DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30116 and Rbcn-3B

DIOPT Version :9

Sequence 1:	NP_725799.1	Gene:	CG30116 / 37126	FlyBaseID:	FBgn0028496	Length:	1922	Species:	Drosophila melanogaster
Sequence 2:	NP_001284797.1	Gene:	Rbcn-3B / 31155	FlyBaseID:	FBgn0023510	Length:	1525	Species:	Drosophila melanogaster

Alignment Length:	1193	Identity:	214/1193 - (17%)
Similarity:	390/1193 - (32%)	Gaps:	439/1193 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   873 LLVPLTGWLP-APLPSQIRTMTVSGTGCIRAVWLAPSKQHLILATSSGDVQQWHIMSNSLDH--- 933
            |:||:..|.| ||            |.||.:|:|:..:..|:.....|.:..|.:...:|..
  Fly     6 LVVPVVLWGPTAP------------THCISSVFLSDDQFTLVTGCYDGQICLWQVEPTTLKMSPR 58

  Fly   934 -IFKGHTAAVTCLLVA---PQSDSELLLTGSEDATVLVWH---------VGLRERRAHIKNAHTA 985
             :..||:|.|.||:.|   |:::  .|::.||:..:..|.         |.|.:....|::.|||
  Fly    59 CLLVGHSAPVLCLVRASLLPENN--FLVSSSENGEMCTWDLTDGKCMEAVKLPQVHTQIQSYHTA 121

  Fly   986 PITGVAAGANNTLIISSSED---------ASIAITDLASGKLRHRITHHRGP--VSGIVVAGAC- 1038
                            :|||         |.|.:.|..|.::.:.::....|  :|.|.|....
  Fly   122 ----------------NSEDVRLFCIGYYAEIMVMDPFSLEVIYVLSSKVKPDWISAIHVLRPMR 170

  Fly  1039 ---DVLISGGLDRTICVWDL----------------DNFTLLNTMQMTSAVLRIDISWNSVFLLA 1084
               ||:::.....|:.||.|                .....||.:.|...      :.|...:|.
  Fly   171 RKDDVVLAITTTGTVKVWTLTGNENKHAEPIYENESKEIRCLNAITMNCC------AQNQRTVLL 229

  Fly  1085 LCE---------DNALYVRTLATGKELHTLKGHKSKIRSISIGKD---SQRCVVGCDDTRALIYD 1137
            :|.         |..:....:|..:|...             |.|   |.|.::..|:.:..:|.
  Fly   230 VCTKYWQIYDAGDFTVLCSVIAPARERWQ-------------GGDFITSDRVMLWTDEGKGYLYK 281

  Fly  1138 M----------------------------HAGKLVRSLPPNPGPVTAVHAMDNDDFLVTVGGNKI 1174
            :                            |||..|.|.||....:.......|     .:.|:..
  Fly   282 LPANCIPDNKEFHSKSVVRDAPYLYYVLQHAGDKVLSCPPAMKLLQGAGGQHN-----LLRGDSE 341

  Fly  1175 TFYSFRN------EELYVNPYSRHPRRKRSLKRHAQAQRSPSTTL---PPITCFD-LSRDS---- 1225
            .:.|..|      :.:.:....:.|  .|.||.|.......:.::   ||:...| |||.:
  Fly   342 GYISVWNVPEVPLDNISILQAKQMP--PRPLKPHVCTSLVEAWSIMDPPPVGILDQLSRITESPV 404

  Fly  1226 ---------QQMAIASGR-----------HVHLMRI---------NTPEYQCTLEGHTAGVSCLK 1261
                     ||..:..||           ...:|::         :.|.:| .|.||...|:||
  Fly   405 KLTSSIYLPQQSRLVIGREDGSIVIVPATQTVMMQLLVGIKQNFSDWPSHQ-ILYGHRGRVNCL- 467

  Fly  1262 FAPN-------GEFLATGSEDRLVHIWNLALGEICNSFKGHTAPVVKVVV--------LMDSLRV 1311
            ..|:       ...|.:|..|..|.:|:|..|.:.:.|..|...:.:::|        ::..:..
  Fly   468 LCPSMIHSRYEKSHLLSGGIDFAVCLWDLYSGSLLHRFCVHAGEITQLLVPPESCSPRILKCICS 532

  Fly  1312 ISTDRDSMLL-------VWMAHSGNLLQTIQGPYKSLSVTNNMRFAVSTNGDNTLKIWSLTQEDE 1369
            :::|....|:       |.:| |.:|...:...::.|.     .|.:....|.::.:|.:
  Fly   533 VASDHSVTLVSLQERKCVTLA-SRHLFPVVTIKWRPLD-----DFLIVGCSDGSVYVWQM----- 586

  Fly  1370 KYSVSHSDEI-----------TCFEISAD----------------------SVHIISG--SRDMS 1399
              ...|.|.:           .|.|.:.|                      :||...|  ||:|:
  Fly   587 --ETGHLDRVLHGMLAEEVLSACDEQAEDGGSGGGGGSNGASASEMGMANPAVHFFRGLKSRNMN 649

  Fly  1400 LKVWQATGGKLSQV--LVGHSDAVTCVAVSVTNKTQVLSGSK------DMNLILWDL-------- 1448
             .:..||...::|:  |.||:.......:...:...|:.|.:      :.:::.:|:
  Fly   650 -AIRHATQRGITQLQQLQGHNQGNFDFLMKHRSNPLVIQGLRTNPKDAESHILFFDIEGLIFELH 713

  Fly  1449 ------LTGEEVHTLAGHL-GPVIGVKVSADGST---------------------------AVSG 1479
                  :|...:.:|..|| .|..|..:..|.|.                           .|..
  Fly   714 SEEYAQMTPATLESLGVHLQNPKDGKSMHLDASKKIGDFFNKVKNKAVDVEKILKDKDKHGLVQK 778

  Fly  1480 SDDKTLIVWETKRGLALTSLQMHV-----------------PFTHFDISLEVSRVLVQLVDSYNL 1527
            ..:||.|| |.|....:.|||..|                 ..||.   :||:::|:.|:.|:.|
  Fly   779 FKEKTEIV-EKKVQAKVESLQKAVEPHEEQQDLKSKIASKMEVTHV---MEVAQLLLSLLHSWGL 839

  Fly  1528 ----------------PVICLHNTPAQY----------VKLPTYSGPSKDVEDLRPQG---PKRQ 1563
                            |::     |..|          :.|||:..     ....|.|   |...
  Fly   840 DPHLDKMCETRLGLLRPIV-----PISYGVLSKAGYMSLLLPTWQN-----NYAIPPGIQLPSSS 894

  Fly  1564 MKRLLKKEVS-LDTYT--------WQKK----YGHLTSSVMMAQVDERLKRRFSVSASM------ 1609
            .||.|.:|:. |:..|        |:..    ..|:.:.|.|:..      ..|:||:.
  Fly   895 KKRPLPEELQRLEHLTAVFTSRLHWELSTTLTTNHILALVAMSNT------LLSMSAASFLPDSE 953

  Fly  1610 --EEISKIAETKTGASQANLGPEQAALAQSQHFDQLEALWNKRSPPRRRHNAGLSRQTSLVEDRL 1672
              :::.::|: :|.::.:|  .|:.....:.|..|::..|:..:          :....|:.|::
  Fly   954 KHKKLQRLAQ-RTDSTLSN--EEEREELMAHHISQIKHAWSLLA----------THHCFLLPDKI 1005

  Fly  1673 ESSDDDEYQDERAGMLSASYDNIHH---------------LARL--PGLRSLHDAWKTNSLRVPS 1720
            |:.:..:::..:..|:...:.  ||               |.|:  .|.:.|.::|
  Fly  1006 EALEPKKFKRPQVEMMVKRWQ--HHCIEIREAAQQILLGELTRMGKKGRKQLVESW--------- 1059

  Fly  1721 RSARTKFYVSTPPPQNSQNSSSL 1743
             :.....|..|.|...:|...:|
  Fly  1060 -AQYLPLYTHTEPIVGAQQQLAL 1081

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30116	NP_725799.1	AAA_16	359..505	CDD:289934
		WD40 repeat	901..937	CDD:293791	6/39 (15%)
		WD40	933..1282	CDD:238121	90/485 (19%)
		WD40 repeat	942..982	CDD:293791	12/51 (24%)
		WD40 repeat	988..1024	CDD:293791	7/44 (16%)
		WD40	1022..1484	CDD:225201	110/673 (16%)
		WD40 repeat	1029..1064	CDD:293791	11/54 (20%)
		WD40 repeat	1071..1106	CDD:293791	6/43 (14%)
		WD40 repeat	1112..1147	CDD:293791	10/65 (15%)
		WD40 repeat	1216..1252	CDD:293791	12/69 (17%)
		WD40	1248..1502	CDD:238121	65/360 (18%)
		WD40 repeat	1258..1294	CDD:293791	11/42 (26%)
		WD40 repeat	1299..1335	CDD:293791	7/50 (14%)
		WD40 repeat	1340..1374	CDD:293791	4/33 (12%)
		WD40 repeat	1379..1415	CDD:293791	12/72 (17%)
		WD40 repeat	1421..1458	CDD:293791	4/56 (7%)
		WD40 repeat	1464..1488	CDD:293791	7/50 (14%)
Rbcn-3B	NP_001284797.1	WD40	<11..>204	CDD:225201	48/222 (22%)
		WD40 repeat	20..63	CDD:293791	8/42 (19%)
		WD40	<22..202	CDD:295369	42/197 (21%)
		WD40 repeat	68..107	CDD:293791	9/40 (23%)
		WD40 repeat	118..152	CDD:293791	10/49 (20%)
		WD40 repeat	160..204	CDD:293791	9/43 (21%)
		WD40 repeat	212..251	CDD:293791	7/44 (16%)
		WD40 repeat	406..459	CDD:293791	8/53 (15%)
		WD40	<449..>607	CDD:225201	31/172 (18%)
		WD40	453..>597	CDD:295369	30/158 (19%)
		WD40 repeat	513..555	CDD:293791	5/42 (12%)
		WD40 repeat	560..596	CDD:293791	6/47 (13%)
		WD40	<1395..>1469	CDD:225201
		WD40	<1399..1495	CDD:295369
		WD40 repeat	1439..1466	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4155
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900