repeat	1006..1030	CDD:293791	5/23 (22%)
		WD 2-4	1042..1080		11/38 (29%)
		WD40 repeat	1047..1082	CDD:293791	11/35 (31%)
		WD 2-5	1083..1122		9/38 (24%)
		WD40 repeat	1089..1124	CDD:293791	8/34 (24%)
		WD 2-6	1125..1164		12/39 (31%)
		WD40 repeat	1130..1172	CDD:293791	11/42 (26%)
		WD 2-7	1175..1212		7/20 (35%)
		WD40 repeat	1180..1213	CDD:293791	5/15 (33%)
		WD 2-8	1213..1248
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4155
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810